Chiefs vs. Bills Odds & Betting Predictions - November 2, 2025
Chiefs at Bills
9:25 pm • CBSChiefs at Bills Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Chiefs 5-3 | +2.5 | -2-110 | o52.5-108 | -130 |
Bills 5-2 | u48.5 | +2-110 | u52.5-112 | +110 |

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Chiefs vs. Bills Expert Picks
David Payne
Last 30d: 8-11-0 (-3.5u)
K.Hunt Anytime TD Scorer Yes+122
$1.00
Fantasy Royale
Matt Moore
Last 30d: 40-46-0 (-2.5u)
BUF +108
0.55u
Lock & Cash
Last 30d: 21-14-0 (+9.9u)
KC -1-110
2u
FTN Fantasy
Last 30d: 43-43-0 (+1.8u)
KC -1.5-105
1u
Roger Goodell
Last 30d: 42-42-1 (+3.5u)
KC -1-110
1u
Chiefs vs. Bills Previews & Analysis
Chiefs vs. Bills Props
Prop Projections
There are no prop projections found for the selected slate. Please check back later.
Prop Odds Comparison
Line Movement Tracker
Chiefs vs. Bills Public Betting Percentages
Betting Trends
- Bills are 4-1 in their last 5 games.
- Bills are 2-3 in their last 5 games against the spread
- Bills are 2-1 in their road games against the spread
- The totals have gone OVER in 3 of Bills' last 5 games
- The totals have gone OVER in 3 of Bills' 4 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Chiefs vs. Bills Injury Updates

Chiefs Injuries
- Isiah PachecoRB
Pacheco is doubtful with knee
Doubtful
- Esa PoleT
Pole is out with ankle
Out

Bills Injuries
- Mitch WishnowskyP
Wishnowsky is out with back
Out
- Tyler BassK
Bass is out with hip
Out
- Joshua PalmerWR
Palmer is out with ankle
Out
Player Stats
- passing yards
Josh Allen1560pyds - passing touchdowns
Josh Allen12ptd - rushing yards
James Cook753ryds - rushing touchdowns
James Cook7rtd
Depth Charts
| Starter | 2ND | 3RD | 4TH | |
|---|---|---|---|---|
| QB | Josh Allen | Mitchell Trubisky | Shane Buechele | |
| RB | James Cook | Ray Davis | Ty Johnson | Frank Gore |
| WR | Khalil Shakir | Elijah Moore | Stephen Gosnell | |
| TE | Dalton Kincaid | Dawson Knox | Jackson Hawes | Keleki Latu |
| LT | Dion Dawkins | Tylan Grable | Chase Lundt | Travis Clayton |
| LG | David Edwards | Kendrick Green | ||
| C | Connor McGovern | Sedrick Van Pran-Granger | ||
| RG | O'Cyrus Torrence | Alec Anderson | ||
| RT | Spencer Brown | Ryan Van Demark | ||
| LDE | Greg Rousseau | Landon Jackson | Javon Solomon | |
| WLB | Matt Milano | Dorian Williams | Keonta Jenkins | |
| MLB | Terrel Bernard | Joe Andreessen | Shaq Thompson | Jimmy Ciarlo |
| LCB | Christian Benford | Maxwell Hairston | Dorian Strong | |
| SS | Cole Bishop | Cam Lewis | Wande Owens | |
| FS | Taylor Rapp | Damar Hamlin | Jordan Hancock | |
| RCB | Tre'Davious White | Dane Jackson | Ja'Marcus Ingram | |
| PR | Brandon Codrington | |||
| KR | Brandon Codrington | Elijah Moore | ||
| LS | Reid Ferguson | |||
| NT | DaQuan Jones | Deone Walker | Zion Logue | |
| LWR | Joshua Palmer | Tyrell Shavers | ||
| FB | Reggie Gilliam | |||
| K | Tyler Bass | |||
| NB | Taron Johnson | Brandon Codrington | ||
| DT | Ed Oliver | T.J. Sanders | DeWayne Carter | |
| RWR | Keon Coleman | Curtis Samuel | Kristian Wilkerson |
Team Stats
2014
YDS
1529
189/282
Comps/Atts
137/203
7.443
YPA
7.951
17/4
TDs/INTs
12/4
14/85
Sacks/Yards
14/85
Chiefs vs. Bills Odds Comparison
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Chiefs at Bills Team Totals
MatchupOverUnder | ||
|---|---|---|
Chiefs 5-3 | N/A | N/A |
Bills 5-2 | N/A | N/A |




