49ers vs. Buccaneers Odds & Betting Predictions - October 12, 2025
49ers at Buccaneers
8:25 pm • CBS49ers at Buccaneers Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
49ers 5-3 | +1.5 | +3.5-110 | o47-110 | +160 |
Buccaneers 6-2 | u48.5 | -3.5-110 | u47-110 | -190 |

Raymond James StadiumTampa
49ers vs. Buccaneers Expert Picks
Stuck 🚨
Last 30d: 53-60-0 (-1.4u)
SF +6.5 (Live)-102
0.1u
Why not
Boomer Betz
Last 30d: 170-173-2 (+4.6u)
SF +3.5 (Live)+111
1u
FTN Fantasy
Last 30d: 43-43-0 (+1.8u)
SF +2.5 (Live)+100
1u
Allan Lem
Last 30d: 139-106-3 (+7.8u)
C.McCaffrey u12.5 Longest Rush-115
0.25u
Tailing @nick_giffen
Nick Giffen
Last 30d: 41-60-0 (+5.2u)
C.McCaffrey u12.5 Longest Rush-115
0.5u
Discord prop
Allan Lem
Last 30d: 139-106-3 (+7.8u)
T.Smith o6.5 Tackles + Ast-108
0.27u
Tailing @The_Oddsmaker
Sean Koerner
Last 30d: 48-34-0 (+7.4u)
T.Smith o6.5 Tackles + Ast-108
0.54u
Projecting closer to 7.6 with around a 60% chance to go over 6.5
Wags Wins
Last 30d: 217-216-1 (-12.4u)
Under 47-110
1.25u
Allan Lem
Last 30d: 139-106-3 (+7.8u)
SF +3.5-110
0.55u
Action IG channel best bet - let’s tail!
Scott Rickenbach
Last 30d: 105-110-1 (-16.9u)
Over 46.5-116
0.86u
The Degenerates
Last 30d: 54-56-0 (-6.3u)
Over 47.5-108
1u
Mjaybrod
Last 30d: 81-101-0 (-12.0u)
Under 47.5-105
1u
Bet Labs
Last 30d: 20-19-0 (+2.4u)
SF +3.5-120
1.2u
Babs .
Last 30d: 94-110-3 (-11.7u)
C.Otton o29.5 Rec Yds-114
0.88u
Vegas Refund
Last 30d: 35-34-1 (-2.5u)
SF +3.5-110
1.1u
Brian Bitler
Last 30d: 70-76-2 (-27.4u)
SF +3.5-112
3u
Moneyline Hacks
Last 30d: 116-127-2 (+37.6u)
SF +150
1u
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Babs .
Last 30d: 94-110-3 (-11.7u)
R.White o24.5 Rec Yds-108
1u
TAN Pod Touchdown Show
Last 30d: 20-73-2 (-7.7u)
E.Egbuka Anytime TD Scorer Yes+135
0.5u
@GDAWG5000 https://myaction.app/QzEiDAmkmXb
D.Robinson Anytime TD Scorer Yes+450
0.5u
@GDAWG5000 https://myaction.app/QzEiDAmkmXb
The Propfessor
Last 30d: 38-50-0 (+4.3u)
R.White o3.5 Recs-120
1u
Stuck 🚨
Last 30d: 53-60-0 (-1.4u)
TB -150
0.17u
Took piece off 49ers after Mac Jones didn’t throw yesterday. Shanahan saying he “should be able to play” isn’t the most encouraging endorsement. Can add back if all good. Looks like no Pearsall. Jennings limited has a chance.
The Favorites Podcast
Last 30d: 8-13-0 (-3.9u)
SF +3+100
1u
@Stuckey2 https://myaction.app/62yRjm1UlXb
Kenny Ducey
Last 30d: 17-22-0 (-7.2u)
TB -3-107
1u
Matt Moore
Last 30d: 40-46-0 (-2.5u)
SF +3-110
1.1u
Action Pod NFL Picks
Last 30d: 59-118-0 (-3.3u)
SF +3-105
1u
@sundaysixpack @Stuckey2 https://myaction.app/S6McBO2wkXb
Sunday Six Pack
Last 30d: 11-13-0 (-3.4u)
SF +3-105
1.05u
@Stuckey2 1 https://myaction.app/S6McBO2wkXb
Boomer Betz
Last 30d: 170-173-2 (+4.6u)
C.McCaffrey u50 Rec Yds+100
1u
💰🦡 Jake
Last 30d: 104-120-8 (+0.2u)
B.Mayfield Anytime TD Scorer Yes+450
0.1u
Boomer Betz
Last 30d: 170-173-2 (+4.6u)
Under 47.5-108
1u
Stuck 🚨
Last 30d: 53-60-0 (-1.4u)
SF +3-105
0.6u
49ers vs. Buccaneers Previews & Analysis
49ers vs. Buccaneers Props
Prop Projections
There are no prop projections found for the selected slate. Please check back later.
Prop Odds Comparison
Line Movement Tracker
49ers vs. Buccaneers Public Betting Percentages
Betting Trends
- Buccaneers are 4-1 in their last 5 games.
- Buccaneers are 3-2 in their last 5 games against the spread
- Buccaneers are 4-1 in their road games against the spread
- The totals have gone OVER in 3 of Buccaneers' last 5 games
- The totals have gone OVER in 3 of Buccaneers' 3 last games at home
Matchup History
Against the Spread (ATS) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 5-3 | 1-2 | 4-1 | 3-1 | 2-2 | |
| 4-4 | 1-2 | 3-2 | 2-2 | 2-2 |
Over/Under History
| overall | home o/u | away o/u | favorite o/u | underdog o/u | |
|---|---|---|---|---|---|
| 4-4 | 3-0 | 1-4 | 2-2 | 2-2 | |
| 4-4 | 1-2 | 3-2 | 2-2 | 2-2 |
Straight-Up (ML) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 6-2 | N/A | N/A | 4-0 | 2-2 | |
| 5-3 | N/A | N/A | 3-1 | 2-2 |
Last 5 Matchups
Buccaneers vs. 49ers Injury Updates

Buccaneers Injuries
- Mike EvansWR
Evans is out with collarbone
Out
- Chris GodwinWR
Godwin is out with leg
Out
- Ko KieftTE
Kieft is out with leg
Out
- Christian IzienS
Izien is out with oblique
Out
- Bucky IrvingRB
Irving is out with foot
Out
- Benjamin MorrisonCB
Morrison is out with quad
Out

49ers Injuries
- Brandon AiyukWR
Aiyuk is out with knee
Out
- Brock PurdyQB
Purdy is questionable with toe
Questionable
- Ricky PearsallWR
Pearsall is questionable with knee
Questionable
- Jacob CowingWR
Cowing is out with hamstring
Out
- Jordan JamesRB
James is doubtful with finger
Doubtful
Team Stats
49ers vs. Buccaneers Odds Comparison
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49ers at Buccaneers Team Totals
MatchupOverUnder | ||
|---|---|---|
49ers 5-3 | o21.5-115 | u21.5-108 |
Buccaneers 6-2 | o25.5-116 | u25.5-106 |




