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49ers vs. Saints Odds & Betting Predictions - September 14, 2025

49ers at Saints

5:00 pm • FOX
Stream Live on SiriusXM - Free 3 Month Offer

San Francisco 49ers

1-0
@

New Orleans Saints

0-1

49ers at Saints Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
49ers
1-0
-7
-4.5-110
o42.5-110
-225
Saints
0-1
u44.5
+4.5-110
u42.5-110
+185
location pinSunday 5:00 p.m.
September 14, 2025
Caesars SuperdomeNew Orleans
49ers vs. Saints Expert Picks
Matthew Freedman
Matthew Freedman
Last 30d: 9-5-0 (+1.5u)
C.McCaffrey Anytime TD Scorer Yes-165
1.65u
Projection: 0.84 TDs, -252.3. For more, check out the Fantasy Life player projections.
Cam Is Money
Cam Is Money
Last 30d: 45-69-1 (-17.6u)
NO +6.5-113
1u
FTN Fantasy
FTN Fantasy
Last 30d: 58-94-0 (-39.0u)
SF -6.5-105
1u

49ers vs. Saints Previews & Analysis

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49ers vs. Saints Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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49ers vs. Saints Public Betting Percentages

Away Logo

49ers

Public

Home Logo

Saints

33%

Bets%

67%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Saints are 0-1 in their last 5 games.
  • Saints are 0-1 in their last 5 games against the spread
  • The totals have gone OVER in 0 of Saints' last 1 games
  • The totals have gone OVER in 0 of Saints' 1 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Saints		0-10-1N/AN/A0-1
49ers		1-0N/A1-01-0N/A

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Saints		0-10-1N/AN/A0-1
49ers		0-1N/A0-10-1N/A

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Saints		0-1N/AN/AN/A0-1
49ers		1-0N/AN/A1-0N/A

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 7thARIL 13-20+5.5 LU 44.5ARI +205
Aug 23rdDENL 19-28+2.5 LO 38.5DEN +120
Aug 17thJACW 17-17+2.5 WU 40.5JAC +112
Aug 10th@LACL 13-27+2.5 LO 39LAC +120
Jan 5th@TBL 19-27+14.5 WO 44.5TB +722

Saints vs. 49ers Injury Updates

Saints Injuries

  • Taysom Hill
    TE

    Hill is out with knee

    Out

  • Chase Young
    DE

    Young is out with calf

    Out

  • Trevor Penning
    OL

    Penning is out with toe

    Out

  • Jordan Howden
    DB

    Howden is questionable with oblique

    Questionable

49ers Injuries

  • Demarcus Robinson
    WR

    Robinson is out with suspension

    Out

  • George Kittle
    TE

    Kittle is out with hamstring

    Out

  • Brandon Aiyuk
    WR

    Aiyuk is out with knee

    Out

  • Jauan Jennings
    WR

    Jennings is questionable with shoulder

    Questionable

  • Brock Purdy
    QB

    Purdy is questionable with toe

    Questionable

  • Jacob Cowing
    WR

    Cowing is out with hamstring

    Out

  • Jordan Watkins
    WR

    Watkins is doubtful with ankle

    Doubtful

  • Jordan James
    RB

    James is doubtful with finger

    Doubtful

See more NFL Injuries Right Arrow
Player Stats
  • passing yards
    Spencer Rattler logo
    Spencer Rattler
    214
    pyds
  • passing touchdowns
    player logo
    -
    -
    ptd
  • rushing yards
    Alvin Kamara logo
    Alvin Kamara
    45
    ryds
  • rushing touchdowns
    Alvin Kamara logo
    Alvin Kamara
    1
    rtd
Depth Charts
Right Arrow
Starter2ND3RD4TH
QBSpencer RattlerTyler ShoughJake Haener
RBAlvin KamaraKendre MillerVelus JonesDevin Neal
WRDevaughn VeleCedrick Wilson
TEJuwan JohnsonFoster MoreauTaysom HillTreyton WelchJack StollMoliki Matavao
LTKelvin BanksLandon YoungBarry Wesley
LGTrevor PenningDillon RadunzEaston Kilty
CErik McCoyLuke Fortner
RGCesar RuizTorricelli Simpkins
RTTaliese Fuaga
RDENathan ShepherdJonathan BullardJonah Williams
WLBPete WernerJaylan FordNephi Sewell
MLBDemario DavisDanny StutsmanNephi Sewell
LCBIsaac YiadomQuincy RileyDalys Beanum
SSJustin ReidJordan HowdenTerrell Burgess
FSJulian BlackmonJonas SankerElliott Davison
RCBKool-Aid McKinstryRejzohn Wright
PKai Kroeger
HKai Kroeger
PRRashid ShaheedCedrick WilsonJayden Price
KRRashid ShaheedVelus JonesKendre MillerJayden Price
LSZach Wood
RWRRashid ShaheedBrandin Cooks
LWRChris OlaveMason TiptonKevin Austin
ROLBCarl GrandersonChris Rumph
DTBryan BreseeVernon Broughton
NBAlontae TaylorUgo AmadiJayden Price
NTDavon GodchauxKhristian BoydJohn Ridgeway
LOLBChase YoungCameron Jordan
KBlake GrupeCharlie Smyth
Team Stats

Passing

265
YDS
208
26/35
Comps/Atts
27/46
7.914
YPA
4.652
2/2
TDs/INTs
0/0
1/12
Sacks/Yards
1/6

Rushing

119
Rush Yards
107
36
Attempts
22
3.306
YPC
4.864
0
TDs
1

Turnovers

Fumbles Lost
2
Interceptions
0

Efficiency

2/5 40%
Redzone
1/4 25%
7/14 0%
3rd Down
5/14 0%
2/2 0%
4th Down
1/2 0%

First Downs

24
Total
21
15
Pass
12
7
Rush
5
2
Penalty
4

Misc

/
Penalties/Yards
/
Possession

49ers vs. Saints Odds Comparison

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49ers at Saints Team Totals

MatchupOverUnder
49ers
1-0
N/A
N/A
Saints
0-1
N/A
N/A