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49ers vs. Rams Odds & Betting Predictions - September 22, 2024

49ers at Rams

8:25 pm • FOX

San Francisco 49ers

3-4
24
24 - 27

Los Angeles Rams

2-4
27

49ers at Rams Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
49ers
3-4
-2.5
-6-108
o44.5-109
-264
Rams
2-4
u49
+6-112
u44.5-111
+215
location pinSunday 8:25 p.m.
September 22, 2024
SoFi StadiumInglewood
49ers vs. Rams Expert Picks
Bet What Happens Live!
Bet What Happens Live!
29d ago
Last 30d: 63-108-0 (-9.6u)
LA +7.5 (Live)-115
1u
Ryan Sura
Ryan Sura
29d ago
Last 30d: 100-118-1 (-13.0u)
LA +10.5 (Live)-125
1u
RocketPlays
RocketPlays
29d ago
Last 30d: 32-57-0 (+1.3u)
Under 44.5-106
1.06u
Top Shelf Action 🥃
Top Shelf Action 🥃
29d ago
Last 30d: 139-168-1 (-23.9u)
Under 22.5 (1H)-110
0.91u
#ProSystem ... 1H windy unders Overall: 380-278-120,58% (ROI:10%) Season:4-3-0,57% (ROI:6%)
Shady Biev
Shady Biev
29d ago
Last 30d: 159-158-3 (+21.8u)
K.Williams Anytime TD Scorer Yes-110
2u
Vegas Refund
Vegas Refund
29d ago
Last 30d: 30-42-1 (-16.2u)
LA +6.5-110
1u
Moneyline Hacks
Moneyline Hacks
29d ago
Last 30d: 121-95-2 (+61.8u)
M.Stafford o0.5 Rush Yds+115
2u
LA +6.5-110
0.91u
Top Shelf Action 🥃
Top Shelf Action 🥃
29d ago
Last 30d: 139-168-1 (-23.9u)
LA +3.5 (1H)-110
1u
#ProSystem ... 1H dog off bad loss Overall: 192-105-6,65% (ROI:25%) Season:0-0-0, 0% (ROI: 0%)
The Touchdown Show
The Touchdown Show
29d ago
Last 30d: 11-41-0 (+7.1u)
B.Corum Anytime TD Scorer Yes+1100
0.25u
@GDAWG5000
B.Aiyuk Anytime TD Scorer Yes+130
1u
@TheBMatt
Greg Matherne
Greg Matherne
29d ago
Last 30d: 26-44-1 (-15.1u)
Under 44.5-110
0.55u
JB Bets
JB Bets
29d ago
Last 30d: 61-70-0 (-5.0u)
J.Mason 90+ Rushing Yards Yes-125
1u
YBK Picks.com
29d ago
Last 30d: 47-46-0 (-4.9u)
LA +6.5-105
1.9u
Sean Zerillo
Sean Zerillo
29d ago
Last 30d: 130-173-5 (-12.9u)
Under 44.5-110
0.55u
Kyle Just Bets
Kyle Just Bets
29d ago
Last 30d: 27-21-0 (+5.1u)
J.Mason o89.5 Rush Yds-117
1u
Brian Matthews
Brian Matthews
29d ago
Last 30d: 7-17-0 (+5.0u)
B.Aiyuk Anytime TD Scorer Yes+120
1u
Mild pick for today’s TD show
Prop Bet Guy
Prop Bet Guy
29d ago
Last 30d: 79-69-0 (+0.4u)
C.Parkinson u14.5 Longest Reception-110
1u
Full write-up: https://www.actionnetwork.com/nfl/nfl-player-prop-picks-today-for-ej-speed-colby-parkinson
Brian Bitler
Brian Bitler
30d ago
Last 30d: 41-39-8 (+2.7u)
LA +6.5-110
2.73u
Top Shelf Action 🥃
Top Shelf Action 🥃
30d ago
Last 30d: 139-168-1 (-23.9u)
Under 44-108
1u
#ProSystem
Sandy Plashkes
Sandy Plashkes
30d ago
Last 30d: 116-115-2 (+8.3u)
LA +6.5-110
1u
Shady Biev
Shady Biev
30d ago
Last 30d: 159-158-3 (+21.8u)
LA +6.5-112
2u
Chad Millman
Chad Millman
30d ago
Last 30d: 20-24-0 (-3.3u)
K.Williams u65.5 Rush Yds-145
1u
Tailing @The_Oddsmaker
Collin Whitchurch
Collin Whitchurch
30d ago
Last 30d: 169-157-3 (-0.0u)
K.Williams u69.5 Rush Yds-135
2.03u
Sean Koerner
Sean Koerner
30d ago
Last 30d: 25-32-0 (-11.3u)
K.Williams u67.5 Rush Yds-115
1.15u
Gilles Gallant
Gilles Gallant
30d ago
Last 30d: 35-83-0 (-1.2u)
B.Corum Anytime TD Scorer Yes+1200
0.25u
TOUCHDOWN SHOW SPICY BET NO.1 🌶️SHOW IS 11:30AM ET FOR FULL ANALYSIS.
MJC Locks
MJC Locks
31d ago
Last 30d: 16-13-0 (+3.6u)
M.Stafford o0.5 Int-137
1.37u
⭐️ NFL Play of the Week
Firefighter Bets
Firefighter Bets
31d ago
Last 30d: 69-73-0 (-11.0u)
T.Reeder o6.5 Tackles + Ast+115
1.15u
Collin Wilson
Collin Wilson
31d ago
Last 30d: 67-70-3 (-10.8u)
LA +6.5-108
1u
Moneyline Hacks
Moneyline Hacks
32d ago
Last 30d: 121-95-2 (+61.8u)
M.Stafford o0.5 Rush Yds+115
1u
Brandon Anderson
Brandon Anderson
32d ago
Last 30d: 41-48-0 (+15.3u)
SF o24.5 Team Total+105
1u
Kitchen Sink week! TAN pod / best bets Line slowly dropping with injury news. This has gone too far but get best line you can up to o26.5 as per pod
Markus Markets
Markus Markets
32d ago
Last 30d: 40-47-0 (+7.6u)
B.Aiyuk o64.5 Rec Yds-125
1u
Fliff
Prop Bet Guy
Prop Bet Guy
33d ago
Last 30d: 79-69-0 (+0.4u)
J.Jennings o33.5 Rec Yds-110
1u
Over in 2/2 as is, and SF already with a lack of reliable targets with no Deebo or CMC.
Jim Sannes
Jim Sannes
34d ago
Last 30d: 8-28-0 (-13.9u)
Over 43.5-115
0.87u
Tons of offensive injuries in this game, but the Rams' defense stinks and just lost another key piece. Don't need this game to go nuts to hit the over, so I'm cool with it despite the injuries.
Mitch Carl
Mitch Carl
35d ago
Last 30d: 23-15-3 (+5.9u)
SF -7-115
1u

PRO Insights

49ers logo

49ers

SF Insights
  • Featured Insight
    49ers logoThe 49ers have run 18.0% offensive plays in the red zone this season -- T-7th-best in NFL; the Rams have allowed their opponent to run 20.0% of plays in the red zone this season -- 7th-worst in NFL.
TRY FOR FREE
Rams logo

Rams

LA Insights
  • Featured Insight
    Rams logoRams QBs have a 112.1 passer rating in the fourth quarter this season -- 5th-best in NFL; the 49ers have allowed a passer rating of 105.1 in the 4th quarter this season -- 6th-worst in NFL.
TRY FOR FREE

49ers vs. Rams Previews & Analysis

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    2 Grimy TD Picks for the Injury-Riddled Game

    Action AI•
    Sep 22, 2024 UTC
  • How to Live Bet Cowboys vs Ravens & Lions vs Cardinals! | NFL Picks & Props | Bet What Happens Live article feature image

    How to Live Bet Cowboys vs Ravens & Lions vs Cardinals! | NFL Picks & Props | Bet What Happens Live

    Grant Neiffer•
    Sep 22, 2024 UTC
  • 49ers vs. Rams Prediction: Back the San Francisco Offense article feature image

    49ers vs. Rams Prediction: Back the San Francisco Offense

    Action Network Staff•
    Sep 22, 2024 UTC
  • NFL 'Blowout' System Spots 3 Picks Sunday article feature image

    NFL 'Blowout' System Spots 3 Picks Sunday

    Alex Kolodziej•
    Sep 22, 2024 UTC
See more NFL Coverage Right Arrow

49ers vs. Rams Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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49ers vs. Rams Public Betting Percentages

49ers

Public

Home Logo

Rams

69%

Bets%

31%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Rams are 1-4 in their last 5 games.
  • Rams are 1-4 in their last 5 games against the spread
  • Rams are 0-3 in their road games against the spread
  • The totals have gone OVER in 3 of Rams' last 5 games
  • The totals have gone OVER in 1 of Rams' 3 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Rams		1-51-20-30-11-3
49ers		3-42-21-23-4N/A

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Rams		3-31-22-10-12-2
49ers		4-32-22-14-3N/A

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Rams		2-4N/AN/A1-01-3
49ers		3-4N/AN/A3-4N/A

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 15th@ARIL 10-41+1 LO 47ARI -110
Sep 9th@DETL 20-26+5.5 LU 53.5DET +195
Aug 24th@HOUL 15-17+4 WU 33.5HOU +170
Aug 17th@LACW 13-9+3.5 WU 32.5LA +150
Aug 11thDALW 13-12+5.5 WU 35.5LA +195

Rams vs. 49ers Injury Updates

Rams Injuries

  • Jimmy Garoppolo
    QB

    Garoppolo is out with suspension

    Out

  • Tyler Higbee
    TE

    Higbee is out with knee

    Out

  • Cooper Kupp
    WR

    Kupp is questionable with knee

    Questionable

  • Puka Nacua
    WR

    Nacua is out with knee

    Out

49ers Injuries

  • Christian McCaffrey
    RB

    Christian McCaffrey to be placed on injured reserve. Will miss at least 4 weeks.

    Out

  • Matthew Wright
    K

    Wright is out with shoulder

    Out

  • Kevin Givens
    DE

    Givens is questionable with groin

    Questionable

  • Jauan Jennings
    WR

    Jennings is out with hip

    Out

  • Darrell Luter
    CB

    Luter is questionable with pelvis

    Questionable

  • Ricky Pearsall
    WR

    Pearsall is questionable with chest

    Questionable

See more NFL Injuries Right Arrow
Team Stats

Total

425
Total Yards
296
65
Total Plays
55
6.5
Yards Per Play
5.4

Passing

292
YDS
221
22/30
Comps/Atts
16/26
9.29
YPA
6.828
3/0
TDs/INTs
1/0
1/4
Sacks/Yards
3/23

Rushing

137
Rush Yards
98
34
Attempts
26
4.029
YPC
3.769
0
TDs
2

Turnovers

1
Fumbles Lost
0
0
Interceptions
0

Efficiency

2/3 66.67%
Redzone
3/5 60%
6/11 0%
3rd Down
5/12 0%
1/1 0%
4th Down
2/2 0%

First Downs

25
Total
19
13
Pass
8
8
Rush
8
4
Penalty
3

Misc

7/111
Penalties/Yards
8/75
33:27
Possession
26:33

49ers vs. Rams Odds Comparison

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49ers at Rams Team Totals

MatchupOverUnder
49ers
3-4
o25.5-108
u25.5-112
Rams
2-4
o19.5-108
u19.5-112