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Cardinals vs. Colts Odds & Betting Predictions - October 12, 2025

Cardinals at Colts

5:00 pm • FOX

Arizona Cardinals

2-3
@

Indianapolis Colts

4-1

Cardinals at Colts Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Cardinals
2-3
-1.5
+6.5-114
o47.5-110
+230
Colts
4-1
u47.5
-6.5-107
u47.5-110
-282
location pinSunday 5:00 p.m.
October 12, 2025
Lucas Oil StadiumIndianapolis
thermometer image67°Fahrenheit
rain image0%Rain
wind image4Wind
Cardinals vs. Colts Expert Picks
Kendra Middleton
Kendra Middleton
Last 30d: 10-7-0 (+2.1u)
IND +1.5-110
1u

Cardinals vs. Colts Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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Cardinals vs. Colts Public Betting Percentages

Away Logo

Cardinals

Public

Home Logo

Colts

45%

Bets%

55%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Colts are 4-1 in their last 5 games.
  • Colts are 4-1 in their last 5 games against the spread
  • Colts are 1-1 in their road games against the spread
  • The totals have gone OVER in 2 of Colts' last 5 games
  • The totals have gone OVER in 1 of Colts' 3 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Colts		4-13-01-13-01-1
Cardinals		2-30-32-01-21-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Colts		2-31-21-11-21-1
Cardinals		2-32-10-22-10-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Colts		4-1N/AN/A3-01-1
Cardinals		2-3N/AN/A2-10-2

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Oct 5thLVW 40-6-7.5 WU 46.5IND -370
Sep 28th@LAL 20-27+3.5 LU 49.5LA +154
Sep 21st@TENW 41-20-6 WO 42.5IND -258
Sep 14thDENW 29-28+1.5 WO 43.5IND +105
Sep 7thMIAW 33-8-1.5 WU 47IND -115

Cardinals vs. Colts Injury Updates

Cardinals Injuries

  • James Conner
    RB

    Conner is out with foot

    Out

  • Owen Pappoe
    LB

    Pappoe is questionable with quad

    Questionable

  • Trey Benson
    RB

    Benson is out with knee

    Out

Colts Injuries

  • Alec Pierce
    WR

    Pierce is out with concussion

    Out

  • Tyler Goodson
    RB

    Goodson is out with groin

    Out

See more NFL Injuries Right Arrow
Player Stats
  • passing yards
    Daniel Jones logo
    Daniel Jones
    1290
    pyds
  • passing touchdowns
    Daniel Jones logo
    Daniel Jones
    6
    ptd
  • rushing yards
    Jonathan Taylor logo
    Jonathan Taylor
    480
    ryds
  • rushing touchdowns
    Jonathan Taylor logo
    Jonathan Taylor
    6
    rtd
Depth Charts
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Starter2ND3RD4TH
QBDaniel JonesAnthony RichardsonRiley Leonard
RBJonathan TaylorTyler GoodsonDJ GiddensUlysses Bentley
WRJosh DownsAnthony GouldColeman Owen
TETyler WarrenMo Alie-CoxDrew OgletreeWill MallorySean McKeonMax Mang
LTBernhard RaimannJalen Travis
LGQuenton NelsonDalton Tucker
CTanor BortoliniDanny Pinter
RGMatt GoncalvesJosh SillsMarcellus Johnson
RTBraden SmithLuke Tenuta
LDEKwity PayeTyquan LewisJT Tuimoloau
RDELaiatu LatuSamson EbukamDurell Nchami
WLBJaylon CarliesAustin Ajiake
MLBZaire FranklinJoe BachieSegun Olubi
LCBCharvarius Ward
SSNick CrossDaniel Scott
FSCam BynumRodney ThomasTrey Washington
RCBJaylon JonesJohnathan Edwards
PRigoberto Sanchez
HRigoberto Sanchez
PRAnthony GouldJosh DownsColeman Owen
KRAnthony GouldAshton DulinTyler GoodsonDJ Giddens
LSLuke Rhodes
RWRAlec PierceAdonai Mitchell
LWRMichael PittmanAshton DulinLaquon Treadwell
NTGrover StewartNeville GallimoreEric Johnson
KSpencer Shrader
NBKenny MooreChris Lammons
DTDeForest BucknerAdetomiwa AdebaworeTim Smith
Team Stats

Passing

851
YDS
1265
110/162
Comps/Atts
108/153
5.938
YPA
8.49
6/3
TDs/INTs
6/2
16/111
Sacks/Yards
4/34

Rushing

591
Rush Yards
641
123
Attempts
146
4.805
YPC
4.39
4
TDs
11

Turnovers

Fumbles Lost
3
Interceptions
2

Efficiency

10/17 58.82%
Redzone
15/25 60%
27/68 0%
3rd Down
27/58 0%
4/4 0%
4th Down
6/8 0%

First Downs

85
Total
116
50
Pass
63
26
Rush
39
9
Penalty
14

Misc

/
Penalties/Yards
/
Possession

Cardinals vs. Colts Odds Comparison

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Cardinals at Colts Team Totals

MatchupOverUnder
Cardinals
2-3
N/A
N/A
Colts
4-1
N/A
N/A