49ers vs. Bills Odds & Betting Predictions - December 2, 2024
49ers at Bills
1:20 am • NBC49ers at Bills Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
---|---|---|---|---|
![]() 49ers 0-1 | -2 | +6.5-110 | o45.5-110 | +267 |
![]() Bills 0-1 | u47 | -6.5-110 | u45.5-110 | -332 |

Highmark StadiumOrchard Park
49ers vs. Bills Expert Picks

Markus Markets
Last 30d: 10-8-1 (+1.2u)
R.Davis o30.5 Rush Yds (Live)-120
0.83u
Fliff

Collin Wilson
Last 30d: 0-0-0 (+0.0u)
Under 47 (Live)-102
1u

Jeremiah Rose
Last 30d: 9-18-0 (+0.7u)
J.Mason Anytime TD Scorer Yes (Live)+140
0.25u
Boyd
C.McCaffrey Anytime TD Scorer Yes (Live)+100
0.25u
Boyd

Gamblers Dream
Last 30d: 8-10-0 (+34.5u)
C.McCaffrey Anytime TD Scorer Yes (Live)-105
3u
He has great feet tonight - running very well on snow.
He is due. I am pressing it.

Jeremiah Rose
Last 30d: 9-18-0 (+0.7u)
J.Allen Anytime TD Scorer Yes (Live)+130
0.33u
Boyd

Stuck 🚨
Last 30d: 1-1-0 (+0.0u)
Over 44.5 (Live)-110
0.18u
Snowver alert

YBB SportsData
Last 30d: 1-5-0 (-4.2u)
Under 45.5 (Live)-115
1u

JC Cornell
Last 30d: 1-0-0 (+5.3u)
J.Cook o65.5 Rush Yds (Live)-120
1u
J.Allen o33.5 Rush Yds (Live)-117
1.17u
BUF -6.5 (Live)-120
1u

Boomer Betz
Last 30d: 194-184-3 (+16.0u)
SF +6.5-110
3u
Booger
SF +6.5-110
0.3u
SF +260
1u

The Degenerate
Last 30d: 0-0-0 (+0.0u)
C.McCaffrey o102.5 Rush + Rec Yds-115
1u

Chris Raybon
Last 30d: 1-0-0 (+0.9u)
Under 45.5-110
0.91u

Sandy Plashkes
Last 30d: 54-69-0 (-3.8u)
SF o20 Team Total+100
1u

Collin Wilson
Last 30d: 0-0-0 (+0.0u)
SF +7-120
1.2u

The Degenerate
Last 30d: 0-0-0 (+0.0u)
J.Cook First Touchdown Scorer Yes+500
1u
Collab with @Steakfriend123

Ryan Sura
Last 30d: 33-47-3 (+19.4u)
J.Allen Anytime TD Scorer Yes+115
1.15u

STL ELITE
Last 30d: 6-4-0 (+8.9u)
C.McCaffrey o63.5 Rush Yds-120
2.4u
SF +270
1.5u

Dale Tanhardt
Last 30d: 3-16-0 (+1.8u)
R.Davis Anytime TD Scorer Yes+650
5.2u
T.Johnson Anytime TD Scorer Yes+750
0.6u
K.Juszczyk Anytime TD Scorer Yes+1400
0.3u

Sir Lockselot
Last 30d: 31-59-0 (-26.4u)
SF +280
1u
ProphetX Line
🔑 49ers ML +280 (ProphetX) 1u
This is just too good of value to pass up on. I know the bills have been awesome and the 49ers have been trash but this just seems like an NFL weird game that the Niners win. They need this W BAD and the Bills are due for an L. Worth a sprinkle

Sandy Plashkes
Last 30d: 54-69-0 (-3.8u)
SF +6.5-110
1.1u

Collin Wilson
Last 30d: 0-0-0 (+0.0u)
Over 44.5-111
1u

Player Prop Savant
Last 30d: 20-28-1 (-8.4u)
J.Allen o262.5 Pass + Rush Yds-115
1.15u

Cam Is Money
Last 30d: 98-115-3 (-8.2u)
C.McCaffrey o102.5 Rush + Rec Yds-115
1u
C.McCaffrey Anytime TD Scorer Yes-130
1u

Jeremiah Rose
Last 30d: 9-18-0 (+0.7u)
BUF -6-120
0.5u

The Propfessor
Last 30d: 27-38-0 (+12.4u)
J.Cook o14.5 Rush Att-109
1.09u

Greg DiNardo
Last 30d: 0-0-0 (+0.0u)
Over 44.5-114
1u
YBK Picks.com
Last 30d: 9-20-2 (-21.9u)
Under 44.5-105
2u

Sean Koerner
Last 30d: 10-12-0 (-0.9u)
R.Pearsall o17.5 Rec Yds-110
1.1u

Shady Biev
Last 30d: 0-1-0 (-3.0u)
C.McCaffrey Anytime TD Scorer Yes-115
2.88u
C.McCaffrey Anytime TD Scorer Yes-115
2.88u

Billy Ward
Last 30d: 14-17-0 (-3.4u)
Over 44.5-110
1u

STL ELITE
Last 30d: 6-4-0 (+8.9u)
SF +12-120
2.4u
*** 6pt teaser with Panthers +12 ***

Brian Bitler
Last 30d: 70-72-1 (-3.5u)
SF +6.5-110
3u

Steak Friend
Last 30d: 0-0-0 (+0.0u)
BUF -6-110
1u

Allan Lem
Last 30d: 46-48-1 (-2.8u)
B.Purdy u33.5 Longest Completion-110
0.25u
Tailing @PropBomb

Prop Bomb 🏝
Last 30d: 1-0-0 (+1.2u)
B.Purdy u33.5 Longest Completion-110
1u
This has been a system play all season. A trend that continues to hold strong as more data keep collecting - something we’ve played three times with QBs vs. the Bills. Their secondary is responsible for holding nine of the last 11 total QBs to go under this prop resulting in two out of 373 of their total completions to have gone for more than 34+ recording yards. And one of those coming from a hail-mary from Aaron Rodgers at halftime to Allen Lazard for zero seconds left,
According to Fantasy Points, their high rates of zone (9th) and two-safety coverage (4th), are taking away big plays, and forcing QBs to have a 8.0% deep-throw% considering of 20+ air yards (2nd lowest), 6.8 aDOT (lowest), and a 6.69 yards/attempt (7th-lowest). Rasul Douglas and Christian Benford, who both rank bottom-12 in fantasy points per route run + pass-rushers Greg Rousseau/Von Miller are responsible why. Past deep-threats who couldn’t do it include Xavier Worthy, Travis Kelce, Calvin Ridley, Tyreek Hill x2, Rashod Bateman, Marvin Harrison Jr to name a few.
As for Brock Purdy tonight: He was listed as questionable all week dealing with shoulder soreness, and is set to make his return vs. the Bills on Sunday Night. This will be the first time he meets up vs. this team but the dynamics will be very different considering it’s set to be a “Snow Game” with weather likely playing a role this game. Left Tackle Trent Williams is set to miss his second game in a row which further hurts pass protection, and with CMC back healthy, I’m backing the Bills defense to shutdown a big play even knowing SF’s weapons YAC ability to keep this trend going strong. #PlayerProps

Kyle Just Bets
Last 30d: 0-0-0 (+0.0u)
C.McCaffrey o86.5 Rush + Rec Yds-115
0.85u

JB Bets
Last 30d: 0-0-0 (+0.0u)
C.McCaffrey o30.5 Rec Yds-113
1u
GO CHECK OUT MY 2 LOTTO PARLAYS IN VIP, LINKS ARE IN MY BIO! 10 LIKES AND ILL POST ANOTHER FREE PLAY
Bills are allowing the most Rec yards to RBs this year (50.73)
#PropBet

Matt Moore
Last 30d: 0-0-0 (+0.0u)
BUF -6.5-110
0.5u

MoneyLineWixted
Last 30d: 3-2-0 (+1.0u)
J.Cook o62.5 Rush Yds-120
1u
Gilles Gallant
Last 30d: 1-5-0 (-2.0u)
J.Allen Anytime TD Scorer Yes+130
1.3u

Mjaybrod
Last 30d: 1-1-0 (-0.0u)
J.Cook o84.5 Rush + Rec Yds-110
0.91u
Cooking with bacon grease

MoneyLineWixted
Last 30d: 3-2-0 (+1.0u)
BUF -5.5-122
2u
Bet365

Shady Biev
Last 30d: 0-1-0 (-3.0u)
SF +6.5-112
2.24u
SF +240
1u

Moneyline Hacks
Last 30d: 75-77-3 (+10.4u)
Over 44.5-110
0.91u
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Jeremiah Rose
Last 30d: 9-18-0 (+0.7u)
D.Knox o2.5 Recs-118
1u
Boyd
Gilles Gallant
Last 30d: 1-5-0 (-2.0u)
J.Jennings Anytime TD Scorer Yes+350
0.5u
G.Kittle Anytime TD Scorer Yes+275
0.6u

Steak Friend
Last 30d: 0-0-0 (+0.0u)
Over 44-110
1u

Cam Is Money
Last 30d: 98-115-3 (-8.2u)
C.McCaffrey o32.5 Rec Yds-115
1u
C.McCaffrey o4.5 Recs+110
1u

Grant Neiffer
Last 30d: 27-79-2 (+16.6u)
C.McCaffrey o61.5 Rush Yds-110
1.1u

Jay Money
Last 30d: 0-1-0 (-1.1u)
SF +7-110
1.1u

Brandon Anderson
Last 30d: 0-2-0 (-0.5u)
BUF -7-107
0.93u
Buying out of our SF +7 Hot Read position. Bosa, Trent still not practicing at all look unlikely, Purdy still a ??, possible lake effect snow game, just too much doesn't feel right and we can get out with just a ~0.08u cost so I don't need it. I'll leave the 0.5u ML to ride and hope for the best.

Picks Office
Last 30d: 74-73-1 (+8.1u)
Under 44.5-105
1u
Read full writeup on X: https://x.com/PicksOffice
San Francisco's offense relies heavily on Brock Purdy, and his potential absence raises concerns, especially with their red zone struggles against Buffalo's strong defense. Buffalo’s balanced attack faces a disciplined 49ers defense that limits big plays. Both teams thrive defensively, creating a matchup likely defined by methodical drives and limited scoring opportunities.

Brandon Anderson
Last 30d: 0-2-0 (-0.5u)
SF +7-110
1u
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Raybon's 49ers vs. Bills Prediction for SNF
49ers vs. Bills Props
Prop Projections
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Prop Odds Comparison
Line Movement Tracker
49ers vs. Bills Public Betting Percentages
Betting Trends
- Bills are 4-1 in their last 5 games.
- Bills are 4-1 in their last 5 games against the spread
- Bills are 5-4 in their road games against the spread
- The totals have gone OVER in 2 of Bills' last 5 games
- The totals have gone OVER in 6 of Bills' 8 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
49ers vs. Bills Injury Updates

49ers Injuries
- Trevis GipsonLB
Gipson is out with ankle
Out

Bills Injuries
Team Stats
49ers vs. Bills Odds Comparison
Could not load odds
49ers at Bills Team Totals
MatchupOverUnder | ||
---|---|---|
![]() 49ers 0-1 | o19.5-108 | u19.5-112 |
![]() Bills 0-1 | o26.5-122 | u26.5+102 |