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49ers vs. Colts Odds & Betting Predictions - December 23, 2025

49ers at Colts

1:15 am • ESPN

San Francisco 49ers

9-4
@

Indianapolis Colts

8-5

49ers at Colts Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
49ers
9-4
-3
-6.5-110
o45.5-115
-298
Colts
8-5
u46.5
+6.5-110
u45.5-105
+240
location pinTuesday 1:15 a.m.
December 23, 2025
Lucas Oil StadiumIndianapolis
thermometer image46°Fahrenheit
rain image0%Rain
wind image8Wind

49ers vs. Colts Props

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49ers vs. Colts Public Betting Percentages

Away Logo

49ers

Public

Home Logo

Colts

67%

Bets%

33%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Colts are 4-1 in their last 5 games.
  • Colts are 3-2 in their last 5 games against the spread
  • Colts are 3-3 in their road games against the spread
  • The totals have gone OVER in 2 of Colts' last 5 games
  • The totals have gone OVER in 3 of Colts' 6 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Colts		7-64-23-34-53-1
49ers		8-52-36-26-22-3

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Colts		7-63-33-35-42-2
49ers		7-62-35-34-43-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Colts		8-5N/AN/A6-32-2
49ers		9-4N/AN/A7-12-3

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Dec 7th@JACL 19-36-2.5 LO 44.5JAC -138
Nov 30thHOUL 16-20-3 LU 44.5HOU -166
Nov 23rd@KCL 20-23+4.5 WU 50KC +186
Nov 9thATLW 31-25-6.5 LO 48.5IND -270
Nov 2nd@PITL 20-27-3 LU 51.5PIT -168

49ers vs. Colts Injury Updates

49ers Injuries

  • Christian McCaffrey
    RB

    McCaffrey is questionable with back

    Questionable

  • Brandon Aiyuk
    WR

    Aiyuk is out with knee

    Out

  • Jacob Cowing
    WR

    Cowing is out with hamstring

    Out

Colts Injuries

  • Ashton Dulin
    WR

    Dulin is out with hamstring

    Out

  • Daniel Jones
    QB

    Jones is out with achilles

    Out

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Player Stats
  • passing yards
    Daniel Jones logo
    Daniel Jones
    3101
    pyds
  • passing touchdowns
    Daniel Jones logo
    Daniel Jones
    19
    ptd
  • rushing yards
    Jonathan Taylor logo
    Jonathan Taylor
    1356
    ryds
  • rushing touchdowns
    Jonathan Taylor logo
    Jonathan Taylor
    16
    rtd
Depth Charts
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Starter2ND3RD4TH
QBDaniel JonesAnthony RichardsonRiley Leonard
RBJonathan TaylorTyler GoodsonDJ GiddensUlysses Bentley
WRJosh DownsAnthony GouldColeman Owen
TETyler WarrenMo Alie-CoxDrew OgletreeWill MallorySean McKeon
LTBernhard RaimannJalen Travis
LGQuenton NelsonDalton Tucker
CTanor BortoliniDanny Pinter
RGMatt GoncalvesJosh Sills
RTBraden SmithLuke Tenuta
LDEKwity PayeTyquan LewisJT Tuimoloau
RDELaiatu LatuSamson EbukamDurell Nchami
WLBJaylon CarliesAustin Ajiake
MLBZaire FranklinSegun Olubi
LCBCharvarius Ward
SSNick CrossDaniel Scott
FSCam BynumRodney ThomasTrey Washington
RCBJaylon JonesJohnathan Edwards
PRigoberto Sanchez
HRigoberto Sanchez
PRAnthony GouldJosh DownsColeman Owen
KRAnthony GouldAshton DulinTyler GoodsonDJ Giddens
LSLuke Rhodes
KSpencer Shrader
NBKenny MooreChris Lammons
DTDeForest BucknerAdetomiwa AdebaworeTim Smith
NTGrover StewartNeville GallimoreEric Johnson
LWRMichael PittmanAshton DulinLaquon Treadwell
RWRAlec Pierce
Team Stats

Passing

3154
YDS
3088
307/450
Comps/Atts
280/418
7.329
YPA
7.787
22/13
TDs/INTs
19/9
20/144
Sacks/Yards
23/167

Rushing

1281
Rush Yards
1702
366
Attempts
342
3.5
YPC
4.977
11
TDs
24

Turnovers

Fumbles Lost
13
Interceptions
9

Efficiency

30/48 62.5%
Redzone
36/56 64.29%
81/168 0%
3rd Down
61/146 0%
10/17 0%
4th Down
17/24 0%

First Downs

282
Total
284
174
Pass
158
90
Rush
101
18
Penalty
25

Misc

/
Penalties/Yards
/
Possession

49ers vs. Colts Odds Comparison

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49ers at Colts Team Totals

MatchupOverUnder
49ers
9-4
N/A
N/A
Colts
8-5
N/A
N/A