49ers vs. Bills Odds & Betting Predictions - December 2, 2024

49ers at Bills

1:20 am • NBC
10 - 35

49ers at Bills Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
49ers
6-9
-2
+6.5-110
o45.5-110
+267
Bills
12-3
u47
-6.5-110
u45.5-110
-332
location pinMonday 1:20 a.m.
December 02, 2024
Highmark StadiumOrchard Park
49ers vs. Bills Expert Picks
Markus Markets
Markus Markets
25d ago
Last 30d: 67-76-1 (+6.9u)
R.Davis o30.5 Rush Yds (Live)-120
0.83u
Fliff
Collin Wilson
Collin Wilson
25d ago
Last 30d: 67-75-4 (-34.1u)
Under 47 (Live)-102
1u
Jeremiah Rose
Jeremiah Rose
25d ago
Last 30d: 45-35-0 (+10.1u)
J.Mason Anytime TD Scorer Yes (Live)+140
0.25u
Boyd
C.McCaffrey Anytime TD Scorer Yes (Live)+100
0.25u
Boyd
Gamblers Dream
Gamblers Dream
25d ago
Last 30d: 24-26-0 (+16.6u)
C.McCaffrey Anytime TD Scorer Yes (Live)-105
3u
He has great feet tonight - running very well on snow. He is due. I am pressing it.
Jeremiah Rose
Jeremiah Rose
25d ago
Last 30d: 45-35-0 (+10.1u)
J.Allen Anytime TD Scorer Yes (Live)+130
0.33u
Boyd
Stuck 🚨
Stuck 🚨
25d ago
Last 30d: 63-55-2 (+1.0u)
Over 44.5 (Live)-110
0.18u
Snowver alert
Boomer Betz
Boomer Betz
25d ago
Last 30d: 138-130-8 (+18.3u)
SF +260
1u
SF +6.5-110
3u
Booger
SF +6.5-110
0.3u
Chris Raybon
Chris Raybon
25d ago
Last 30d: 13-18-0 (-5.5u)
Under 45.5-110
0.91u
Sandy  Plashkes
Sandy Plashkes
25d ago
Last 30d: 112-124-3 (-10.0u)
SF o20 Team Total+100
1u
Collin Wilson
Collin Wilson
25d ago
Last 30d: 67-75-4 (-34.1u)
SF +7-120
1.2u
Ryan Sura
Ryan Sura
25d ago
Last 30d: 100-108-6 (-13.1u)
J.Allen Anytime TD Scorer Yes+115
1.15u
Dale Tanhardt
Dale Tanhardt
25d ago
Last 30d: 6-25-0 (-2.7u)
R.Davis Anytime TD Scorer Yes+650
5.2u
T.Johnson Anytime TD Scorer Yes+750
0.6u
K.Juszczyk Anytime TD Scorer Yes+1400
0.3u
Sir Lockselot
Sir Lockselot
25d ago
Last 30d: 35-68-0 (-22.0u)
SF +280
1u
ProphetX Line 🔑 49ers ML +280 (ProphetX) 1u This is just too good of value to pass up on. I know the bills have been awesome and the 49ers have been trash but this just seems like an NFL weird game that the Niners win. They need this W BAD and the Bills are due for an L. Worth a sprinkle
Sandy  Plashkes
Sandy Plashkes
25d ago
Last 30d: 112-124-3 (-10.0u)
SF +6.5-110
1.1u
Collin Wilson
Collin Wilson
25d ago
Last 30d: 67-75-4 (-34.1u)
Over 44.5-111
1u
Player Prop Savant
Player Prop Savant
25d ago
Last 30d: 35-35-0 (-6.3u)
J.Allen o262.5 Pass + Rush Yds-115
1.15u
Jeremiah Rose
Jeremiah Rose
25d ago
Last 30d: 45-35-0 (+10.1u)
BUF -6-120
0.5u
The Propfessor
The Propfessor
25d ago
Last 30d: 51-34-0 (+13.3u)
J.Cook o14.5 Rush Att-109
1.09u
YBK Picks.com
25d ago
Last 30d: 44-47-2 (-11.4u)
Under 44.5-105
2u
Sean Koerner
Sean Koerner
25d ago
Last 30d: 33-21-1 (+9.6u)
R.Pearsall o17.5 Rec Yds-110
1.1u
Shady Biev
Shady Biev
25d ago
Last 30d: 188-216-7 (+9.6u)
C.McCaffrey Anytime TD Scorer Yes-115
2.88u
C.McCaffrey Anytime TD Scorer Yes-115
2.88u
Billy Ward
Billy Ward
25d ago
Last 30d: 13-16-1 (-0.8u)
Over 44.5-110
1u
Brian Bitler
Brian Bitler
25d ago
Last 30d: 88-77-2 (+23.7u)
SF +6.5-110
3u
Allan Lem
Allan Lem
25d ago
Last 30d: 39-23-2 (+6.7u)
B.Purdy u33.5 Longest Completion-110
0.25u
Tailing @PropBomb
Prop Bomb 🏝
Prop Bomb 🏝
25d ago
Last 30d: 10-6-0 (+3.1u)
B.Purdy u33.5 Longest Completion-110
1u
This has been a system play all season. A trend that continues to hold strong as more data keep collecting - something we’ve played three times with QBs vs. the Bills. Their secondary is responsible for holding nine of the last 11 total QBs to go under this prop resulting in two out of 373 of their total completions to have gone for more than 34+ recording yards. And one of those coming from a hail-mary from Aaron Rodgers at halftime to Allen Lazard for zero seconds left, According to Fantasy Points, their high rates of zone (9th) and two-safety coverage (4th), are taking away big plays, and forcing QBs to have a 8.0% deep-throw% considering of 20+ air yards (2nd lowest), 6.8 aDOT (lowest), and a 6.69 yards/attempt (7th-lowest). Rasul Douglas and Christian Benford, who both rank bottom-12 in fantasy points per route run + pass-rushers Greg Rousseau/Von Miller are responsible why. Past deep-threats who couldn’t do it include Xavier Worthy, Travis Kelce, Calvin Ridley, Tyreek Hill x2, Rashod Bateman, Marvin Harrison Jr to name a few. As for Brock Purdy tonight: He was listed as questionable all week dealing with shoulder soreness, and is set to make his return vs. the Bills on Sunday Night. This will be the first time he meets up vs. this team but the dynamics will be very different considering it’s set to be a “Snow Game” with weather likely playing a role this game. Left Tackle Trent Williams is set to miss his second game in a row which further hurts pass protection, and with CMC back healthy, I’m backing the Bills defense to shutdown a big play even knowing SF’s weapons YAC ability to keep this trend going strong. #PlayerProps
Kyle Just Bets
Kyle Just Bets
25d ago
Last 30d: 28-24-0 (+1.9u)
C.McCaffrey o86.5 Rush + Rec Yds-115
0.85u
JB Bets
JB Bets
25d ago
Last 30d: 33-13-0 (+14.1u)
C.McCaffrey o30.5 Rec Yds-113
1u
GO CHECK OUT MY 2 LOTTO PARLAYS IN VIP, LINKS ARE IN MY BIO! 10 LIKES AND ILL POST ANOTHER FREE PLAY Bills are allowing the most Rec yards to RBs this year (50.73) #PropBet
Matt Moore
Matt Moore
25d ago
Last 30d: 95-110-2 (+0.1u)
BUF -6.5-110
0.5u
MoneyLineWixted
MoneyLineWixted
25d ago
Last 30d: 36-39-3 (-10.1u)
J.Cook o62.5 Rush Yds-120
1u
Gilles Gallant
Gilles Gallant
25d ago
Last 30d: 36-74-0 (+0.3u)
J.Allen Anytime TD Scorer Yes+130
1.3u
Mjaybrod
Mjaybrod
25d ago
Last 30d: 154-146-0 (+10.9u)
J.Cook o84.5 Rush + Rec Yds-110
0.91u
Cooking with bacon grease
MoneyLineWixted
MoneyLineWixted
25d ago
Last 30d: 36-39-3 (-10.1u)
BUF -5.5-122
2u
Bet365
Shady Biev
Shady Biev
25d ago
Last 30d: 188-216-7 (+9.6u)
SF +6.5-112
2.24u
SF +240
1u
Moneyline Hacks
Moneyline Hacks
25d ago
Last 30d: 46-46-1 (+8.4u)
Over 44.5-110
0.91u
All Free analysis & VIP Picks can be found on our Discord. Link: https://discord.gg/A8v49URQaG ⬇️All Access VIP Picks (Copy and paste link)⬇️ https://dubclub.win/r/MoneylineHacks/
Jeremiah Rose
Jeremiah Rose
25d ago
Last 30d: 45-35-0 (+10.1u)
D.Knox o2.5 Recs-118
1u
Boyd
Gilles Gallant
Gilles Gallant
25d ago
Last 30d: 36-74-0 (+0.3u)
J.Jennings Anytime TD Scorer Yes+350
0.5u
G.Kittle Anytime TD Scorer Yes+275
0.6u
Grant Neiffer
Grant Neiffer
26d ago
Last 30d: 44-42-4 (-3.7u)
C.McCaffrey o61.5 Rush Yds-110
1.1u
Jay Money
Jay Money
27d ago
Last 30d: 24-18-3 (+1.6u)
SF +7-110
1.1u
Brandon Anderson
Brandon Anderson
27d ago
Last 30d: 30-67-0 (-12.4u)
BUF -7-107
0.93u
Buying out of our SF +7 Hot Read position. Bosa, Trent still not practicing at all look unlikely, Purdy still a ??, possible lake effect snow game, just too much doesn't feel right and we can get out with just a ~0.08u cost so I don't need it. I'll leave the 0.5u ML to ride and hope for the best.
Picks  Office
Picks Office
27d ago
Last 30d: 116-95-5 (+13.6u)
Under 44.5-105
1u
Read full writeup on X: https://x.com/PicksOffice San Francisco's offense relies heavily on Brock Purdy, and his potential absence raises concerns, especially with their red zone struggles against Buffalo's strong defense. Buffalo’s balanced attack faces a disciplined 49ers defense that limits big plays. Both teams thrive defensively, creating a matchup likely defined by methodical drives and limited scoring opportunities.
Brandon Anderson
Brandon Anderson
32d ago
Last 30d: 30-67-0 (-12.4u)
SF +7-110
1u
Week 13 Hot Read 🔥
SF +260
0.5u
Week 13 Hot Read 🔥 https://www.actionnetwork.com/nfl/nfl-week-13-picks-predictions-our-experts-sunday-night-hot-reads?utm_source=twitter&utm_medium=social&utm_campaign=brandonanderson

49ers vs. Bills Previews & Analysis

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49ers vs. Bills Props

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49ers vs. Bills Public Betting Percentages

39%

Bets%

61%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Bills
9-64-35-37-42-2
49ers
5-104-41-65-80-2

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Bills
9-65-24-48-31-3
49ers
8-74-44-37-61-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Bills
12-3N/AN/A10-12-2
49ers
6-9N/AN/A6-70-2

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 17thKCW 30-21-2.5 WO 47BUF -150
Nov 10th@INDW 30-20-4.5 WO 46.5BUF -230
Nov 3rdMIAW 30-27-6.5 LO 49BUF -298
Oct 27th@SEAW 31-10-3 WU 45.5BUF -165
Oct 20thTENW 34-10-9.5 WO 41BUF -550

49ers vs. Bills Injury Updates

49ers Injuries

  • Jon Feliciano
    OL

    Feliciano is questionable with knee

    Questionable

  • Trent Williams
    T

    Williams is out with ankle

    Out

  • Christian McCaffrey
    RB

    McCaffrey is out with knee

    Out

  • George Odum
    S

    Odum is out with knee

    Out

  • Dre Greenlaw
    LB

    Greenlaw is questionable with achilles

    Questionable

  • Nick Bosa
    DE

    Bosa is questionable with hip

    Questionable

  • Kevin Givens
    DE

    Givens is questionable with groin

    Questionable

  • Mitch Wishnowsky
    P

    Wishnowsky is out with back

    Out

  • Brandon Aiyuk
    WR

    Aiyuk is out with leg

    Out

  • Ben Bartch
    OL

    Bartch is out with ankle

    Out

  • Khalil Davis
    DT

    Davis is questionable with knee

    Questionable

  • Jordan Mason
    RB

    Mason is out with ankle

    Out

  • Robert Beal
    DE

    Beal is questionable with ankle

    Questionable

  • Darrell Luter
    CB

    Luter is doubtful with pelvis

    Doubtful

  • Renardo Green
    DB

    Green is questionable with neck

    Questionable

  • Isaac Guerendo
    RB

    Guerendo is questionable with hamstring

    Questionable

  • Tatum Bethune
    LB

    Bethune is out with knee

    Out

Bills Injuries

  • Jordan Phillips
    DT

    Phillips is out with wrist

    Out

  • Curtis Samuel
    WR

    Samuel is questionable with ribs

    Questionable

  • Rasul Douglas
    CB

    Douglas is questionable with knee

    Questionable

  • Matt Milano
    LB

    Milano is questionable with biceps

    Questionable

  • Taylor Rapp
    S

    Rapp is questionable with neck

    Questionable

  • Casey Toohill
    DE

    Toohill is questionable with ribs

    Questionable

  • Damar Hamlin
    S

    Hamlin is questionable with back

    Questionable

  • Baylon Spector
    LB

    Spector is questionable with calf

    Questionable

  • Dorian Williams
    LB

    Williams is questionable with elbow

    Questionable

  • Tylan Grable
    OL

    Grable is out with groin

    Out

Team Stats
239
Total Yards
372
47
Total Plays
56
5.1
Yards Per Play
6.6

Passing

94
YDS
152
11/18
Comps/Atts
14/18
4.3
YPA
8.444
0/0
TDs/INTs
2/0
2/8
Sacks/Yards
0/0

Rushing

153
Rush Yards
220
27
Attempts
38
5.667
YPC
5.789
1
TDs
3

Turnovers

3
Fumbles Lost
0
0
Interceptions
0

Efficiency

1/3 33.33%
Redzone
4/4 100%
3/10 0%
3rd Down
6/12 0%
1/1 0%
4th Down
1/1 0%

First Downs

15
Total
20
4
Pass
7
10
Rush
12
1
Penalty
1
2/10
Penalties/Yards
5/35
26:33
Possession
33:27

49ers vs. Bills Odds Comparison

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49ers at Bills Team Totals

MatchupOverUnder
49ers
6-9
o19.5-108
u19.5-112
Bills
12-3
o26.5-122
u26.5+102