Falcons vs. 49ers Odds & Betting Predictions - October 20, 2025
Falcons at 49ers
12:20 am • NBC/PeacockFalcons at 49ers Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline  | ||||
|---|---|---|---|---|
Falcons 3-5 | +6.5  | +0.5-115  | o46.5-110  | -115  | 
49ers 6-3  | u47.5  | -0.5-105  | u46.5-110  | -105  | 

Levi's StadiumSanta Clara
Falcons vs. 49ers Expert Picks
Roger Goodell
Last 30d: 45-43-1 (+4.1u)
SF -105 (Live)
1.9u
(Exclusive Oddible play transfer)
Player Prop Savant
Last 30d: 34-35-0 (-3.0u)
Over 34.5 (Live)-136
0.68u
Brandon Kravitz
Last 30d: 78-88-2 (-1.6u)
ATL +6.5 (Live)-105
1.05u
ATL +210 (Live)
0.6u
FTN Fantasy
Last 30d: 52-49-0 (+4.9u)
SF -2.5 (Live)-115
1.74u
Top Shelf Action 🥃
Last 30d: 210-190-2 (-2.4u)
M.Penix u0.5 Int+110
1.65u
M.Penix u1.5 Pass TDs-135
1.26u
Cam Is Money
Last 30d: 80-84-1 (-0.8u)
M.Jones o0.5 Int-130
0.77u
Top Shelf Action 🥃
Last 30d: 210-190-2 (-2.4u)
K.Bourne o4.5 Recs+125
0.7u
Mjaybrod
Last 30d: 104-109-0 (+4.0u)
SF -113
0.88u
Top Shelf Action 🥃
Last 30d: 210-190-2 (-2.4u)
B.Robinson u75.5 Rush Yds+115
1.27u
The Propfessor
Last 30d: 44-50-0 (+4.6u)
C.McCaffrey o64.5 Rush Yds-112
0.89u
Gilles Gallant
Last 30d: 31-91-1 (-10.7u)
J.Bates o6.5 Tackles + Ast+120
0.6u
#Tailing @The_Oddsmaker 
Sean Koerner
Last 30d: 59-38-0 (+12.1u)
J.Bates o6.5 Tackles + Ast+109
0.55u
Bates has cleared this in 3 of 5 games and I think the market is slow to catch up to the fact that he’s playing in the box at a 15% higher rate this season. That’s key against San Francisco, who are one of the best matchups for strong safeties, since Bates should mix in on everything.. CMC runs/rec, Kittle receptions, and even quick-game stuff over the middle.
I’m projecting Atlanta to face 7.5 more completions than usual which helps Bates specifically. They’ve faced the fewest plays per game of any defense so far, while San Francisco leads the league in plays per game..a huge boost in opportunity by itself.
Even better, 49ers scorekeepers hand out assists at the 3rd-highest rate in the league.
I’m projecting around a 58% hit rate, but considering the plus odds and so many underlying factors in its favor, this is my favorite prop for SNF.
Markus Markets
Last 30d: 52-39-2 (+18.7u)
M.Jones u249.5 Pass Yds-115
0.87u
💰🦡 Jake
Last 30d: 111-115-10 (+12.8u)
D.Mooney First Touchdown Scorer Yes+1700
0.1u
Top Shelf Action 🥃
Last 30d: 210-190-2 (-2.4u)
D.London o68.5 Rec Yds-110
1.4u
Allan Lem
Last 30d: 161-113-1 (+13.3u)
SF -110
0.5u
I get it’s Mac Jones with a banged up receiving group but I just can’t pass up these odds for the 49ers at home.
YBK Picks.com
Last 30d: 65-43-2 (+40.6u)
ATL +1-105
2u
Collin Wilson
Last 30d: 98-77-1 (+17.5u)
SF -110
1u
The Degenerates
Last 30d: 63-65-1 (-7.4u)
B.Robinson o120.5 Rush + Rec Yds-115
1.15u
Over 46.5-118
1.18u

Chris Raybon
Last 30d: 20-32-1 (-10.8u)
SF -110
0.91u
Top Shelf Action 🥃
Last 30d: 210-190-2 (-2.4u)
M.Jones o23.5 Pass Comp+151
1.7u
Brian Bitler 
Last 30d: 82-83-2 (-12.5u)
ATL +1.5-105
3u
Babs .
Last 30d: 106-123-3 (-13.6u)
K.Pitts o35.5 Rec Yds-114
0.88u
Kenny Ducey
Last 30d: 20-21-0 (-3.4u)
ATL +1.5-111
1.11u
Matt DiLeo
Last 30d: 43-44-0 (-7.4u)
Both Teams To Make 33+ Yard FG   -125
0.8u
Picks Office
Last 30d: 147-126-4 (+12.0u)
ATL +2.5-110
1u
X: PicksOffice
Anders
Last 30d: 10-18-0 (-12.3u)
ATL +2.5-115
1.15u
Analysis on Tiktok
Derek Carty
Last 30d: 25-22-0 (+7.5u)
D.Robinson u19.5 Rec Yds-110
1u
There is a value opportunity on Demarcus Robinson's receptions prop. THE BLITZ is projecting him to record 1.09 receptions, while sportsbooks imply 1.97.  The model believes there is a 70% chance he records fewer than 1.5 receptions, so there is some value on the under at +105. (This play is good down to at least -158.)    Love THE BLITZ? Get all of Carty’s sports betting projections at EV Analytics: https://evanalytics.com/products/nfl-premium-subscription?ref=zdlkmgz
Brandon Anderson
Last 30d: 57-104-0 (+10.4u)
ATL +2.5-115
1u
We just watched the Falcons win a big one Monday night against the Bills. That was an impressive performance but does mean this isn't a great spot for Atlanta, playing on short rest after such a big win for the franchise.
Still, these just look like two teams headed in opposite directions.
Atlanta had that weird shutout loss to Carolina but has otherwise been pretty impressive on the season, especially defensively.
As for the 49ers, the record still looks good but the injury report is long and depressing.
Both Brock Purdy and Mac Jones entered the week banged up, and so did receivers Jauan Jennings and Ricky Pearsall. Purdy and Pearsall have been ruled out. Jones and Jennings will play but at less than 100%, though it does look like George Kittle returns.
Even so, this team is missing its franchise QB and arguably its top two receivers — don't forget Brandon Aiyuk is still out too!
But the defense is in even worse shape. It looks like both CB Renardo Green and ED Yatur Gross-Matos could miss. You may not know those names but they're probably San Francisco's top option at each spot — in part because of the cascading effect of injuries to San Francisco's two defensive superstars, Nick Bosa and Fred Warner, both out for the season.
San Francisco is a fringe bottom 10 defense by DVOA on the season and almost certainly even worse than those metrics would indicate, since Bosa and Warner played for much of that.
The Niners are getting zero pressure on opposing quarterbacks, ranking 31st in pressure rate on the season, and Atlanta ranks lowest in pressure rate allowed. Michael Penix should have plenty of time to attack this defense.
San Francisco also plays a ton of light-box defense, at 98% of its snaps by far the most in the league, typically relying on Fred Warner to clean up the back end when necessary. Atlanta ranks fourth in EPA per play against light boxes, and Bijan Robinson and Tyler Allgeier could bust some more big plays if they face light fronts all game.
On the other side of the ball, Atlanta is somewhat beatable against the run but the 49ers have not run well all season. Christian McCaffrey is seeing volume, but the 49ers rank bottom five rushing by DVOA.
San Francisco will need to pass, and the Falcons lead the league in pass defense DVOA. Atlanta's small speedy pass rushers have really gotten after the opposing quarterback. The 49ers have done a great job at limiting pressure rate, but Atlanta ranks top five in pressures and the 49ers are 27th in EPA per play when under pressure.
That's an area where Purdy's loss is even more significant. Purdy can move and create but Jones is much more of a statue, even more so while he plays through his own injuries.
I waited on this one, hoping we might hit Atlanta +3 if the right injury news came out, but it's not going to get there with Purdy out. I'm happy to grab Atlanta +2.5 at ESPN Bet and see if the Falcons can pull off a second straight primetime upset.
Gilles Gallant
Last 30d: 31-91-1 (-10.7u)
D.London Anytime TD Scorer Yes+170
0.6u
Bet Labs
Last 30d: 22-24-0 (+1.1u)
SF -125
1u
Boomer Betz
Last 30d: 203-181-4 (+35.0u)
C.McCaffrey u46.5 Rec Yds-110
1u
Action Pod NFL Picks
Last 30d: 76-134-0 (+0.2u)
ATL +2.5-105
1u
@wheatonbrando https://myaction.app/bIlPMohsyXb
TAN Pod Touchdown Show
Last 30d: 28-90-2 (-1.6u)
G.Kittle Anytime TD Scorer Yes+170
0.33u
 @The_Oddsmaker https://myaction.app/MsfxZEmqyXb
D.London Anytime TD Scorer Yes+155
0.33u
 @GDAWG5000 https://myaction.app/MsfxZEmqyXb
K.Juszczyk Anytime TD Scorer Yes+900
0.33u
 @ChrisRaybon https://myaction.app/MsfxZEmqyXb
Derek Carty
Last 30d: 25-22-0 (+7.5u)
M.Jones o5.5 Rush Yds-108
1u
THE BLITZ is forecasting 13.76 rushing yards for Mac Jones.  The oddsmakers' implied projection is 9.06 rushing yards, so I believe there is some value here. If you take the over, you’d be projected to win 69% of the time resulting in a 33% ROI with expected value of $35.98 (based on a $100 wager). (This play is good down to at least -151.)
Love THE BLITZ? Get all of Carty’s sports betting projections at EV Analytics: https://evanalytics.com/products/nfl-premium-subscription?ref=zdlkmgz
David Payne
Last 30d: 11-10-1 (+2.2u)
ATL +100
1.5u
#SodaBet
Gilles Gallant
Last 30d: 31-91-1 (-10.7u)
G.Kittle Anytime TD Scorer Yes+220
0.5u
Sandy Plashkes
Last 30d: 105-115-1 (-8.9u)
SF -130
1u
💰🦡 Jake
Last 30d: 111-115-10 (+12.8u)
ATL +2-109
1.09u
Mjaybrod
Last 30d: 104-109-0 (+4.0u)
SF -130
0.77u
Injured Reserved ML
Boomer Betz
Last 30d: 203-181-4 (+35.0u)
SF -124
0.81u
Falcons vs. 49ers Previews & Analysis
Falcons vs. 49ers Props
Prop Projections
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Prop Odds Comparison
Line Movement Tracker
Falcons vs. 49ers Public Betting Percentages
Betting Trends
- 49ers are 2-3 in their last 5 games.
 - 49ers are 2-3 in their last 5 games against the spread
 - 49ers are 4-2 in their road games against the spread
 - The totals have gone OVER in 3 of 49ers' last 5 games
 - The totals have gone OVER in 1 of 49ers' 3 last games at home
 
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Falcons vs. 49ers Injury Updates

Falcons Injuries
- Jamal AgnewWR
Agnew is out with groin
Out
 - DeMarcco HellamsS
Hellams is out with hamstring
Out
 - Jack NelsonOL
Nelson is out with calf
Out
 

49ers Injuries
- Brandon AiyukWR
Aiyuk is out with knee
Out
 - Brock PurdyQB
Purdy is out with toe
Out
 - Ricky PearsallWR
Pearsall is out with knee
Out
 - Jacob CowingWR
Cowing is out with hamstring
Out
 - Jordan JamesRB
James is doubtful with finger
Doubtful
 
Team Stats
Falcons vs. 49ers Odds Comparison
Could not load odds
Falcons at 49ers Team Totals
MatchupOverUnder  | ||
|---|---|---|
Falcons 3-5 | o23-118  | u23-104  | 
49ers 6-3  | o23.5-104  | u23.5-119  | 




