Buccaneers vs. Bills Odds & Betting Predictions - November 16, 2025

Buccaneers at Bills

6:00 pm • CBS

Tampa Bay Buccaneers

6-4

32 - 44

Buffalo Bills

7-3

MatchupOpenSpreadTotalMoneyline
Buccaneers 6-4	+6	+6.5-110	o46.5-110	+245
Bills 7-3	u50.5	-6.5-110	u46.5-110	-305

Sunday 6:00 p.m.

November 16, 2025

Highmark StadiumOrchard Park

E.Egbuka Anytime TD Scorer Yes (Live)+140

0.5u

BUF -6-105

TB +7-130

0.5u

Boyd / FanDuel

Under 47.5-105

Link in bio for early Access

B.Mayfield o30.5 Pass Att-108

1.25u

📚Player Profit 🔑 B.Mayfield o30.5 Pass Attempts -108 (Player Profit) 1.25u Betalytics POTD 5 ⭐️ grade, 60.4% expected win probability Code: sirlocks for 10% off when you get funded at https://www.playerprofit.com/ For BA tools: https://www.betalytics.com/ Promo code: LOCKSELOT for 25% off

D.Knox Anytime TD Scorer Yes+380

0.25u

Touchdown Show

BUF -5.5-120

1.25u

Under 22.5 (1H)+110

0.6u

2.51% ev play to +105

BUF -6-110

0.91u

BUF u27.5-120

1.2u

BUF -0.5 (1Q)+110

0.77u

3.17% ev play to +104

J.Palmer o25.5 Rec Yds-114

A.Winfield u5.5 Tackles + Ast-110

0.55u

Tailing @The_Oddsmaker

A.Winfield u5.5 Tackles + Ast-110

0.55u

Proj closer to 5.1 with around a 61% chance to stay under 5.5

J.Allen o9.5 Rush Att+350

0.25u

Alt line of 10+ https://www.actionnetwork.com/nfl/nfl-predictions-week-11-expert-data-driven-picks-for-sunday-nov-16

J.Allen o7.5 Rush Att-110

0.55u

https://www.actionnetwork.com/nfl/nfl-predictions-week-11-expert-data-driven-picks-for-sunday-nov-16

J.Allen o6.5 Rush Att-140

0.7u

https://www.actionnetwork.com/nfl/nfl-predictions-week-11-expert-data-driven-picks-for-sunday-nov-16

D.Knox u2.5 Recs-112

0.5u

Tailing @The_Oddsmaker

D.Knox u2.5 Recs-112

0.5u

Projecting closer to 2.2 rec and around a 59% chance he stays under 2.5

J.Palmer o1.5 Recs-130

0.77u

TB +6-112

#SundaySixPack

T.Johnson Anytime TD Scorer Yes+280

0.5u

@The_Oddsmaker https://myaction.app/IlEcwUOFiYb

J.Hawes Anytime TD Scorer Yes+500

0.5u

@The_Oddsmaker https://myaction.app/IlEcwUOFiYb

K.Shakir o4.5 Recs-112

Over 46.5-110

0.91u

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Under 47.5-110

1.1u

Under 48.5-115

@Stuckey2 https://myaction.app/x6YDsFhwfYb

TB +5.5-110

@ChrisRaybon https://myaction.app/x6YDsFhwfYb

TB +5.5-110

1.1u

@ChrisRaybon 1 https://myaction.app/WNap0ETvfYb

TB +5.5-112

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No props found

NFL Public Betting

Bills are 4-1 in their last 5 games.
Bills are 2-3 in their last 5 games against the spread
Bills are 2-2 in their road games against the spread
The totals have gone OVER in 4 of Bills' last 5 games
The totals have gone OVER in 4 of Bills' 6 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Bills	5-5	3-3	2-2	3-5	2-0
Buccaneers	5-5	1-3	4-2	3-2	2-3

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Bills	5-5	4-2	1-3	4-4	1-1
Buccaneers	6-4	4-0	2-4	3-2	3-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Bills	7-3	N/A	N/A	5-3	2-0
Buccaneers	6-4	N/A	N/A	4-1	2-3

date	opponent	score	spread	over/under	moneyline
Nov 9th	@MIA	L 13-30	-8.5 L	U 50	MIA -445
Nov 2nd	KC	W 28-21	+2.5 W	U 53	BUF +114
Oct 26th	@CAR	W 40-9	-7 W	O 47.5	BUF -395
Oct 13th	@ATL	L 14-24	-3.5 L	U 49.5	ATL -202
Oct 6th	NE	L 20-23	-7.5 L	U 48.5	NE -430

Mike Evans
WR
Evans is out with collarbone
Out
Chris Godwin
WR
Godwin is out with leg
Out
Ko Kieft
TE
Kieft is out with leg
Out
Christian Izien
S
Izien is out with oblique
Out
Bucky Irving
RB
Irving is out with foot
Out
Benjamin Morrison
CB
Morrison is out with quad
Out

Mitch Wishnowsky
P
Wishnowsky is out with back
Out
Tyler Bass
K
Bass is out with hip
Out
Dalton Kincaid
TE
Kincaid is out with hamstring
Out

See more NFL Injuries

Buccaneers

Total

Bills

367

Total Yards

414

Total Plays

5.4

Yards Per Play

7.8

Buccaneers

Passing

Bills

173

YDS

317

16/28

Comps/Atts

19/30

5.69

YPA

10.567

1/1

TDs/INTs

3/2

1/8

Sacks/Yards

0/0

Buccaneers

Rushing

Bills

202

Rush Yards

Attempts

5.179

YPC

4.217

TDs

Buccaneers

Turnovers

Bills

Fumbles Lost

Interceptions

Buccaneers

Efficiency

Bills

2/4 50%

Redzone

3/4 75%

9/16 0%

3rd Down

6/11 0%

1/1 0%

4th Down

1/2 0%

Buccaneers

First Downs

Bills

Total

Pass

Rush

Penalty

Buccaneers

Misc

Bills

2/30

Penalties/Yards

7/45

35:07

Possession

24:53

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MatchupOverUnder
Buccaneers 6-4	o20.5-105	u20.5-125
Bills 7-3	o26.5-130	u26.5+100

Buccaneers vs. Bills Odds & Betting Predictions - November 16, 2025

Buccaneers at Bills

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Buffalo Bills

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Prop Projections

Prop Odds Comparison

Line Movement Tracker

Buccaneers vs. Bills Public Betting Percentages

Buccaneers

Public

Bills

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

Buccaneers vs. Bills Injury Updates

Buccaneers Injuries

Bills Injuries

Buccaneers vs. Bills Odds Comparison

Buccaneers at Bills Team Totals