Packers vs. Cardinals Odds & Betting Predictions - October 19, 2025

Packers at Cardinals

8:25 pm • FOX
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Packers at Cardinals Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Packers
3-1-1
-2.5
-6.5-110
o44.5-105
-310
Cardinals
2-4
u47.5
+6.5-110
u44.5-115
+250
location pinSunday 8:25 p.m.
October 19, 2025
State Farm StadiumGlendale
thermometer image79°Fahrenheit
rain image0%Rain
wind image2Wind
Packers vs. Cardinals Expert Picks
Brandon Anderson
Brandon Anderson
Last 30d: 37-111-0 (-25.7u)
GB -4.5-115
2u
WEEK 7 LOOKAHEAD — Packers -4.5 at Cards (fd) Sometimes with a Lookahead, you just have to keep it simple and look at what we expect this weekend. The Packers are rested home favorites of two touchdowns, playing against a Bengals team so desperate for points that they turned to Joe Flacco this week. Green Bay is a massive favorite and should roll and remind everyone of its status as a Super Bowl contender. The Cardinals, on the other hand, are touchdown underdogs in Indianapolis and expected to lose. We still don't know if Kyler Murray is healthy enough to play now or next week, and if he does play, the risk for re-injury is high. If the Cards lose and the Packers roll, this line likely reopens around -6 or even -7 on Sunday night — and that's about where it should be for two teams in different weight classes. Come on, the Colts are -7.5 to Arizona but the rested Packers are -4.5? Make it make sense. Five, six, and seven are all key numbers these days, so there's value grabbing this at -4.5 before that entire range. We're never getting Packers -4.5 again after Sunday's games, so grab it now at FanDuel.
Action Pod NFL Picks
Action Pod NFL Picks
Last 30d: 57-131-0 (-19.7u)
GB -4.5-110
1u
Week 7 Lookahead @wheatonbrando https://myaction.app/xBM2x7iamXb

Packers vs. Cardinals Previews & Analysis

  • Anderson's Week 6 Picks, Props & Lookahead article feature image

    Anderson's Week 6 Picks, Props & Lookahead

    Brandon Anderson
    Oct 12, 2025 UTC
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Packers vs. Cardinals Props

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Packers vs. Cardinals Public Betting Percentages

Away Logo

Packers

Public

100%

Bets%

0%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Cardinals
3-30-33-01-22-1
Packers
2-32-10-22-3N/A

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Cardinals
3-32-11-22-11-2
Packers
2-31-21-12-3N/A

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Cardinals
2-4N/AN/A2-10-3
Packers
3-1-1N/AN/A3-1-1N/A

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Oct 12th@INDL 27-31+8.5 WO 46.5IND +350
Oct 5thTENL 21-22-7.5 LO 41.5TEN -420
Sep 26thSEAL 20-23+1.5 LU 43.5SEA +102
Sep 21st@SFL 15-16+1.5 WU 44.5SF +105
Sep 14thCARW 27-22-7 LO 45.5ARI -310

Packers vs. Cardinals Injury Updates

Packers Injuries

  • Zayne Anderson
    S

    Anderson is questionable with knee

    Questionable

  • Christian Watson
    WR

    Watson is out with knee

    Out

  • Jayden Reed
    WR

    Reed is out with collarbone

    Out

  • MarShawn Lloyd
    RB

    Lloyd is out with hamstring

    Out

  • Barryn Sorrell
    DE

    Sorrell is questionable with knee

    Questionable

Cardinals Injuries

  • James Conner
    RB

    Conner is out with foot

    Out

  • Kyler Murray
    QB

    Murray is out with foot

    Out

  • Owen Pappoe
    LB

    Pappoe is questionable with quad

    Questionable

  • Trey Benson
    RB

    Benson is out with knee

    Out

  • Tip Reiman
    TE

    Reiman is out with ankle

    Out

Player Stats
  • passing yards
    Kyler Murray logo
    Kyler Murray
    962
    pyds
  • passing touchdowns
    Kyler Murray logo
    Kyler Murray
    6
    ptd
  • rushing yards
    Kyler Murray logo
    Kyler Murray
    173
    ryds
  • rushing touchdowns
    Bam Knight logo
    Bam Knight
    2
    rtd
Depth Charts
Right Arrow
Starter2ND3RD4TH
QBKyler MurrayJacoby Brissett
RBJames ConnerTrey BensonEmari DemercadoMichael CarterBam Knight
WRGreg DortchZay JonesAndre Baccellia
TETrey McBrideTip ReimanElijah HigginsTravis VokolekJosiah Deguara
LTParis JohnsonKelvin Beachum
LGEvan BrownNick Leverett
CHjalte FroholdtJon Gaines
RGIsaiah AdamsWill HernandezHayden Conner
RTJonah WilliamsChristian JonesJosh FryarJeremiah Byers
LDECalais CampbellWalter NolenL.J. CollierAnthony Goodlow
RDEDarius RobinsonJustin JonesBilal Nichols
WLBAkeem Davis-GaitherOwen Pappoe
MLBMack WilsonCody SimonJ.J. Russell
LCBWill JohnsonElijah Jones
SSJalen ThompsonDadrion Taylor-Demerson
FSBudda BakerJoey BlountKitan Crawford
RCBMax MeltonDenzel Burke
PBlake Gillikin
HBlake Gillikin
PRGreg DortchXavier Weaver
KRGreg DortchAndre Baccellia
LSAaron Brewer
NBGarrett WilliamsKei'Trel ClarkDarren Hall
RWRMichael WilsonXavier Weaver
LWRMarvin HarrisonSimi FehokoTejhaun Palmer
KChad Ryland
LOLBBaron BrowningZaven CollinsJordan BurchElliott Brown
ROLBJosh SweatBJ OjulariXavier Thomas
NTDalvin TomlinsonDante StillsPJ Mustipher
Team Stats
1187
YDS
1163
103/147
Comps/Atts
137/206
8.565
YPA
6.223
9/2
TDs/INTs
8/4
9/72
Sacks/Yards
18/119
611
Rush Yards
679
154
Attempts
147
3.968
YPC
4.619
6
TDs
5
Fumbles Lost
2
Interceptions
4
15/21 71.43%
Redzone
13/23 56.52%
34/65 0%
3rd Down
36/82 0%
3/4 0%
4th Down
4/5 0%

First Downs

106
Total
110
57
Pass
67
37
Rush
33
12
Penalty
10
/
Penalties/Yards
/
Possession

Packers vs. Cardinals Odds Comparison

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Packers at Cardinals Team Totals

MatchupOverUnder
Packers
3-1-1
N/A
N/A
Cardinals
2-4
N/A
N/A