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49ers vs. Bills Odds & Betting Predictions - December 2, 2024

49ers at Bills

1:20 am • NBC
Stream Live on SiriusXM - Free 3 Month Offer

San Francisco 49ers

5-5
@

Buffalo Bills

9-2

49ers at Bills Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
49ers
5-5
-2
+3+100
o47.5-110
+140
Bills
9-2
u47
-3-120
u47.5-110
-166
location pinMonday 1:20 a.m.
December 02, 2024
Highmark StadiumOrchard Park

49ers vs. Bills Props

Prop Projections

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49ers vs. Bills Public Betting Percentages

49ers

Public

Home Logo

Bills

60%

Bets%

40%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Bills are 4-1 in their last 5 games.
  • Bills are 4-1 in their last 5 games against the spread
  • Bills are 4-2 in their road games against the spread
  • The totals have gone OVER in 2 of Bills' last 5 games
  • The totals have gone OVER in 5 of Bills' 5 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Bills		7-43-24-26-21-2
49ers		4-63-31-34-6N/A

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Bills		7-45-02-47-10-3
49ers		5-53-32-25-5N/A

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Bills		9-2N/AN/A8-01-2
49ers		5-5N/AN/A5-5N/A

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Nov 17thKCW 30-21-2.5 WO 47BUF -150
Nov 10th@INDW 30-20-4.5 WO 46.5BUF -230
Nov 3rdMIAW 30-27-6.5 LO 49BUF -298
Oct 27th@SEAW 31-10-3 WU 45.5BUF -165
Oct 20thTENW 34-10-9.5 WO 41BUF -550

49ers vs. Bills Injury Updates

49ers Injuries

  • Jon Feliciano
    OL

    Feliciano is questionable with knee

    Questionable

  • Trent Williams
    T

    Williams is questionable with ankle

    Questionable

  • Charvarius Ward
    CB

    Ward is out with personal

    Out

  • Nick Bosa
    DE

    Bosa is questionable with hip

    Questionable

  • Kevin Givens
    DE

    Givens is out with groin

    Out

  • Mitch Wishnowsky
    P

    Wishnowsky is out with back

    Out

  • Brandon Aiyuk
    WR

    Aiyuk is out with leg

    Out

  • Yetur Gross-Matos
    DE

    Gross-Matos is questionable with knee

    Questionable

  • Aaron Banks
    OL

    Banks is questionable with thigh

    Questionable

  • Darrell Luter
    CB

    Luter is doubtful with pelvis

    Doubtful

Bills Injuries

  • Jordan Phillips
    DT

    Phillips is out with wrist

    Out

  • Amari Cooper
    WR

    Cooper is questionable with wrist

    Questionable

  • Matt Milano
    LB

    Milano is out with biceps

    Out

  • Spencer Brown
    T

    Brown is questionable with ankle

    Questionable

  • Baylon Spector
    LB

    Spector is questionable with calf

    Questionable

  • Dalton Kincaid
    TE

    Kincaid is out with knee

    Out

  • Keon Coleman
    WR

    Coleman is out with wrist

    Out

  • DeWayne Carter
    DT

    Carter is out with wrist

    Out

See more NFL Injuries Right Arrow
Player Stats
  • passing yards
    Josh Allen logo
    Josh Allen
    2543
    pyds
  • passing touchdowns
    Josh Allen logo
    Josh Allen
    18
    ptd
  • rushing yards
    James Cook logo
    James Cook
    596
    ryds
  • rushing touchdowns
    James Cook logo
    James Cook
    10
    rtd
Depth Charts
Right Arrow
Starter2ND3RD4TH
QBJosh AllenMitchell Trubisky
RBJames CookRay DavisTy JohnsonFrank Gore
WRKhalil ShakirKJ Hamler
TEDalton KincaidDawson KnoxQuintin MorrisZach Davidson
LTDion DawkinsRyan Van DemarkTravis Clayton
LGDavid EdwardsMike Edwards
CConnor McGovernSedrick Van Pran-GrangerWill Clapp
RGO'Cyrus TorrenceAlec Anderson
RTSpencer BrownTylan GrableRichard Gouraige
LDEGreg RousseauDawuane SmootJavon SolomonKameron Cline
RDEA.J. EpenesaVon MillerJavon SolomonCasey Toohill
WLBMatt MilanoDorian WilliamsEdefuan UlofoshioJoe Andreessen
MLBTerrel BernardBaylon SpectorNicholas Morrow
LCBChristian BenfordKaiir Elam
SSTaylor Rapp
FSDamar HamlinCole BishopKareem Jackson
RCBRasul DouglasJa'Marcus Ingram
PSam Martin
HSam Martin
PRKJ HamlerDaequan Hardy
KRKJ HamlerDaequan HardyTy Johnson
LSReid Ferguson
FBReggie Gilliam
RWRCurtis SamuelTyrell Shavers
NBTaron JohnsonCam LewisDaequan HardyTe'Cory Couch
NTDaQuan JonesAustin JohnsonEli Ankou
DTEd OliverDeWayne CarterBranson Deen
LWRKeon ColemanMack HollinsDeon Cain
KTyler Bass
Team Stats

Passing

2511
YDS
2487
202/306
Comps/Atts
219/342
8.539
YPA
7.45
13/8
TDs/INTs
18/5
21/102
Sacks/Yards
13/61

Rushing

1478
Rush Yards
1311
297
Attempts
307
4.976
YPC
4.27
10
TDs
18

Turnovers

Fumbles Lost
8
Interceptions
5

Efficiency

20/41 48.78%
Redzone
30/47 63.83%
54/119 0%
3rd Down
55/131 0%
3/7 0%
4th Down
12/14 0%

First Downs

218
Total
229
121
Pass
117
76
Rush
88
21
Penalty
24

Misc

/
Penalties/Yards
/
Possession

49ers vs. Bills Odds Comparison

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49ers at Bills Team Totals

MatchupOverUnder
49ers
5-5
N/A
N/A
Bills
9-2
N/A
N/A