Buccaneers vs. Bills Odds & Betting Predictions - November 16, 2025
Buccaneers at Bills
6:00 pm • CBSBuccaneers at Bills Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 Buccaneers 6-2 | N/A | N/A | N/A | |
 Bills 5-2 | N/A | N/A | N/A | |
Highmark StadiumOrchard Park
Buccaneers vs. Bills Props
Prop Projections
There are no prop projections found for the selected slate. Please check back later.
Prop Odds Comparison
Line Movement Tracker
Buccaneers vs. Bills Public Betting Percentages
Betting Trends
- Bills are 4-1 in their last 5 games.
- Bills are 2-3 in their last 5 games against the spread
- Bills are 2-1 in their road games against the spread
- The totals have gone OVER in 3 of Bills' last 5 games
- The totals have gone OVER in 3 of Bills' 4 last games at home
Matchup History
Against the Spread (ATS) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 3-4 | 1-3 | 2-1 | 2-4 | 1-0 |
| 5-3 | 1-2 | 4-1 | 3-1 | 2-2 |
Over/Under History
| overall | home o/u | away o/u | favorite o/u | underdog o/u | |
|---|---|---|---|---|---|
| 4-3 | 3-1 | 1-2 | 3-3 | 1-0 |
| 4-4 | 3-0 | 1-4 | 2-2 | 2-2 |
Straight-Up (ML) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 5-2 | N/A | N/A | 4-2 | 1-0 |
| 6-2 | N/A | N/A | 4-0 | 2-2 |
Last 5 Matchups
Buccaneers vs. Bills Injury Updates
Buccaneers Injuries
- Mike EvansWR
Evans is out with collarbone
Out
- Chris GodwinWR
Godwin is out with leg
Out
- Ko KieftTE
Kieft is out with leg
Out
- Christian IzienS
Izien is out with oblique
Out
- Bucky IrvingRB
Irving is out with foot
Out
- Benjamin MorrisonCB
Morrison is out with quad
Out
Bills Injuries
- Mitch WishnowskyP
Wishnowsky is out with back
Out
- Tyler BassK
Bass is out with hip
Out
- Joshua PalmerWR
Palmer is out with ankle
Out
Player Stats
- passing yards
Josh Allen1560pyds - passing touchdownsJosh Allen12ptd
- rushing yards
James Cook753ryds - rushing touchdownsJames Cook7rtd
Depth Charts
| Starter | 2ND | 3RD | 4TH | |
|---|---|---|---|---|
| QB | Josh Allen | Mitchell Trubisky | Shane Buechele | |
| RB | James Cook | Ray Davis | Ty Johnson | Frank Gore |
| WR | Khalil Shakir | Elijah Moore | Stephen Gosnell | |
| TE | Dalton Kincaid | Dawson Knox | Jackson Hawes | Keleki Latu |
| LT | Dion Dawkins | Tylan Grable | Chase Lundt | Travis Clayton |
| LG | David Edwards | Kendrick Green | ||
| C | Connor McGovern | Sedrick Van Pran-Granger | ||
| RG | O'Cyrus Torrence | Alec Anderson | ||
| RT | Spencer Brown | Ryan Van Demark | ||
| LDE | Greg Rousseau | Landon Jackson | Javon Solomon | |
| WLB | Matt Milano | Dorian Williams | Keonta Jenkins | |
| MLB | Terrel Bernard | Joe Andreessen | Shaq Thompson | Jimmy Ciarlo |
| LCB | Christian Benford | Maxwell Hairston | Dorian Strong | |
| SS | Cole Bishop | Cam Lewis | Wande Owens | |
| FS | Taylor Rapp | Damar Hamlin | Jordan Hancock | |
| RCB | Tre'Davious White | Dane Jackson | Ja'Marcus Ingram | |
| PR | Brandon Codrington | |||
| KR | Brandon Codrington | Elijah Moore | ||
| LS | Reid Ferguson | |||
| NT | DaQuan Jones | Deone Walker | Zion Logue | |
| LWR | Joshua Palmer | Tyrell Shavers | ||
| FB | Reggie Gilliam | |||
| K | Tyler Bass | |||
| NB | Taron Johnson | Brandon Codrington | ||
| DT | Ed Oliver | T.J. Sanders | DeWayne Carter | |
| RWR | Keon Coleman | Curtis Samuel | Kristian Wilkerson |
Team Stats
1799
YDS
1529
172/269
Comps/Atts
137/203
7.134
YPA
7.951
13/2
TDs/INTs
12/4
17/120
Sacks/Yards
14/85
Buccaneers vs. Bills Odds Comparison
Could not load odds
Buccaneers at Bills Team Totals
MatchupOverUnder | ||
|---|---|---|
Buccaneers 6-2 | N/A | N/A |
Bills 5-2 | N/A | N/A |