Packers vs. Cardinals Odds & Betting Predictions - October 19, 2025
Packers at Cardinals
8:25 pm • FOXPackers at Cardinals Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
---|---|---|---|---|
![]() Packers 3-1-1 | -2.5 | -6.5-110 | o44.5-105 | -310 |
![]() Cardinals 2-4 | u47.5 | +6.5-110 | u44.5-115 | +250 |

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Packers vs. Cardinals Expert Picks

Brandon Anderson
Last 30d: 37-111-0 (-25.7u)
GB -4.5-115
2u
WEEK 7 LOOKAHEAD — Packers -4.5 at Cards (fd)
Sometimes with a Lookahead, you just have to keep it simple and look at what we expect this weekend.
The Packers are rested home favorites of two touchdowns, playing against a Bengals team so desperate for points that they turned to Joe Flacco this week. Green Bay is a massive favorite and should roll and remind everyone of its status as a Super Bowl contender.
The Cardinals, on the other hand, are touchdown underdogs in Indianapolis and expected to lose. We still don't know if Kyler Murray is healthy enough to play now or next week, and if he does play, the risk for re-injury is high.
If the Cards lose and the Packers roll, this line likely reopens around -6 or even -7 on Sunday night — and that's about where it should be for two teams in different weight classes. Come on, the Colts are -7.5 to Arizona but the rested Packers are -4.5? Make it make sense.
Five, six, and seven are all key numbers these days, so there's value grabbing this at -4.5 before that entire range. We're never getting Packers -4.5 again after Sunday's games, so grab it now at FanDuel.

Action Pod NFL Picks
Last 30d: 57-131-0 (-19.7u)
GB -4.5-110
1u
Week 7 Lookahead @wheatonbrando https://myaction.app/xBM2x7iamXb
Packers vs. Cardinals Previews & Analysis
Packers vs. Cardinals Props
Prop Projections
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Prop Odds Comparison
Line Movement Tracker
Packers vs. Cardinals Public Betting Percentages
Betting Trends
- Cardinals are 1-4 in their last 5 games.
- Cardinals are 3-2 in their last 5 games against the spread
- Cardinals are 3-0 in their road games against the spread
- The totals have gone OVER in 2 of Cardinals' last 5 games
- The totals have gone OVER in 2 of Cardinals' 3 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Packers vs. Cardinals Injury Updates

Packers Injuries
- Zayne AndersonS
Anderson is questionable with knee
Questionable
- Christian WatsonWR
Watson is out with knee
Out
- Jayden ReedWR
Reed is out with collarbone
Out
- MarShawn LloydRB
Lloyd is out with hamstring
Out
- Barryn SorrellDE
Sorrell is questionable with knee
Questionable

Cardinals Injuries
- James ConnerRB
Conner is out with foot
Out
- Kyler MurrayQB
Murray is out with foot
Out
- Owen PappoeLB
Pappoe is questionable with quad
Questionable
- Trey BensonRB
Benson is out with knee
Out
- Tip ReimanTE
Reiman is out with ankle
Out
Player Stats
- passing yardsKyler Murray962pyds
- passing touchdownsKyler Murray6ptd
- rushing yardsKyler Murray173ryds
- rushing touchdownsBam Knight2rtd
Depth Charts
Starter | 2ND | 3RD | 4TH | ||
---|---|---|---|---|---|
QB | Kyler Murray | Jacoby Brissett | |||
RB | James Conner | Trey Benson | Emari Demercado | Michael Carter | Bam Knight |
WR | Greg Dortch | Zay Jones | Andre Baccellia | ||
TE | Trey McBride | Tip Reiman | Elijah Higgins | Travis Vokolek | Josiah Deguara |
LT | Paris Johnson | Kelvin Beachum | |||
LG | Evan Brown | Nick Leverett | |||
C | Hjalte Froholdt | Jon Gaines | |||
RG | Isaiah Adams | Will Hernandez | Hayden Conner | ||
RT | Jonah Williams | Christian Jones | Josh Fryar | Jeremiah Byers | |
LDE | Calais Campbell | Walter Nolen | L.J. Collier | Anthony Goodlow | |
RDE | Darius Robinson | Justin Jones | Bilal Nichols | ||
WLB | Akeem Davis-Gaither | Owen Pappoe | |||
MLB | Mack Wilson | Cody Simon | J.J. Russell | ||
LCB | Will Johnson | Elijah Jones | |||
SS | Jalen Thompson | Dadrion Taylor-Demerson | |||
FS | Budda Baker | Joey Blount | Kitan Crawford | ||
RCB | Max Melton | Denzel Burke | |||
P | Blake Gillikin | ||||
H | Blake Gillikin | ||||
PR | Greg Dortch | Xavier Weaver | |||
KR | Greg Dortch | Andre Baccellia | |||
LS | Aaron Brewer | ||||
NB | Garrett Williams | Kei'Trel Clark | Darren Hall | ||
RWR | Michael Wilson | Xavier Weaver | |||
LWR | Marvin Harrison | Simi Fehoko | Tejhaun Palmer | ||
K | Chad Ryland | ||||
LOLB | Baron Browning | Zaven Collins | Jordan Burch | Elliott Brown | |
ROLB | Josh Sweat | BJ Ojulari | Xavier Thomas | ||
NT | Dalvin Tomlinson | Dante Stills | PJ Mustipher |
Team Stats
1187
YDS
1163
103/147
Comps/Atts
137/206
8.565
YPA
6.223
9/2
TDs/INTs
8/4
9/72
Sacks/Yards
18/119
15/21 71.43%
Redzone
13/23 56.52%
34/65 0%
3rd Down
36/82 0%
3/4 0%
4th Down
4/5 0%
Packers vs. Cardinals Odds Comparison
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Packers at Cardinals Team Totals
MatchupOverUnder | ||
---|---|---|
![]() Packers 3-1-1 | N/A | N/A |
![]() Cardinals 2-4 | N/A | N/A |