49ers vs. Cardinals Odds & Betting Predictions - November 16, 2025

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San Francisco may finally have the injury edge in a game. It looks like Brock Purdy should return at last, and maybe Ricky Pearsall as well, while Arizona is missing all sorts of bodies. Will Johnson and Walter Nolan are doubts in defense, Kyler Murray is out, and the weapons on offense are down to practice squad guys with Marvin Harrison and Zay Jones out, along with Arizona's top three running backs. About the only guy left is TE Trey McBride, and he's been an absolute superstar of late, finding incredible chemistry with Brissett. In four games together, McBride has 32 catches for 328 yards and five scores. He has at least one touchdown in every Brissett game, and these last four games would pace to an all-time tight end season: 135 catches for 1,400 yards and 21 TDs. McBride should get plenty of opportunity with so many teammates out, and the 49ers defense is ripe for the picking. It's been especially poor over the middle and against the slot, and it has allowed three TDs to tight ends in just the last two games. I looked at all of the McBride lines to invest, but his upside is mostly already priced in at receptions and yards. Touchdowns are more unreliable, but Arizona should score on this defense, and McBride is easily its most likely TD threat. Bet on an Anytime TD at +120 (Fanatics), a gift price with a plus in front of it for a guy this hot. In my Extra Point this week, I recommended McBride too — as the season leader for receiving touchdowns at +8000 (Caesars). Davante Adams leads with nine, a clear favorite with his red zone abilities, but he's playing with an oblique injury. Only Amon-Ra St. Brown and Dallas Goedert otherwise are ahead of McBride's six TDs, so if he keeps up this scoring pace with Brissett, he should be in the mix.

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