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Patriots vs. Bills Odds & Betting Predictions - October 6, 2025

Patriots at Bills

12:20 am • NBC
Stream Live on SiriusXM - Free 3 Month Offer

New England Patriots

1-1
@

Buffalo Bills

2-0

Patriots at Bills Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Patriots
1-1
N/A
N/A
N/A
Bills
2-0
N/A
N/A
N/A
location pinMonday 12:20 a.m.
October 06, 2025
Highmark StadiumOrchard Park

Patriots vs. Bills Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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Patriots vs. Bills Public Betting Percentages

Away Logo

Patriots

Public

Home Logo

Bills

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Bills are 2-0 in their last 5 games.
  • Bills are 2-0 in their last 5 games against the spread
  • Bills are 1-0 in their road games against the spread
  • The totals have gone OVER in 1 of Bills' last 2 games
  • The totals have gone OVER in 1 of Bills' 1 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Bills		2-01-01-01-01-0
Patriots		1-10-11-00-11-0

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Bills		1-11-00-10-11-0
Patriots		1-10-11-00-11-0

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Bills		2-0N/AN/A1-01-0
Patriots		1-1N/AN/A0-11-0

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 14th@NYJW 30-10-6 WU 47.5BUF -290
Sep 8thBALW 41-40+1.5 WO 51.5BUF +105
Aug 23rd@TBW 23-19-1.5 WO 37.5BUF -125
Aug 18th@CHIL 0-38+2.5 LU 40.5CHI +120
Aug 9thNYGL 25-34-2.5 LO 37.5NYG -155

Patriots vs. Bills Injury Updates

Patriots Injuries

  • Christian Gonzalez
    CB

    Gonzalez is out with hamstring

    Out

  • Charles Woods
    CB

    Woods is questionable with concussion

    Questionable

Bills Injuries

  • Tyler Bass
    K

    Bass is out with hip

    Out

See more NFL Injuries Right Arrow
Player Stats
  • passing yards
    Josh Allen logo
    Josh Allen
    542
    pyds
  • passing touchdowns
    Josh Allen logo
    Josh Allen
    2
    ptd
  • rushing yards
    James Cook logo
    James Cook
    176
    ryds
  • rushing touchdowns
    James Cook logo
    James Cook
    3
    rtd
Depth Charts
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Starter2ND3RD4TH
QBJosh AllenMitchell TrubiskyShane Buechele
RBJames CookRay DavisTy JohnsonFrank Gore
WRKhalil ShakirElijah MooreStephen Gosnell
TEDalton KincaidDawson KnoxJackson HawesKeleki Latu
LTDion DawkinsTylan GrableChase LundtTravis Clayton
LGDavid EdwardsKendrick Green
CConnor McGovernSedrick Van Pran-Granger
RGO'Cyrus TorrenceAlec AndersonDan Feeney
RTSpencer BrownRyan Van Demark
LDEGreg RousseauLandon JacksonJavon Solomon
WLBMatt MilanoDorian WilliamsKeonta Jenkins
MLBTerrel BernardJoe AndreessenShaq ThompsonJimmy Ciarlo
LCBChristian BenfordMaxwell HairstonDorian Strong
SSCole BishopCam LewisWande Owens
FSTaylor RappDamar HamlinJordan Hancock
RCBTre'Davious WhiteDane JacksonJa'Marcus Ingram
PRBrandon Codrington
KRBrandon CodringtonElijah Moore
LSReid Ferguson
KTyler Bass
LWRJoshua PalmerTyrell Shavers
NBTaron JohnsonBrandon Codrington
RWRKeon ColemanCurtis SamuelKristian Wilkerson
FBReggie Gilliam
DTEd OliverT.J. SandersDeWayne Carter
NTDaQuan JonesDeone WalkerZion Logue
Team Stats

Passing

487
YDS
568
49/69
Comps/Atts
48/73
7.493
YPA
7.863
3/1
TDs/INTs
2/0
7/30
Sacks/Yards
2/6

Rushing

182
Rush Yards
332
47
Attempts
74
3.872
YPC
4.486
1
TDs
6

Turnovers

Fumbles Lost
1
Interceptions
0

Efficiency

4/7 57.14%
Redzone
7/11 63.64%
11/26 0%
3rd Down
12/29 0%
2/2 0%
4th Down
3/3 0%

First Downs

36
Total
54
24
Pass
27
10
Rush
21
2
Penalty
6

Misc

/
Penalties/Yards
/
Possession

Patriots vs. Bills Odds Comparison

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Patriots at Bills Team Totals

MatchupOverUnder
Patriots
1-1
N/A
N/A
Bills
2-0
N/A
N/A