49ers vs. Rams Odds & Betting Predictions - September 22, 2024
49ers at Rams
8:25 pm • FOX49ers at Rams Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
---|---|---|---|---|
![]() 49ers 0-1 | -2.5 | -6-108 | o44.5-109 | -264 |
![]() Rams 1-0 | u49 | +6-112 | u44.5-111 | +215 |

SoFi StadiumInglewood
49ers vs. Rams Expert Picks

STL ELITE
Last 30d: 6-4-0 (+8.9u)
SF -0.5-120
3u
*** Teaser with Falcons +9 ***

Bet What Happens Live!
Last 30d: 18-32-0 (+0.3u)
LA +7.5 (Live)-115
1u

Ryan Sura
Last 30d: 33-47-3 (+19.4u)
LA +10.5 (Live)-125
1u

RocketPlays
Last 30d: 14-16-0 (-0.2u)
Under 44.5-106
1.06u

Top Shelf Action 🥃
Last 30d: 137-138-9 (-10.4u)
Under 22.5 (1H)-110
0.91u
#ProSystem
... 1H windy unders
Overall: 380-278-120,58% (ROI:10%)
Season:4-3-0,57% (ROI:6%)

Shady Biev
Last 30d: 0-1-0 (-3.0u)
K.Williams Anytime TD Scorer Yes-110
2u

Vegas Refund
Last 30d: 12-2-0 (+9.7u)
LA +6.5-110
1u

Moneyline Hacks
Last 30d: 75-77-3 (+10.4u)
M.Stafford o0.5 Rush Yds+115
2u

Top Shelf Action 🥃
Last 30d: 137-138-9 (-10.4u)
LA +3.5 (1H)-110
1u
#ProSystem
... 1H dog off bad loss
Overall: 192-105-6,65% (ROI:25%)
Season:0-0-0, 0% (ROI: 0%)

Moneyline Hacks
Last 30d: 75-77-3 (+10.4u)
LA +6.5-110
0.91u

The Touchdown Show
Last 30d: 0-0-0 (+0.0u)
B.Aiyuk Anytime TD Scorer Yes+130
1u
@TheBMatt
B.Corum Anytime TD Scorer Yes+1100
0.25u
@GDAWG5000

Greg Matherne
Last 30d: 10-23-0 (+2.3u)
Under 44.5-110
0.55u

JB Bets
Last 30d: 0-0-0 (+0.0u)
J.Mason 90+ Rushing Yards Yes-125
1u
YBK Picks.com
Last 30d: 9-20-2 (-21.9u)
LA +6.5-105
1.9u

Sean Zerillo
Last 30d: 135-158-6 (-0.4u)
Under 44.5-110
0.55u

Kyle Just Bets
Last 30d: 0-0-0 (+0.0u)
J.Mason o89.5 Rush Yds-117
1u

Brian Matthews
Last 30d: 0-0-0 (+0.0u)
B.Aiyuk Anytime TD Scorer Yes+120
1u
Mild pick for today’s TD show

Prop Bet Guy
Last 30d: 0-0-0 (+0.0u)
C.Parkinson u14.5 Longest Reception-110
1u

Brian Bitler
Last 30d: 70-72-1 (-3.5u)
LA +6.5-110
2.73u

Top Shelf Action 🥃
Last 30d: 137-138-9 (-10.4u)
Under 44-108
1u
#ProSystem

Sandy Plashkes
Last 30d: 54-69-0 (-3.8u)
LA +6.5-110
1u

Shady Biev
Last 30d: 0-1-0 (-3.0u)
LA +6.5-112
2u

Steak Friend
Last 30d: 0-0-0 (+0.0u)
LA +7.5-125
1u

Chad Millman
Last 30d: 0-0-0 (+0.0u)
K.Williams u65.5 Rush Yds-145
1u
Tailing @The_Oddsmaker

Sean Koerner
Last 30d: 10-12-0 (-0.9u)
K.Williams u67.5 Rush Yds-115
1.15u
Gilles Gallant
Last 30d: 1-5-0 (-2.0u)
B.Corum Anytime TD Scorer Yes+1200
0.25u
TOUCHDOWN SHOW SPICY BET NO.1 🌶️SHOW IS 11:30AM ET FOR FULL ANALYSIS.

MJC Locks
Last 30d: 3-2-0 (+0.8u)
M.Stafford o0.5 Int-137
1.37u
⭐️ NFL Play of the Week

Firefighter Bets
Last 30d: 41-64-0 (-22.3u)
T.Reeder o6.5 Tackles + Ast+115
1.15u

Cam Is Money
Last 30d: 98-115-3 (-8.2u)
LA +6.5-110
0.91u

Collin Wilson
Last 30d: 0-0-0 (+0.0u)
LA +6.5-108
1u

Anders
Last 30d: 7-8-0 (-6.3u)
Under 43.5-110
1.1u

Moneyline Hacks
Last 30d: 75-77-3 (+10.4u)
M.Stafford o0.5 Rush Yds+115
1u

Brandon Anderson
Last 30d: 0-2-0 (-0.5u)
SF o24.5 Team Total+105
1u
Kitchen Sink week! TAN pod / best bets
Line slowly dropping with injury news. This has gone too far but get best line you can up to o26.5 as per pod

Markus Markets
Last 30d: 10-8-1 (+1.2u)
B.Aiyuk o64.5 Rec Yds-125
1u
Fliff

SpenceBets
Last 30d: 0-0-0 (+0.0u)
LA +7.5-115
0.43u

Prop Bet Guy
Last 30d: 0-0-0 (+0.0u)
J.Jennings o33.5 Rec Yds-110
1u
Over in 2/2 as is, and SF already with a lack of reliable targets with no Deebo or CMC.

Jim Sannes
Last 30d: 20-52-0 (-13.5u)
Over 43.5-115
0.87u
Tons of offensive injuries in this game, but the Rams' defense stinks and just lost another key piece. Don't need this game to go nuts to hit the over, so I'm cool with it despite the injuries.

Mitch Carl
Last 30d: 0-0-0 (+0.0u)
SF -7-115
1u
PRO Insights

49ers
SF Insights
- Featured Insight
The 49ers have run 18.0% offensive plays in the red zone this season -- T-7th-best in NFL; the Rams have allowed their opponent to run 20.0% of plays in the red zone this season -- 7th-worst in NFL.
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Rams
LA Insights
- Featured Insight
Rams QBs have a 112.1 passer rating in the fourth quarter this season -- 5th-best in NFL; the 49ers have allowed a passer rating of 105.1 in the 4th quarter this season -- 6th-worst in NFL.
TRY FOR FREE
49ers vs. Rams Previews & Analysis
49ers vs. Rams Props
Prop Projections
There are no prop projections found for the selected slate. Please check back later.
Prop Odds Comparison
Line Movement Tracker
49ers vs. Rams Public Betting Percentages
Betting Trends
- Rams are 4-1 in their last 5 games.
- Rams are 4-1 in their last 5 games against the spread
- Rams are 5-3 in their road games against the spread
- The totals have gone OVER in 2 of Rams' last 5 games
- The totals have gone OVER in 5 of Rams' 9 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Rams vs. 49ers Injury Updates

Rams Injuries

49ers Injuries
- Trevis GipsonLB
Gipson is out with ankle
Out
Team Stats
49ers vs. Rams Odds Comparison
Could not load odds
49ers at Rams Team Totals
MatchupOverUnder | ||
---|---|---|
![]() 49ers 0-1 | o25.5-108 | u25.5-112 |
![]() Rams 1-0 | o19.5-108 | u19.5-112 |