49ers vs. Buccaneers Odds & Betting Predictions - October 12, 2025

49ers at Buccaneers

8:25 pm • CBS
19 - 30

49ers at Buccaneers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
49ers
5-3
+1.5
+3.5-110
o47-110
+160
Buccaneers
6-2
u48.5
-3.5-110
u47-110
-190
location pinSunday 8:25 p.m.
October 12, 2025
Raymond James StadiumTampa
49ers vs. Buccaneers Expert Picks
Stuck 🚨
Stuck 🚨
Last 30d: 53-60-0 (-1.4u)
SF +6.5 (Live)-102
0.1u
Why not
Boomer Betz
Boomer Betz
Last 30d: 170-173-2 (+4.6u)
SF +3.5 (Live)+111
1u
FTN Fantasy
FTN Fantasy
Last 30d: 43-43-0 (+1.8u)
SF +2.5 (Live)+100
1u
Allan Lem
Allan Lem
Last 30d: 139-106-3 (+7.8u)
C.McCaffrey u12.5 Longest Rush-115
0.25u
Tailing @nick_giffen
Nick Giffen
Nick Giffen
Last 30d: 41-60-0 (+5.2u)
C.McCaffrey u12.5 Longest Rush-115
0.5u
Discord prop
Allan Lem
Allan Lem
Last 30d: 139-106-3 (+7.8u)
T.Smith o6.5 Tackles + Ast-108
0.27u
Tailing @The_Oddsmaker
Sean Koerner
Sean Koerner
Last 30d: 48-34-0 (+7.4u)
T.Smith o6.5 Tackles + Ast-108
0.54u
Projecting closer to 7.6 with around a 60% chance to go over 6.5
Wags Wins
Wags Wins
Last 30d: 217-216-1 (-12.4u)
Under 47-110
1.25u
Allan Lem
Allan Lem
Last 30d: 139-106-3 (+7.8u)
SF +3.5-110
0.55u
Action IG channel best bet - let’s tail!
Scott Rickenbach
Scott Rickenbach
Last 30d: 105-110-1 (-16.9u)
Over 46.5-116
0.86u
The Degenerates
The Degenerates
Last 30d: 54-56-0 (-6.3u)
Over 47.5-108
1u
Mjaybrod
Mjaybrod
Last 30d: 81-101-0 (-12.0u)
Under 47.5-105
1u
Bet Labs
Bet Labs
Last 30d: 20-19-0 (+2.4u)
SF +3.5-120
1.2u
Babs .
Babs .
Last 30d: 94-110-3 (-11.7u)
C.Otton o29.5 Rec Yds-114
0.88u
Vegas Refund
Vegas Refund
Last 30d: 35-34-1 (-2.5u)
SF +3.5-110
1.1u
Brian Bitler
Brian Bitler
Last 30d: 70-76-2 (-27.4u)
SF +3.5-112
3u
Moneyline Hacks
Moneyline Hacks
Last 30d: 116-127-2 (+37.6u)
SF +150
1u
🚨Free analysis & VIP Picks can be found on our Discord. Link: https://discord.gg/JrzjtqdVfA 🎙️Fade the Noise PODCAST - Subscribe!✅ https://www.youtube.com/@FadetheNoise 🔥50% OFF VIP!! ⬇️⬇️ (COPY & PASTE LINK): https://dubclub.win/r/p/pri-r744p/?checkout=1&coupon=ValueHacks50
Babs .
Babs .
Last 30d: 94-110-3 (-11.7u)
R.White o24.5 Rec Yds-108
1u
TAN Pod Touchdown Show
TAN Pod Touchdown Show
Last 30d: 20-73-2 (-7.7u)
E.Egbuka Anytime TD Scorer Yes+135
0.5u
D.Robinson Anytime TD Scorer Yes+450
0.5u
The Propfessor
The Propfessor
Last 30d: 38-50-0 (+4.3u)
R.White o3.5 Recs-120
1u
Stuck 🚨
Stuck 🚨
Last 30d: 53-60-0 (-1.4u)
TB -150
0.17u
Took piece off 49ers after Mac Jones didn’t throw yesterday. Shanahan saying he “should be able to play” isn’t the most encouraging endorsement. Can add back if all good. Looks like no Pearsall. Jennings limited has a chance.
The Favorites Podcast
The Favorites Podcast
Last 30d: 8-13-0 (-3.9u)
SF +3+100
1u
Kenny Ducey
Kenny Ducey
Last 30d: 17-22-0 (-7.2u)
TB -3-107
1u
Matt Moore
Matt Moore
Last 30d: 40-46-0 (-2.5u)
SF +3-110
1.1u
Action Pod NFL Picks
Action Pod NFL Picks
Last 30d: 59-118-0 (-3.3u)
SF +3-105
1u
@sundaysixpack @Stuckey2 https://myaction.app/S6McBO2wkXb
Sunday Six Pack
Sunday Six Pack
Last 30d: 11-13-0 (-3.4u)
SF +3-105
1.05u
Boomer Betz
Boomer Betz
Last 30d: 170-173-2 (+4.6u)
C.McCaffrey u50 Rec Yds+100
1u
💰🦡 Jake
💰🦡 Jake
Last 30d: 104-120-8 (+0.2u)
B.Mayfield Anytime TD Scorer Yes+450
0.1u
Boomer Betz
Boomer Betz
Last 30d: 170-173-2 (+4.6u)
Under 47.5-108
1u
Stuck 🚨
Stuck 🚨
Last 30d: 53-60-0 (-1.4u)
SF +3-105
0.6u

49ers vs. Buccaneers Previews & Analysis

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49ers vs. Buccaneers Props

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49ers vs. Buccaneers Public Betting Percentages

Away Logo

49ers

Public

56%

Bets%

44%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Buccaneers
5-31-24-13-12-2
49ers
4-41-23-22-22-2

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Buccaneers
4-43-01-42-22-2
49ers
4-41-23-22-22-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Buccaneers
6-2N/AN/A4-02-2
49ers
5-3N/AN/A3-12-2

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Oct 5th@SEAW 38-35+3.5 WO 44.5TB +165
Sep 28thPHIL 25-31+3.5 LO 44.5PHI +160
Sep 21stNYJW 29-27-6.5 LO 43.5TB -320
Sep 15th@HOUW 20-19+2.5 WU 42.5TB +130
Sep 7th@ATLW 23-20-1.5 WU 47.5TB -110

Buccaneers vs. 49ers Injury Updates

Buccaneers Injuries

  • Mike Evans
    WR

    Evans is out with collarbone

    Out

  • Chris Godwin
    WR

    Godwin is out with leg

    Out

  • Ko Kieft
    TE

    Kieft is out with leg

    Out

  • Christian Izien
    S

    Izien is out with oblique

    Out

  • Bucky Irving
    RB

    Irving is out with foot

    Out

  • Benjamin Morrison
    CB

    Morrison is out with quad

    Out

49ers Injuries

  • Brandon Aiyuk
    WR

    Aiyuk is out with knee

    Out

  • Brock Purdy
    QB

    Purdy is questionable with toe

    Questionable

  • Ricky Pearsall
    WR

    Pearsall is questionable with knee

    Questionable

  • Jacob Cowing
    WR

    Cowing is out with hamstring

    Out

  • Jordan James
    RB

    James is doubtful with finger

    Doubtful

Team Stats
363
Total Yards
352
67
Total Plays
50
5.4
Yards Per Play
7
347
YDS
256
27/39
Comps/Atts
17/23
6.578
YPA
10.333
0/2
TDs/INTs
2/0
6/51
Sacks/Yards
1/8
67
Rush Yards
104
22
Attempts
26
3.045
YPC
4
1
TDs
2
0
Fumbles Lost
0
2
Interceptions
0

Efficiency

1/2 50%
Redzone
2/2 100%
7/16 0%
3rd Down
3/8 0%
0/2 0%
4th Down
0/0 0%

First Downs

17
Total
19
10
Pass
9
6
Rush
9
1
Penalty
1
9/65
Penalties/Yards
5/31
32:35
Possession
27:25

49ers vs. Buccaneers Odds Comparison

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49ers at Buccaneers Team Totals

MatchupOverUnder
49ers
5-3
o21.5-115
u21.5-108
Buccaneers
6-2
o25.5-116
u25.5-106