Panthers vs. 49ers Odds & Betting Predictions - November 25, 2025

Panthers at 49ers

1:15 am • ESPN

Carolina Panthers

San Francisco 49ers

MatchupOpenSpreadTotalMoneyline
Panthers 6-5	+7	+7.5-115	o49.5-112	+300
49ers 7-4	u46.5	-7.5-105	u49.5-109	-375

Tuesday 1:15 a.m.

November 25, 2025

Levi's StadiumSanta Clara

58°Fahrenheit

0%Rain

3Wind

B.Purdy o7.5 Rush Yds-110

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K.Juszczyk Anytime TD Scorer Yes+1000

0.3u

B.Purdy Anytime TD Scorer Yes+500

0.5u

J.Jennings Anytime TD Scorer Yes+225

0.5u

X.Legette Anytime TD Scorer Yes+450

0.5u

SF u30.5-125

1.25u

@braydenhenry

X.Legette Anytime TD Scorer Yes+400

0.5u

@ChrisRaybon https://myaction.app/XiJckG31tYb

J.Jennings Anytime TD Scorer Yes+195

0.5u

@GDAWG5000 https://myaction.app/XiJckG31tYb

B.Robinson Anytime TD Scorer Yes+450

0.5u

@The_Oddsmaker https://myaction.app/XiJckG31tYb

B.Robinson o21.5 Rush Yds-110

0.5u

T.McMillan o61.5 Rec Yds-115

0.5u

CAR +7-110

1.1u

G.Kittle o54.5 Rec Yds-117

Over 47.5-111

1.11u

FD. Should close closer to 49

CAR +7+100

0.5u

SF -7-112

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NFL Public Betting

49ers are 2-3 in their last 5 games.
49ers are 2-3 in their last 5 games against the spread
49ers are 5-2 in their road games against the spread
The totals have gone OVER in 3 of 49ers' last 5 games
The totals have gone OVER in 2 of 49ers' 4 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
49ers	6-5	1-3	5-2	4-2	2-3
Panthers	7-4	3-2	4-2	0-1	7-3

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
49ers	7-4	2-2	5-2	4-2	3-2
Panthers	6-5	3-2	3-3	0-1	6-4

Straight-Up (ML) History

	overall	home	away	favorite	underdog
49ers	7-4	N/A	N/A	5-1	2-3
Panthers	6-5	N/A	N/A	0-1	6-4

date	opponent	score	spread	over/under	moneyline
Nov 16th	@ARI	W 41-22	-	-	-
Nov 9th	LA	L 26-42	-	-	-
Nov 2nd	@NYG	W 34-24	-	-	-
Oct 26th	@HOU	L 15-26	-	-	-
Oct 20th	ATL	W 20-10	-	-	-

Brandon Aiyuk
WR
Aiyuk is out with knee
Out
Jacob Cowing
WR
Cowing is out with hamstring
Out

Jordan James
RB
James is doubtful with finger
Doubtful

David Moore
WR
Moore is out with elbow
Out
Damarri Mathis
CB
Mathis is out with knee
Out

See more NFL Injuries

passing yards
Mac Jones
2151
pyds
passing touchdowns
Mac Jones
13
ptd
rushing yards
Christian McCaffrey
707
ryds
rushing touchdowns
Christian McCaffrey
6
rtd

	Starter	2ND	3RD	4TH
QB	Brock Purdy	Mac Jones	Kurtis Rourke
RB	Christian McCaffrey	Isaac Guerendo	Jordan James
WR	Jauan Jennings	Jacob Cowing	Skyy Moore	Junior Bergen
TE	George Kittle	Luke Farrell	Jake Tonges	Brayden Willis
LT	Trent Williams	Spencer Burford
LG	Ben Bartch	Nick Zakelj
C	Jake Brendel	Matt Hennessy	Drake Nugent
RG	Dominick Puni	Connor Colby
RT	Colton McKivitz	Austen Pleasants
LDE	Nick Bosa	Yetur Gross-Matos	Robert Beal	William Bradley-King
RDE	Mykel Williams	Bryce Huff	Sam Okuayinonu
WLB	Dee Winters	Nick Martin	Stone Blanton	Jalen Graham
MLB	Fred Warner	Luke Gifford	Tatum Bethune	Curtis Robinson
LCB	Renardo Green	Jakob Robinson
SS	Ji'Ayir Brown	Malik Mustapha	Derrick Canteen
FS	Jason Pinnock	Marques Sigle	Siran Neal
RCB	Deommodore Lenoir	Darrell Luter
P	Thomas Morstead
PR	Jacob Cowing	Junior Bergen	Jordan Watkins	Ricky Pearsall
KR	Isaac Guerendo	Junior Bergen
LS	Jon Weeks
NT	Jordan Elliott	C.J. West	Kalia Davis
NB	Upton Stout	Chase Lucas
LWR	Brandon Aiyuk	Malik Turner
RWR	Ricky Pearsall	Jordan Watkins	Malik Turner
DT	Kevin Givens	Alfred Collins	Sebastian Valdez	Evan Anderson
FB	Kyle Juszczyk

Total

Passing

2059

YDS

2800

222/351

Comps/Atts

268/388

6.425

YPA

7.57

15/8

TDs/INTs

20/10

27/196

Sacks/Yards

19/137

Panthers

Rushing

49ers

1398

Rush Yards

1043

317

Attempts

295

4.41

YPC

3.536

TDs

Panthers

Turnovers

49ers

Fumbles Lost

Interceptions

Panthers

Efficiency

49ers

19/35 54.29%

Redzone

25/40 62.5%

51/138 0%

3rd Down

63/138 0%

18/27 0%

4th Down

8/15 0%

Panthers

First Downs

49ers

220

Total

240

121

Pass

152

Rush

Penalty

Panthers

Misc

49ers

Penalties/Yards

Possession

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MatchupOverUnder
Panthers 6-5	N/A	N/A
49ers 7-4	N/A	N/A

Panthers vs. 49ers Odds & Betting Predictions - November 25, 2025

Panthers at 49ers

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Panthers vs. 49ers Props

Prop Projections

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Line Movement Tracker

Panthers vs. 49ers Public Betting Percentages

Panthers

Public

49ers

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

49ers vs. Panthers Injury Updates

49ers Injuries

Panthers Injuries

Panthers vs. 49ers Odds Comparison

Panthers at 49ers Team Totals