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Bills vs. Panthers Odds & Betting Predictions - October 26, 2025

Bills at Panthers

5:00 pm • FOX

Buffalo Bills

4-1
@

Carolina Panthers

2-3

Bills at Panthers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Bills
4-1
N/A
N/A
N/A
Panthers
2-3
N/A
N/A
N/A
location pinSunday 5:00 p.m.
October 26, 2025
Bank of America StadiumCharlotte

Bills vs. Panthers Props

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Bills vs. Panthers Public Betting Percentages

Away Logo

Bills

Public

Home Logo

Panthers

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Panthers are 2-3 in their last 5 games.
  • Panthers are 3-2 in their last 5 games against the spread
  • Panthers are 1-2 in their road games against the spread
  • The totals have gone OVER in 3 of Panthers' last 5 games
  • The totals have gone OVER in 1 of Panthers' 2 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Panthers		3-22-01-2N/A3-2
Bills		2-31-31-01-31-0

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Panthers		3-21-12-1N/A3-2
Bills		3-23-10-12-21-0

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Panthers		2-3N/AN/AN/A2-3
Bills		4-1N/AN/A3-11-0

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Oct 5thMIAW 27-24+1.5 WO 44.5CAR -102
Sep 28th@NEL 13-42+5.5 LO 42.5NE +200
Sep 21stATLW 30-0+4.5 WU 44CAR +185
Sep 14th@ARIL 22-27+7 WO 45.5ARI +265
Sep 7th@JACL 10-26+4.5 LU 45.5JAC +184

Bills vs. Panthers Injury Updates

Bills Injuries

  • Mitch Wishnowsky
    P

    Wishnowsky is out with back

    Out

  • Tyler Bass
    K

    Bass is out with hip

    Out

Panthers Injuries

  • David Moore
    WR

    Moore is out with elbow

    Out

  • Chuba Hubbard
    RB

    Hubbard is questionable with calf

    Questionable

  • Ikem Ekwonu
    T

    Ekwonu is doubtful with illness

    Doubtful

  • Damarri Mathis
    CB

    Mathis is out with knee

    Out

  • Ja'Tavion Sanders
    TE

    Sanders is out with ankle

    Out

  • Jalen Coker
    WR

    Coker is out with quad

    Out

See more NFL Injuries Right Arrow
Player Stats
  • passing yards
    Bryce Young logo
    Bryce Young
    951
    pyds
  • passing touchdowns
    Bryce Young logo
    Bryce Young
    7
    ptd
  • rushing yards
    Rico Dowdle logo
    Rico Dowdle
    289
    ryds
  • rushing touchdowns
    Rico Dowdle logo
    Rico Dowdle
    2
    rtd
Depth Charts
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Starter2ND3RD4TH
QBBryce YoungAndy Dalton
RBChuba HubbardRico DowdleTrevor Etienne
WRJimmy HornHunter Renfrow
TEJa'Tavion SandersMitchell EvansJames MitchellBryce Pierre
LTIkem EkwonuBrady ChristensenMichael Tarquin
LGDamien Lewis
CAustin CorbettCade Mays
RGRobert HuntChandler Zavala
RTTaylor MotonYosh NijmanBrandon Walton
LDEDerrick BrownLaBryan RayJaden Crumedy
RDETershawn WhartonA'Shawn RobinsonJared Harrison-Hunte
LCBMike Jackson
SSTre'von MoehrigLathan Ransom
FSNick ScottDemani Richardson
RCBJaycee HornCorey ThorntonAkayleb Evans
PSam Martin
HSam Martin
PRTrevor EtienneJimmy HornDavid Moore
KRJimmy HornTrevor EtienneDavid Moore
LSJJ Jansen
RILBChristian RozeboomMapalo Mwansa
LWRTetairoa McMillanDavid MooreBrycen Tremayne
LILBTrevin WallaceClaudin CherelusKrys BarnesBam Martin-Scott
NTBobby BrownCam Jackson
NBChau Smith-WadeMichael ReidTrevian Thomas
RWRXavier LegetteJalen CokerJa'seem Reed
ROLBD.J. WonnumNic Scourton
LOLBPatrick JonesPrincely UmanmielenThomas IncoomBoogie Basham
KRyan Fitzgerald
Team Stats

Passing

1207
YDS
935
108/154
Comps/Atts
111/180
8.11
YPA
5.606
9/2
TDs/INTs
8/4
8/42
Sacks/Yards
9/74

Rushing

772
Rush Yards
640
162
Attempts
134
4.765
YPC
4.776
9
TDs
3

Turnovers

Fumbles Lost
2
Interceptions
4

Efficiency

14/22 63.64%
Redzone
10/15 66.67%
26/59 0%
3rd Down
26/66 0%
3/4 0%
4th Down
8/13 0%

First Downs

122
Total
103
65
Pass
57
43
Rush
32
14
Penalty
14

Misc

/
Penalties/Yards
/
Possession

Bills vs. Panthers Odds Comparison

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Bills at Panthers Team Totals

MatchupOverUnder
Bills
4-1
N/A
N/A
Panthers
2-3
N/A
N/A