49ers vs. Buccaneers Odds & Betting Predictions - October 12, 2025

49ers at Buccaneers

8:25 pm • CBS

San Francisco 49ers

@

Tampa Bay Buccaneers

MatchupOpenSpreadTotalMoneyline
49ers 4-1	+1.5	+3-108	o45.5-110	+140
Buccaneers 3-1	u48.5	-3-112	u45.5-110	-170

location pin

Sunday 8:25 p.m.

October 12, 2025

Raymond James StadiumTampa

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84°Fahrenheit

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8%Rain

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9Wind

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NFL Public Betting

Buccaneers are 3-1 in their last 5 games.
Buccaneers are 2-2 in their last 5 games against the spread
Buccaneers are 2-0 in their road games against the spread
The totals have gone OVER in 2 of Buccaneers' last 4 games
The totals have gone OVER in 2 of Buccaneers' 2 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Buccaneers	2-2	0-2	2-0	1-1	1-1
49ers	3-2	0-2	3-0	2-2	1-0

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Buccaneers	2-2	2-0	0-2	1-1	1-1
49ers	3-2	1-1	2-1	2-2	1-0

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Buccaneers	3-1	N/A	N/A	2-0	1-1
49ers	4-1	N/A	N/A	3-1	1-0

date	opponent	score	spread	over/under	moneyline
Sep 28th	PHI	L 25-31	+3.5 L	O 44.5	PHI +160
Sep 21st	NYJ	W 29-27	-6.5 L	O 43.5	TB -320
Sep 15th	@HOU	W 20-19	+2.5 W	U 42.5	TB +130
Sep 7th	@ATL	W 23-20	-1.5 W	U 47.5	TB -110
Aug 23rd	BUF	L 19-23	+1.5 L	O 37.5	BUF +105

Mike Evans
WR
Evans is out with hamstring
Out
Ko Kieft
TE
Kieft is out with leg
Out
Christian Izien
S
Izien is out with oblique
Out
Bucky Irving
RB
Irving is out with foot
Out
Benjamin Morrison
CB
Morrison is out with quad
Out

George Kittle
TE
Kittle is out with hamstring
Out
Brandon Aiyuk
WR
Aiyuk is out with knee
Out
Jauan Jennings
WR
Jennings is out with ankle
Out
Brock Purdy
QB
Purdy is out with toe
Out
Ricky Pearsall
WR
Pearsall is out with knee
Out
Jacob Cowing
WR
Cowing is out with hamstring
Out

Jordan Watkins
WR
Watkins is doubtful with ankle
Doubtful
Jordan James
RB
James is doubtful with finger
Doubtful

See more NFL Injuries

passing yards
Baker Mayfield
904
pyds
passing touchdowns
Baker Mayfield
8
ptd
rushing yards
Bucky Irving
237
ryds
rushing touchdowns
Rachaad White
1
rtd

	Starter	2ND	3RD	4TH
QB	Baker Mayfield	Teddy Bridgewater	Connor Bazelak
RB	Bucky Irving	Rachaad White	Sean Tucker	Josh Williams
WR	Chris Godwin	Emeka Egbuka	Sterling Shepard	Kameron Johnson
TE	Cade Otton	Payne Durham	Devin Culp	Ko Kieft	Tanner Taula
LT	Tristan Wirfs	Charlie Heck	Benjamin Chukwuma	Lorenz Metz
LG	Ben Bredeson	Elijah Klein
C	Graham Barton	Ben Scott
RG	Cody Mauch	Luke Haggard	Sua Opeta
RT	Luke Goedeke	Michael Jordan	Tyler McLellan
LDE	Logan Hall	Elijah Roberts
RDE	Calijah Kancey	C.J. Brewer	Adam Gotsis
LCB	Zyon McCollum	Josh Hayes
SS	Tykee Smith	Kaevon Merriweather	Rashad Wisdom
FS	Antoine Winfield
RCB	Jamel Dean	Benjamin Morrison	Bryce Hall
P	Riley Dixon
H	Riley Dixon
PR	Tez Johnson	Garrett Greene
KR	Sean Tucker	Garrett Greene
LS	Evan Deckers
LILB	Lavonte David	Deion Jones	Nick Jackson
LOLB	Haason Reddick	Anthony Nelson	Markees Watts
ROLB	Yaya Diaby	Chris Braswell
LWR	Mike Evans	Ryan Miller	Dennis Houston
RWR	Jalen McMillan	Tez Johnson	Garrett Greene
RILB	SirVocea Dennis	John Bullock
K	Chase McLaughlin
NT	Vita Vea	Greg Gaines	Desmond Watson	Nash Hutmacher
NB	Jacob Parrish	Christian Izien	Kindle Vildor

Total

Passing

1453

YDS

847

134/202

Comps/Atts

83/139

7.381

YPA

6.504

10/5

TDs/INTs

8/1

7/38

Sacks/Yards

8/57

Rushing

426

Rush Yards

496

139

Attempts

113

3.065

YPC

4.389

0

TDs

1

Turnovers

Fumbles Lost

5

Interceptions

1

Efficiency

8/19 42.11%

Redzone

4/11 36.36%

32/70 0%

3rd Down

20/54 0%

6/8 0%

4th Down

3/5 0%

First Downs

115

Total

78

80

Pass

41

25

Rush

23

10

Penalty

14

Misc

/

Penalties/Yards

/

Possession

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MatchupOverUnder
49ers 4-1	N/A	N/A
Buccaneers 3-1	N/A	N/A