Chiefs vs. Bills Odds & Betting Predictions - November 2, 2025

Chiefs at Bills

9:25 pm • CBS
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Chiefs at Bills Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Chiefs
5-3
+2.5
-2-110
o52.5-108
-130
Bills
5-2
u48.5
+2-110
u52.5-112
+110
location pinSunday 9:25 p.m.
November 02, 2025
Highmark StadiumOrchard Park
thermometer image47°Fahrenheit
rain image0%Rain
wind image6Wind
Chiefs vs. Bills Expert Picks
David Payne
David Payne
Last 30d: 8-11-0 (-3.5u)
K.Hunt Anytime TD Scorer Yes+122
$1.00
Fantasy Royale
Matt Moore
Matt Moore
Last 30d: 40-46-0 (-2.5u)
BUF +108
0.55u
Lock & Cash
Lock & Cash
Last 30d: 21-14-0 (+9.9u)
KC -1-110
2u
FTN Fantasy
FTN Fantasy
Last 30d: 43-43-0 (+1.8u)
KC -1.5-105
1u
Roger Goodell
Roger Goodell
Last 30d: 42-42-1 (+3.5u)
KC -1-110
1u

Chiefs vs. Bills Previews & Analysis

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Chiefs vs. Bills Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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Chiefs vs. Bills Public Betting Percentages

Away Logo

Chiefs

Public

46%

Bets%

54%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Bills
3-41-32-12-41-0
Chiefs
5-34-11-14-21-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Bills
4-33-11-23-31-0
Chiefs
3-51-41-12-41-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Bills
5-2N/AN/A4-21-0
Chiefs
5-3N/AN/A4-21-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Oct 26th@CARW 40-9-7 WO 47.5BUF -395
Oct 13th@ATLL 14-24-3.5 LU 49.5ATL -202
Oct 6thNEL 20-23-7.5 LU 48.5NE -430
Sep 28thNOW 31-19-14.5 LO 48.5BUF -1500
Sep 19thMIAW 31-21-11.5 LO 50.5BUF -800

Chiefs vs. Bills Injury Updates

Chiefs Injuries

  • Isiah Pacheco
    RB

    Pacheco is doubtful with knee

    Doubtful

  • Esa Pole
    T

    Pole is out with ankle

    Out

Bills Injuries

  • Mitch Wishnowsky
    P

    Wishnowsky is out with back

    Out

  • Tyler Bass
    K

    Bass is out with hip

    Out

  • Joshua Palmer
    WR

    Palmer is out with ankle

    Out

Player Stats
  • passing yards
    Josh Allen logo
    Josh Allen
    1560
    pyds
  • passing touchdowns
    Josh Allen logo
    Josh Allen
    12
    ptd
  • rushing yards
    James Cook logo
    James Cook
    753
    ryds
  • rushing touchdowns
    James Cook logo
    James Cook
    7
    rtd
Depth Charts
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Starter2ND3RD4TH
QBJosh AllenMitchell TrubiskyShane Buechele
RBJames CookRay DavisTy JohnsonFrank Gore
WRKhalil ShakirElijah MooreStephen Gosnell
TEDalton KincaidDawson KnoxJackson HawesKeleki Latu
LTDion DawkinsTylan GrableChase LundtTravis Clayton
LGDavid EdwardsKendrick Green
CConnor McGovernSedrick Van Pran-Granger
RGO'Cyrus TorrenceAlec Anderson
RTSpencer BrownRyan Van Demark
LDEGreg RousseauLandon JacksonJavon Solomon
WLBMatt MilanoDorian WilliamsKeonta Jenkins
MLBTerrel BernardJoe AndreessenShaq ThompsonJimmy Ciarlo
LCBChristian BenfordMaxwell HairstonDorian Strong
SSCole BishopCam LewisWande Owens
FSTaylor RappDamar HamlinJordan Hancock
RCBTre'Davious WhiteDane JacksonJa'Marcus Ingram
PRBrandon Codrington
KRBrandon CodringtonElijah Moore
LSReid Ferguson
NTDaQuan JonesDeone WalkerZion Logue
LWRJoshua PalmerTyrell Shavers
FBReggie Gilliam
KTyler Bass
NBTaron JohnsonBrandon Codrington
DTEd OliverT.J. SandersDeWayne Carter
RWRKeon ColemanCurtis SamuelKristian Wilkerson
Team Stats
2014
YDS
1529
189/282
Comps/Atts
137/203
7.443
YPA
7.951
17/4
TDs/INTs
12/4
14/85
Sacks/Yards
14/85
1012
Rush Yards
1151
225
Attempts
221
4.498
YPC
5.208
9
TDs
13

Turnovers

Fumbles Lost
4
Interceptions
4

Efficiency

24/34 70.59%
Redzone
18/28 64.29%
44/100 0%
3rd Down
35/80 0%
14/17 0%
4th Down
3/5 0%

First Downs

189
Total
162
107
Pass
83
70
Rush
62
12
Penalty
17
/
Penalties/Yards
/
Possession

Chiefs vs. Bills Odds Comparison

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Chiefs at Bills Team Totals

MatchupOverUnder
Chiefs
5-3
N/A
N/A
Bills
5-2
N/A
N/A