49ers vs. Buccaneers Odds & Betting Predictions - October 12, 2025

49ers at Buccaneers

8:25 pm • CBS
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49ers at Buccaneers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
49ers
4-1
+1.5
+3-108
o45.5-110
+140
Buccaneers
3-1
u48.5
-3-112
u45.5-110
-170
location pinSunday 8:25 p.m.
October 12, 2025
Raymond James StadiumTampa
thermometer image84°Fahrenheit
rain image8%Rain
wind image9Wind

49ers vs. Buccaneers Props

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49ers vs. Buccaneers Public Betting Percentages

Away Logo

49ers

Public

100%

Bets%

0%

Money%

NFL Public Betting Right Arrow

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Buccaneers
2-20-22-01-11-1
49ers
3-20-23-02-21-0

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Buccaneers
2-22-00-21-11-1
49ers
3-21-12-12-21-0

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Buccaneers
3-1N/AN/A2-01-1
49ers
4-1N/AN/A3-11-0

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 28thPHIL 25-31+3.5 LO 44.5PHI +160
Sep 21stNYJW 29-27-6.5 LO 43.5TB -320
Sep 15th@HOUW 20-19+2.5 WU 42.5TB +130
Sep 7th@ATLW 23-20-1.5 WU 47.5TB -110
Aug 23rdBUFL 19-23+1.5 LO 37.5BUF +105

Buccaneers vs. 49ers Injury Updates

Buccaneers Injuries

  • Mike Evans
    WR

    Evans is out with hamstring

    Out

  • Ko Kieft
    TE

    Kieft is out with leg

    Out

  • Christian Izien
    S

    Izien is out with oblique

    Out

  • Bucky Irving
    RB

    Irving is out with foot

    Out

  • Benjamin Morrison
    CB

    Morrison is out with quad

    Out

49ers Injuries

  • George Kittle
    TE

    Kittle is out with hamstring

    Out

  • Brandon Aiyuk
    WR

    Aiyuk is out with knee

    Out

  • Jauan Jennings
    WR

    Jennings is out with ankle

    Out

  • Brock Purdy
    QB

    Purdy is out with toe

    Out

  • Ricky Pearsall
    WR

    Pearsall is out with knee

    Out

  • Jacob Cowing
    WR

    Cowing is out with hamstring

    Out

  • Jordan Watkins
    WR

    Watkins is doubtful with ankle

    Doubtful

  • Jordan James
    RB

    James is doubtful with finger

    Doubtful

Player Stats
  • passing yards
    Baker Mayfield logo
    Baker Mayfield
    904
    pyds
  • passing touchdowns
    Baker Mayfield logo
    Baker Mayfield
    8
    ptd
  • rushing yards
    Bucky Irving logo
    Bucky Irving
    237
    ryds
  • rushing touchdowns
    Rachaad White logo
    Rachaad White
    1
    rtd
Depth Charts
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Starter2ND3RD4TH
QBBaker MayfieldTeddy BridgewaterConnor Bazelak
RBBucky IrvingRachaad WhiteSean TuckerJosh Williams
WRChris GodwinEmeka EgbukaSterling ShepardKameron Johnson
TECade OttonPayne DurhamDevin CulpKo KieftTanner Taula
LTTristan WirfsCharlie HeckBenjamin ChukwumaLorenz Metz
LGBen BredesonElijah Klein
CGraham BartonBen Scott
RGCody MauchLuke HaggardSua Opeta
RTLuke GoedekeMichael JordanTyler McLellan
LDELogan HallElijah Roberts
RDECalijah KanceyC.J. BrewerAdam Gotsis
LCBZyon McCollumJosh Hayes
SSTykee SmithKaevon MerriweatherRashad Wisdom
FSAntoine Winfield
RCBJamel DeanBenjamin MorrisonBryce Hall
PRiley Dixon
HRiley Dixon
PRTez JohnsonGarrett Greene
KRSean TuckerGarrett Greene
LSEvan Deckers
LILBLavonte DavidDeion JonesNick Jackson
LOLBHaason ReddickAnthony NelsonMarkees Watts
ROLBYaya DiabyChris Braswell
LWRMike EvansRyan MillerDennis Houston
RWRJalen McMillanTez JohnsonGarrett Greene
RILBSirVocea DennisJohn Bullock
KChase McLaughlin
NTVita VeaGreg GainesDesmond WatsonNash Hutmacher
NBJacob ParrishChristian IzienKindle Vildor
Team Stats
1453
YDS
847
134/202
Comps/Atts
83/139
7.381
YPA
6.504
10/5
TDs/INTs
8/1
7/38
Sacks/Yards
8/57
426
Rush Yards
496
139
Attempts
113
3.065
YPC
4.389
0
TDs
1
Fumbles Lost
5
Interceptions
1

Efficiency

8/19 42.11%
Redzone
4/11 36.36%
32/70 0%
3rd Down
20/54 0%
6/8 0%
4th Down
3/5 0%

First Downs

115
Total
78
80
Pass
41
25
Rush
23
10
Penalty
14
/
Penalties/Yards
/
Possession

49ers vs. Buccaneers Odds Comparison

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49ers at Buccaneers Team Totals

MatchupOverUnder
49ers
4-1
N/A
N/A
Buccaneers
3-1
N/A
N/A