Colts vs. Titans Odds & Betting Predictions - September 21, 2025
Colts at Titans
5:00 pm • CBSColts at Titans Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 Colts 2-0 | +1.5 | -3.5-111 | o43.5-110 | -192 |
 Titans 0-2 | u45.5 | +3.5-109 | u43.5-110 | +160 |
Nissan StadiumNashville
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Colts vs. Titans Expert Picks
Sandy Plashkes
Last 30d: 60-90-2 (-32.5u)
TEN +3.5-110
1.1u
Jim Sannes
Last 30d: 10-30-0 (+1.7u)
Under 43.5-114
1u
Have this at 39.9. Colts' offense has shredded but now moves outdoors to face a Titans defense that has been good enough so far.
Boomer Betz
Last 30d: 128-141-0 (-3.5u)
TEN +164
0.5u
Babs .
Last 30d: 70-53-1 (+15.0u)
IND -3-120
1u
Boomer Betz
Last 30d: 128-141-0 (-3.5u)
TEN +3.5-110
1u
Bet105
bit.ly/boomerh1
FTN Fantasy
Last 30d: 63-94-0 (-36.6u)
TEN +3.5-115
1u
Top Shelf Action 🥃
Last 30d: 129-150-2 (-28.7u)
Under 43.5-110
1u
Colts vs. Titans Previews & Analysis
Colts vs. Titans Props
Prop Projections
There are no prop projections found for the selected slate. Please check back later.
Prop Odds Comparison
Line Movement Tracker
Colts vs. Titans Public Betting Percentages
Betting Trends
- Titans are 0-2 in their last 5 games.
- Titans are 1-1 in their last 5 games against the spread
- Titans are 1-0 in their road games against the spread
- The totals have gone OVER in 1 of Titans' last 2 games
- The totals have gone OVER in 1 of Titans' 1 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Titans vs. Colts Injury Updates
Titans Injuries
- Tyjae SpearsRB
Spears is out with ankle
Out
- Kevin WinstonS
Winston is doubtful with hamstring
Doubtful
- Kalel MullingsRB
Mullings is questionable with ankle
Questionable
Colts Injuries
- Tyler GoodsonRB
Goodson is questionable with elbow
Questionable
Player Stats
- passing yards
Cam Ward287pyds - passing touchdownsCam Ward1ptd
- rushing yards
Tony Pollard152ryds - rushing touchdowns
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Depth Charts
| Starter | 2ND | 3RD | 4TH | ||
|---|---|---|---|---|---|
| QB | Cam Ward | Brandon Allen | Trevor Siemian | ||
| RB | Tony Pollard | Tyjae Spears | Kalel Mullings | Julius Chestnut | Jordan Mims |
| WR | Tyler Lockett | Chimere Dike | Xavier Restrepo | Mason Kinsey | |
| TE | Chig Okonkwo | Gunnar Helm | David Martin-Robinson | Thomas Odukoya | |
| LT | Dan Moore | John Ojukwu | Olisaemeka Udoh | ||
| LG | Peter Skoronski | Jackson Slater | Andrew Rupcich | ||
| C | Lloyd Cushenberry | Corey Levin | |||
| RG | Kevin Zeitler | Blake Hance | |||
| RT | JC Latham | Brandon Crenshaw-Dickson | |||
| RDE | Sebastian Joseph-Day | Carlos Watkins | |||
| LCB | L'Jarius Sneed | Darrell Baker | |||
| SS | Amani Hooker | Kevin Winston | |||
| FS | Xavier Woods | Quandre Diggs | Mike Brown | ||
| RCB | Jarvis Brownlee | Marcus Harris | |||
| P | Johnny Hekker | ||||
| H | Johnny Hekker | ||||
| PR | James Proche | Chimere Dike | Xavier Restrepo | ||
| KR | Chimere Dike | Tyjae Spears | |||
| LS | Morgan Cox | ||||
| RWR | Calvin Ridley | Bryce Oliver | |||
| RILB | Cody Barton | ||||
| LILB | James Williams | Cedric Gray | |||
| ROLB | Dre'Mont Jones | Jihad Ward | Ali Gaye | ||
| K | Joey Slye | ||||
| LWR | Van Jefferson | Elic Ayomanor | James Proche | ||
| DT | Jeffery Simmons | James Lynch | Cam Horsley | ||
| NT | T'Vondre Sweat | Timmy Horne | |||
| NB | Roger McCreary | ||||
| LOLB | Arden Key | Oluwafemi Oladejo | Jaylen Harrell |
Team Stats
Colts vs. Titans Odds Comparison
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Colts at Titans Team Totals
MatchupOverUnder | ||
|---|---|---|
Colts 2-0 | N/A | N/A |
Titans 0-2 | N/A | N/A |