 Diamondbacks | Kole Calhoun | OF | Out indefinitely | Strained left hamstring | Kole Calhoun placed on 10-day IL. | Apr 28 |
| Diamondbacks | Madison Bumgarner | P | Out indefinitely | Left shoulder inflammation | Madison Bumgarner placed on 10-day IL. | Jun 3 |
| Diamondbacks | Luke Weaver | P | Out indefinitely | Right shoulder discomfort | Luke Weaver to be placed on 10-day IL. | May 18 |
| Diamondbacks | Seth Frankoff | P | Out indefinitely | Sore right forearm | Seth Frankoff placed on 10-day IL. | Jun 4 |
| Diamondbacks | Taylor Widener | P | Out indefinitely | Strained right groin | Taylor Widener to be placed on 10-day IL. | May 25 |
 Braves | Travis d'Arnaud | C | Out indefinitely | Left thumb surgery | Travis d'Arnaud to undergo thumb surgery. | May 2 |
| Braves | Marcell Ozuna | OF | Out indefinitely | Dislocated left ring, middle finger | Ozuna is injured with finger | May 30 |
| Braves | Alex Jackson | C | Out indefinitely | Strained left hamstring | Alex Jackson placed on 10-day IL. | May 2 |
| Braves | Mike Soroka | P | Out indefinitely | Torn right Achilles tendon | Soroka is injured with achilles | May 28 |
| Braves | Touki Toussaint | P | Out indefinitely | Strained right shoulder | Toussaint is injured with shoulder | Mar 30 |
| Braves | Tucker Davidson | P | Out indefinitely | Strained left forearm | Tucker Davidson to be placed on 10-day IL. | Jun 16 |
| Braves | Huascar Ynoa | P | Out indefinitely | Broken hand | Huascar Ynoa out a couple months with broken hand from punching dugout bench. | May 17 |
 Orioles | Chris Davis | IF | Out for season | Left hip surgery | Chris Davis underwent season-ending hip surgery. | May 19 |
| Orioles | John Means | P | Out indefinitely | Strained left shoulder | John Means placed on 10-day IL. | Jun 6 |
 Red Sox | Christian Vázquez | C | Questionable | Stomach illness | Vazquez is questionable with illness | Jun 17 |
 Cubs | Austin Romine | C | Out indefinitely | Sprained left wrist | Austin Romine placed on 10-day IL. | Apr 26 |
| Cubs | Matt Duffy | IF | Out indefinitely | Strained lower back | Matt Duffy placed on 10-day IL. | May 25 |
| Cubs | Trevor Williams | P | Out indefinitely | Appendicitis | Trevor Williams placed on 10-day IL. | May 31 |
| Cubs | P.J. Higgins | C | Out indefinitely | Strained right forearm | P.J. Higgins (forearm) placed on 10-day IL. | Jun 11 |
| Cubs | David Bote | IF | Out indefinitely | Dislocated left shoulder | David Bote placed on 10-day IL. | May 30 |
| Cubs | Adbert Alzolay | P | Out indefinitely | Right middle finger blister | Adbert Alzolay placed on 10-day IL. | Jun 8 |
| Cubs | Nico Hoerner | IF | Out indefinitely | Strained left hamstring | Nico Hoerner placed on 10-day IL. | May 26 |
 White Sox | Adam Eaton | OF | Out indefinitely | Strained right hamstring | Adam Eaton placed on 10-day IL. | Jun 17 |
| White Sox | Billy Hamilton | OF | Out indefinitely | Strained oblique | Billy Hamilton placed on 10-day IL. | Jun 6 |
| White Sox | Eloy Jiménez | OF | Out indefinitely | Ruptured left pectoral tendon | Jimenez is injured with chest | Mar 30 |
| White Sox | Luis Robert | OF | Out indefinitely | Strained hip flexor | Luis Robert (hip) to miss 12-16 weeks. | May 3 |
| White Sox | Nick Madrigal | IF | Out for season | Right hamstring surgery | Nick Madrigal underwent season-ending hamstring surgery. | Jun 15 |
 Reds | Mike Moustakas | IF | Out indefinitely | Right heel contusion | Mike Moustakas placed on 10-day IL. | May 20 |
| Reds | Sonny Gray | P | Out indefinitely | Strained right groin | Sonny Gray placed on 10-day IL. | Jun 9 |
| Reds | Michael Lorenzen | P | Out indefinitely | Strained shoulder | Lorenzen is injured with shoulder | Mar 30 |
| Reds | Nick Senzel | OF | Out indefinitely | Left knee surgery | Nick Senzel to undergo knee surgery; expected to miss 4-6 weeks. | May 26 |
| Reds | Jeff Hoffman | P | Out indefinitely | Right shoulder | Jeff Hoffman placed on 10-day IL. | May 27 |
| Reds | Max Schrock | IF | Out indefinitely | Strained left calf | Max Schrock placed on 10-day IL. | Jun 1 |
| Reds | Alex Blandino | IF | Out indefinitely | Broken right hand | Alex Blandino placed on 10-day IL. | Jun 5 |
 Indians | Roberto Pérez | C | Out indefinitely | Fractured finger | Roberto Perez placed on 10-day IL. | May 5 |
| Indians | Austin Hedges | C | Out indefinitely | Concussion | Austin Hedges placed on 7-day concussion IL. | Jun 17 |
| Indians | Shane Bieber | P | Out indefinitely | Strained right shoulder | Shane Bieber to be placed on IL. | Jun 14 |
| Indians | Jordan Luplow | OF | Out indefinitely | Ankle | Jordan Luplow placed on 10-day IL. | May 28 |
| Indians | Franmil Reyes | DH | Out indefinitely | Strained left abdominal | Franmil Reyes to be placed on 10-day IL. | May 23 |
| Indians | Zach Plesac | P | Out indefinitely | Fractured right thumb | Zach Plesac diagnosed with fractured thumb. | May 25 |
 Rockies | Ian Desmond | OF | Out for season | Personal | Desmond is out for season with personal | Mar 30 |
| Rockies | Chris Owings | IF | Out indefinitely | Left thumb surgery | Owings is injured with thumb | Apr 18 |
| Rockies | Matt Adams | IF | Out indefinitely | Strained right elbow | Matt Adams placed on 10-day IL. | Jun 9 |
| Rockies | Jon Gray | P | Out indefinitely | Right flexor strain | Jon Gray placed on 10-day IL. | Jun 5 |
| Rockies | Peter Lambert | P | Out indefinitely | Tommy John surgery | Lambert is injured with elbow | Mar 30 |
 Tigers | Matthew Boyd | P | Out indefinitely | Left arm discomfort | Matthew Boyd placed on 10-day IL. | Jun 15 |
| Tigers | Julio Teheran | P | Out indefinitely | Strained right shoulder | Julio Teheran placed on 10-day IL. | Apr 10 |
| Tigers | Wilson Ramos | C | Out indefinitely | Strained lumbar spine | Wilson Ramos placed on 10-day IL. | May 24 |
| Tigers | Derek Hill | OF | Out indefinitely | Sprained right shoulder | Derek Hill placed on 10-day IL. | Jun 10 |
| Tigers | Spencer Turnbull | P | Out indefinitely | Strained right forearm | Spencer Turnbull placed on 10-day IL. | Jun 5 |
| Tigers | Grayson Greiner | C | Out indefinitely | Strained left hamstring | Grayson Greiner placed on 10-day IL. | May 12 |
| Tigers | Victor Reyes | OF | Out indefinitely | Strained left intercostal | Victor Reyes placed on 10-day IL. | Jun 3 |
 Astros | Justin Verlander | P | Out indefinitely | Tommy John surgery | Verlander is injured with arm | Mar 30 |
| Astros | Aledmys Díaz | IF | Out indefinitely | Fractured left hand | Aledmys Diaz placed on 10-day IL. | Jun 8 |
| Astros | Alex Bregman | IF | Out indefinitely | Strained left quad | Alex Bregman placed on 10-day IL. | Jun 17 |
| Astros | Kyle Tucker | OF | Out indefinitely | Health & Safety protocols | Kyle Tucker placed on injured list. | Jun 16 |
 Royals | Danny Duffy | P | Out indefinitely | Strained left forearm flexor | Danny Duffy placed on 10-day IL. | May 17 |
| Royals | Andrew Benintendi | OF | Out indefinitely | Fractured right rib | Andrew Benintendi placed on 10-day IL. | Jun 14 |
 Angels | José Quintana | P | Out indefinitely | Left shoulder inflammation | Jose Quintana placed on 10-day IL. | May 31 |
| Angels | Mike Trout | OF | Out indefinitely | Strained right calf | Mike Trout placed on 10-day IL. | May 18 |
| Angels | Dexter Fowler | OF | Out indefinitely | Torn ACL | Dexter Fowler diagnosed with torn ACL. | Apr 11 |
| Angels | Anthony Rendon | IF | Questionable | Triceps | Rendon is questionable with triceps | Jun 16 |
| Angels | Franklin Barreto | IF | Out for season | Tommy John surgery | Franklin Barreto to undergo Tommy John surgery. | May 11 |
 Dodgers | Max Muncy | IF | Out indefinitely | Strained right oblique | Max Muncy placed on 10-day IL. | Jun 13 |
| Dodgers | Corey Seager | IF | Out indefinitely | Fractured right hand | Corey Seager diagnosed with fractured hand. | May 16 |
| Dodgers | Cody Bellinger | OF | Out indefinitely | Tight left hamstring | Cody Bellinger placed on 10-day IL. | Jun 16 |
| Dodgers | Edwin Ríos | IF | Out for season | Torn labrum | Edwin Rios to undergo season ending surgery. | May 12 |
| Dodgers | Dustin May | P | Out for season | Tommy John surgery | Dustin May to undergo Tommy John surgery. | May 3 |
| Dodgers | Yoshi Tsutsugo | OF | Out indefinitely | Strained right calf | Yoshitomo Tsutsugo placed on 10-day IL. | Jun 9 |
 Marlins | Corey Dickerson | OF | Out indefinitely | Left foot contusion | Dickerson is injured with foot | Jun 15 |
| Marlins | Miguel Rojas | IF | Out indefinitely | Dislocated left index finger | Miguel Rojas to be placed on IL. | May 27 |
| Marlins | Brian Anderson | IF | Out indefinitely | Left shoulder subluxation | Brian Anderson placed on 10-day IL. | May 25 |
| Marlins | Nick Neidert | P | Out indefinitely | Right biceps inflammation | Nick Neidert placed on 10-day IL. | May 27 |
| Marlins | Garrett Cooper | OF | Out indefinitely | Strained lumbar | Garrett Cooper to be placed on 10-day IL. | Jun 9 |
| Marlins | José Devers | IF | Out indefinitely | Right shoulder discomfort | Jose Devers placed on IL. | Jun 14 |
| Marlins | Elieser Hernandez | P | Out indefinitely | Strained quad | Elieser Hernandez (quad) to be placed on 10-day IL. | Jun 4 |
 Brewers | Travis Shaw | IF | Out indefinitely | Dislocated left shoulder | Shaw is injured with shoulder | Jun 13 |
| Brewers | Lorenzo Cain | OF | Out indefinitely | Strained right hamstring | Lorenzo Cain to be placed on 10-day IL. | Jun 1 |
| Brewers | Kolten Wong | IF | Out indefinitely | Strained left oblique | Kolten Wong (oblique) placed on 10-day IL. | Jun 4 |
| Brewers | Tyrone Taylor | OF | Out indefinitely | Strained right shoulder | Tyrone Taylor placed on 10-day IL. | Jun 12 |
 Twins | Josh Donaldson | IF | Questionable | Tight right calf | Donaldson is questionable with calf | Jun 17 |
| Twins | Rob Refsnyder | OF | Out indefinitely | Strained left hamstring | Rob Refsnyder placed on 10-day IL. | Jun 14 |
| Twins | Michael Pineda | P | Out indefinitely | Right elbow inflammation | Michael Pineda placed on 10-day IL. | Jun 14 |
| Twins | Byron Buxton | OF | Questionable | Strained hip | Buxton is questionable with hip | Jun 17 |
| Twins | Max Kepler | OF | Out indefinitely | Strained left hamstring | Max Kepler placed on 10-day IL. | May 30 |
| Twins | Andrelton Simmons | IF | Questionable | Tight left ankle | Simmons is questionable with ankle | Jun 17 |
| Twins | Jake Cave | OF | Out indefinitely | Lower back stress reaction | Jake Cave placed on 60-day IL. | May 15 |
| Twins | Keon Broxton | OF | Out | One-game suspension | Broxton is out with suspension | Sep 2 |
| Twins | Mitch Garver | C | Out indefinitely | Groin surgery | Mitch Garver underwent groin surgery. | Jun 2 |
| Twins | Kyle Garlick | OF | Out indefinitely | Sports hernia | Kyle Garlick to be placed on IL. | Jun 9 |
 Mets | Carlos Carrasco | P | Out indefinitely | Strained hamstring | Carrasco is injured with hamstring | Mar 30 |
| Mets | Tommy Hunter | P | Out indefinitely | Lower back pain | Tommy Hunter placed on 10-day IL. | May 21 |
| Mets | Michael Conforto | OF | Out indefinitely | Tight right hamstring | Michael Conforto likely to be placed on 10-day IL. | May 17 |
| Mets | Brandon Nimmo | OF | Out indefinitely | Left index finger bone bruise | Nimmo is injured with finger | May 14 |
| Mets | Noah Syndergaard | P | Out indefinitely | Tommy John surgery | Syndergaard is injured with elbow | Mar 30 |
| Mets | Albert Almora Jr. | OF | Out indefinitely | Left shoulder contusion | Albert Almora to be placed on 10-day IL. | May 12 |
| Mets | J.D. Davis | IF | Out indefinitely | Sprained left hand | Davis is injured with hand | May 15 |
| Mets | Jordan Yamamoto | P | Out indefinitely | Sore right shoulder | Jordan Yamamoto placed on 10-day IL. | May 25 |
| Mets | Johneshwy Fargas | OF | Out indefinitely | Sprained AC joint | Fargas is injured with shoulder | May 26 |
| Mets | Jeff McNeil | IF | Out indefinitely | Tight left hamstring | Jeff McNeil to be placed on 10-day IL. | May 17 |
 Yankees | Aaron Hicks | OF | Out for season | Left wrist surgery | Aaron Hicks expected to miss the rest of the season. | May 27 |
| Yankees | Luis Severino | P | Out indefinitely | Tommy John surgery | Severino is injured with elbow | Mar 30 |
| Yankees | Corey Kluber | P | Out indefinitely | Strained subcap | Corey Kluber expected to miss more than 4 weeks. | May 26 |
| Yankees | Luke Voit | IF | Out indefinitely | Strained right oblique | Luke Voit placed on 10-day IL. | May 26 |
 Athletics | Mike Fiers | P | Out indefinitely | Sprained right elbow | Mike Fiers placed on 10-day IL. | May 8 |
| Athletics | Chad Pinder | OF | Questionable | Head | Pinder is questionable with head | Jun 17 |
 Phillies | Didi Gregorius | IF | Out indefinitely | Right elbow impingement | Didi Gregorius (elbow) placed on 10-day IL. | May 18 |
| Phillies | Jean Segura | IF | Out indefinitely | Strained left groin | Jean Segura placed on 10-day IL. | Jun 17 |
| Phillies | Roman Quinn | OF | Out for season | Ruptured left Achilles | Roman Quinn to undergo season-ending Achilles surgery. | May 31 |
| Phillies | Bryce Harper | OF | Questionable | Tight lower back | Harper is questionable with back | Jun 16 |
 Pirates | Trevor Cahill | P | Out indefinitely | Strained left calf | Trevor Cahill placed on 10-day IL. | Jun 12 |
| Pirates | Colin Moran | IF | Questionable | Tight lower back | Moran is questionable with back | Jun 17 |
| Pirates | Steven Brault | P | Out indefinitely | Strained lat | Brault is injured with back | Mar 30 |
 Padres | Mike Clevinger | P | Out indefinitely | Tommy John surgery | Clevinger is injured with arm | Mar 30 |
| Padres | Austin Nola | C | Out indefinitely | Sprained knee | Austin Nola to be placed on 10-day IL. | May 27 |
| Padres | Adrian Morejon | P | Out indefinitely | Tommy John surgery | Adrian Morejon to undergo Tommy John surgery. | Apr 20 |
 Giants | Aaron Sanchez | P | Out indefinitely | Tight right biceps | Aaron Sanchez placed on 10-day IL. | May 8 |
| Giants | Evan Longoria | IF | Out indefinitely | Sprained left shoulder | Evan Longoria to be placed on 10-day IL. | Jun 6 |
| Giants | Tommy La Stella | IF | Out indefinitely | Strained left hamstring | Tommy La Stella placed on 10-day IL. | May 4 |
| Giants | Alex Dickerson | OF | Out indefinitely | Strained upper back | Alex Dickerson placed on 10-day IL. | Jun 9 |
| Giants | Darin Ruf | IF | Out indefinitely | Right hamstring | Darin Ruf placed on 10-day IL. | May 27 |
| Giants | Tyler Beede | P | Out indefinitely | Tommy John surgery | Beede is injured with elbow | Mar 30 |
| Giants | Logan Webb | P | Out indefinitely | Strained right shoulder | Logan Webb placed on 10-day IL. | Jun 3 |
 Mariners | James Paxton | P | Out indefinitely | Tommy John surgery | James Paxton to undergo Tommy John surgery. | Apr 13 |
| Mariners | Kyle Lewis | OF | Out indefinitely | Torn right meniscus | Kyle Lewis diagnosed with torn meniscus. | Jun 1 |
| Mariners | Evan White | IF | Out indefinitely | Hip flexor | Evan White placed on 10-day IL. | May 14 |
| Mariners | Ljay Newsome | P | Out indefinitely | Right elbow inflammation | Ljay Newsome placed on 10-day IL. | May 9 |
| Mariners | Sam Haggerty | OF | Out indefinitely | Right shoulder inflammation | Sam Haggerty placed on 10-day IL. | May 25 |
| Mariners | Nick Margevicius | P | Out indefinitely | Left shoulder inflammation | Nick Margevicius placed on 10-day IL. | Apr 26 |
 Cardinals | Max Moroff | IF | Out for season | Shoulder surgery | Max Moroff to undergo season-ending surgery. | Jun 6 |
| Cardinals | Dakota Hudson | P | Out indefinitely | Tommy John surgery | Hudson is injured with elbow | Mar 30 |
| Cardinals | Edmundo Sosa | IF | Out | Right hand contusion | Sosa is out with hand | Jun 17 |
| Cardinals | Jack Flaherty | P | Out indefinitely | Strained left oblique | Jack Flaherty to be placed on IL. | Jun 2 |
| Cardinals | Harrison Bader | OF | Out indefinitely | Right rib hairline fracture | Harrison Bader placed on 10-day IL. | May 25 |
| Cardinals | Justin Williams | OF | Out indefinitely | Stiff neck | Justin Williams to be placed on IL. | Jun 5 |
| Cardinals | Miles Mikolas | P | Out indefinitely | Tight forearm | Miles Mikolas placed on 10-day IL. | May 23 |
 Rays | Chris Archer | P | Out indefinitely | Tight right forearm | Chris Archer placed on 10-day IL. | Apr 10 |
| Rays | Tyler Glasnow | P | Out indefinitely | Strained flexor, partially torn UCL | Tyler Glasnow diagnosed with partially torn UCL. | Jun 15 |
| Rays | Yonny Chirinos | P | Out indefinitely | Strained right elbow | Chirinos is injured with elbow | Mar 30 |
| Rays | Luis Patiño | P | Out indefinitely | Right middle finger laceration | Luis Patiño placed on 10-day IL. | May 19 |
 Rangers | David Dahl | OF | Out indefinitely | Left rib cage contusion | David Dahl placed on 10-day IL. | May 26 |
| Rangers | Ronald Guzmán | IF | Out for season | Torn right meniscus | Ronald Guzman to miss rest of season. | Apr 23 |
| Rangers | Kohei Arihara | P | Out indefinitely | Right middle finger contusion | Kohei Arihara placed on 10-day IL. | May 9 |
 Blue Jays | George Springer | OF | Out indefinitely | Strained right quad | George Springer placed on 10-day IL. | May 6 |
| Blue Jays | Steven Matz | P | Out | COVID-19 list | Matz is out with covid protocols | Jun 13 |
| Blue Jays | Danny Jansen | C | Out indefinitely | Strained right hamstring | Danny Jansen placed on 10-day IL. | Jun 8 |
| Blue Jays | Jonathan Davis | OF | Out | Paternity | Jonathan Davis placed on paternity list. | Jun 15 |
| Blue Jays | Alejandro Kirk | C | Out indefinitely | Strained left hip flexor | Kirk is injured with hip | May 2 |
 Nationals | Starlin Castro | IF | Questionable | Restricted list | Castro is questionable with personal | Jun 17 |
| Nationals | Max Scherzer | P | Out indefinitely | Groin inflammation | Max Scherzer placed on 10-day IL. | Jun 15 |
| Nationals | Stephen Strasburg | P | Out indefinitely | Strained neck | Stephen Strasburg placed on 10-day IL. | Jun 2 |
| Nationals | Austin Voth | P | Out indefinitely | Fractured nose | Austin Voth placed on 10-day IL. | Jun 8 |