49ers vs. Buccaneers Odds & Betting Predictions - October 12, 2025

49ers at Buccaneers

8:25 pm • CBS

San Francisco 49ers

5-3

19 - 30

Tampa Bay Buccaneers

6-2

MatchupOpenSpreadTotalMoneyline
49ers 5-3	+1.5	+3.5-110	o47-110	+160
Buccaneers 6-2	u48.5	-3.5-110	u47-110	-190

Sunday 8:25 p.m.

October 12, 2025

Raymond James StadiumTampa

SF +6.5 (Live)-102

0.1u

Why not

SF +3.5 (Live)+111

SF +2.5 (Live)+100

C.McCaffrey u12.5 Longest Rush-115

0.25u

Tailing @nick_giffen

C.McCaffrey u12.5 Longest Rush-115

0.5u

Discord prop

T.Smith o6.5 Tackles + Ast-108

0.27u

Tailing @The_Oddsmaker

T.Smith o6.5 Tackles + Ast-108

0.54u

Projecting closer to 7.6 with around a 60% chance to go over 6.5

Under 47-110

1.25u

SF +3.5-110

0.55u

Action IG channel best bet - let’s tail!

Over 46.5-116

0.86u

Over 47.5-108

Under 47.5-105

SF +3.5-120

1.2u

C.Otton o29.5 Rec Yds-114

0.88u

SF +3.5-110

1.1u

SF +3.5-112

SF +150

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R.White o24.5 Rec Yds-108

E.Egbuka Anytime TD Scorer Yes+135

0.5u

@GDAWG5000 https://myaction.app/QzEiDAmkmXb

D.Robinson Anytime TD Scorer Yes+450

0.5u

@GDAWG5000 https://myaction.app/QzEiDAmkmXb

R.White o3.5 Recs-120

TB -150

0.17u

Took piece off 49ers after Mac Jones didn’t throw yesterday. Shanahan saying he “should be able to play” isn’t the most encouraging endorsement. Can add back if all good. Looks like no Pearsall. Jennings limited has a chance.

SF +3+100

@Stuckey2 https://myaction.app/62yRjm1UlXb

TB -3-107

SF +3-110

1.1u

SF +3-105

@sundaysixpack @Stuckey2 https://myaction.app/S6McBO2wkXb

SF +3-105

1.05u

@Stuckey2 1 https://myaction.app/S6McBO2wkXb

C.McCaffrey u50 Rec Yds+100

B.Mayfield Anytime TD Scorer Yes+450

0.1u

Under 47.5-108

SF +3-105

0.6u

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NFL Public Betting

Buccaneers are 4-1 in their last 5 games.
Buccaneers are 3-2 in their last 5 games against the spread
Buccaneers are 4-1 in their road games against the spread
The totals have gone OVER in 3 of Buccaneers' last 5 games
The totals have gone OVER in 3 of Buccaneers' 3 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Buccaneers	5-3	1-2	4-1	3-1	2-2
49ers	4-4	1-2	3-2	2-2	2-2

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Buccaneers	4-4	3-0	1-4	2-2	2-2
49ers	4-4	1-2	3-2	2-2	2-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Buccaneers	6-2	N/A	N/A	4-0	2-2
49ers	5-3	N/A	N/A	3-1	2-2

date	opponent	score	spread	over/under	moneyline
Oct 5th	@SEA	W 38-35	+3.5 W	O 44.5	TB +165
Sep 28th	PHI	L 25-31	+3.5 L	O 44.5	PHI +160
Sep 21st	NYJ	W 29-27	-6.5 L	O 43.5	TB -320
Sep 15th	@HOU	W 20-19	+2.5 W	U 42.5	TB +130
Sep 7th	@ATL	W 23-20	-1.5 W	U 47.5	TB -110

Mike Evans
WR
Evans is out with collarbone
Out
Chris Godwin
WR
Godwin is out with leg
Out
Ko Kieft
TE
Kieft is out with leg
Out
Christian Izien
S
Izien is out with oblique
Out
Bucky Irving
RB
Irving is out with foot
Out
Benjamin Morrison
CB
Morrison is out with quad
Out

Brandon Aiyuk
WR
Aiyuk is out with knee
Out

Brock Purdy
QB
Purdy is questionable with toe
Questionable
Ricky Pearsall
WR
Pearsall is questionable with knee
Questionable
Jacob Cowing
WR
Cowing is out with hamstring
Out
Jordan James
RB
James is doubtful with finger
Doubtful

See more NFL Injuries

49ers

Total

Buccaneers

363

Total Yards

352

Total Plays

5.4

Yards Per Play

49ers

Passing

Buccaneers

347

YDS

256

27/39

Comps/Atts

17/23

6.578

YPA

10.333

0/2

TDs/INTs

2/0

6/51

Sacks/Yards

1/8

49ers

Rushing

Buccaneers

Rush Yards

104

Attempts

3.045

YPC

TDs

49ers

Turnovers

Buccaneers

Fumbles Lost

Interceptions

49ers

Efficiency

Buccaneers

1/2 50%

Redzone

2/2 100%

7/16 0%

3rd Down

3/8 0%

0/2 0%

4th Down

0/0 0%

49ers

First Downs

Buccaneers

Total

Pass

Rush

Penalty

49ers

Misc

Buccaneers

9/65

Penalties/Yards

5/31

32:35

Possession

27:25

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MatchupOverUnder
49ers 5-3	o21.5-115	u21.5-108
Buccaneers 6-2	o25.5-116	u25.5-106

49ers vs. Buccaneers Odds & Betting Predictions - October 12, 2025

49ers at Buccaneers

San Francisco 49ers

Tampa Bay Buccaneers

49ers at Buccaneers Odds

Spread, Total, Moneyline

49ers vs. Buccaneers Previews & Analysis

49ers vs. Bucs: Will Mayfield Magic Run Out?

Sunday's Top Upset Pick

PRO Digs Up 17-1 ATD Edge Sunday

Gallant's Anytime TD Picks for Every NFL Game

49ers vs. Buccaneers Props

Prop Projections

Prop Odds Comparison

Line Movement Tracker

49ers vs. Buccaneers Public Betting Percentages

49ers

Public

Buccaneers

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

Buccaneers vs. 49ers Injury Updates

Buccaneers Injuries

49ers Injuries

49ers vs. Buccaneers Odds Comparison

49ers at Buccaneers Team Totals