49ers vs. Seahawks Odds & Betting Predictions - January 17, 2026

49ers at Seahawks

4:00 pm
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49ers at Seahawks Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
49ers
1-0
+7
+7.5-110
o45.5-111
+290
Seahawks
0-0
u45.5
-7.5-110
u45.5-110
-360
location pinSaturday 4:00 p.m.
January 17, 2026
Lumen FieldSeattle, WA
thermometer image39°Fahrenheit
rain image0%Rain
wind image3Wind
49ers vs. Seahawks Expert Picks
Brandon Anderson
Brandon Anderson
Last 30d: 59-143-6 (-2.8u)
Under 47.5-108
1.5u
🔥 Divisional Round Hot Read 🔥
FTN Fantasy
FTN Fantasy
Last 30d: 184-164-1 (-2.0u)
SF +7-109
3u

49ers vs. Seahawks Previews & Analysis

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49ers vs. Seahawks Props

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Prop Odds Comparison

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49ers vs. Seahawks Public Betting Percentages

Away Logo

49ers

Public

100%

Bets%

0%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Seahawks
12-54-48-110-42-1
49ers
1-03-51-08-31-0

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Seahawks
9-85-34-58-61-2
49ers
0-14-40-17-40-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Seahawks
14-36-28-113-11-2
49ers
1-05-3N/A10-11-0

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jan 4th@SFW 13-3-2.5 WU 48.5SEA -155
Dec 28th@CARW 27-10-6.5 WU 42.5SEA -320
Dec 19thLAW 38-37-1.5 LO 42.5SEA -130
Dec 14thINDW 18-16-12.5 LU 41.5SEA -800
Dec 7th@ATLW 37-9-7 WO 44.5SEA -350

49ers vs. Seahawks Injury Updates

49ers Injuries

  • Brandon Aiyuk
    WR

    Aiyuk is out with knee

    Out

  • Ricky Pearsall
    WR

    Pearsall is out with knee

    Out

  • Jacob Cowing
    WR

    Cowing is out with hamstring

    Out

Seahawks Injuries

  • Cody White
    WR

    White is out with groin

    Out

  • Dareke Young
    WR

    Young is out with quad

    Out

  • George Holani
    RB

    Holani is out with hamstring

    Out

  • Elijah Arroyo
    TE

    Arroyo is out with knee

    Out

  • Tory Horton
    WR

    Horton is out with groin

    Out

Player Stats
  • passing yards
    Sam Darnold logo
    Sam Darnold
    4048
    pyds
  • passing touchdowns
    Sam Darnold logo
    Sam Darnold
    25
    ptd
  • rushing yards
    Kenneth Walker logo
    Kenneth Walker
    1027
    ryds
  • rushing touchdowns
    Zach Charbonnet logo
    Zach Charbonnet
    12
    rtd
Depth Charts
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Starter2ND3RD4TH
QBSam DarnoldDrew LockJalen Milroe
RBKenneth WalkerZach CharbonnetGeorge HolaniJacardia Wright
WRCooper KuppDareke Young
TEAJ BarnerElijah ArroyoEric SaubertNick Kallerup
LTCharles CrossAmari Kight
LGGrey ZabelBryce Cabeldue
COlu OluwatimiJalen SundellFederico Maranges
RGAnthony BradfordChristian HaynesMason Richman
RTAbraham LucasJosh Jones
LDEDeMarcus LawrenceDerick HallJared IveyConnor O'Toole
RDELeonard WilliamsMike MorrisJ.R. Singleton
WLBTyrice KnightPatrick O'ConnellJamie Sheriff
MLBErnest JonesDrake Thomas
LCBJosh JobeNehemiah PritchettShemar Jean-Charles
SSJulian LoveNick Emmanwori
FSCoby BryantTy Okada
RCBRiq WoolenShaquill Griffin
PMichael Dickson
HMichael Dickson
PRTory Horton
KRTory HortonZach Charbonnet
LSChris Stoll
NTByron MurphyBrandon Pili
FBRobbie OuztsBrady Russell
ROLBJamie SheriffConnor O'Toole
NBDevon WitherspoonTyler Hall
LOLBUchenna NwosuBoye Mafe
KJason Myers
DTJarran ReedRylie MillsWy'Kevious Thomas
RWRTory HortonRicky White
LWRJaxon Smith-NjigbaJake BoboCody WhiteTyrone Broden
Team Stats
4157
YDS
3877
398/574
Comps/Atts
325/481
7.523
YPA
8.447
33/16
TDs/INTs
25/15
27/161
Sacks/Yards
27/186
1817
Rush Yards
2096
481
Attempts
507
3.778
YPC
4.134
15
TDs
19

Turnovers

Fumbles Lost
16
Interceptions
15

Efficiency

43/66 65.15%
Redzone
32/59 54.24%
106/213 0%
3rd Down
82/206 0%
13/22 0%
4th Down
7/12 0%

First Downs

379
Total
340
237
Pass
179
119
Rush
125
23
Penalty
36
/
Penalties/Yards
/
Possession

49ers vs. Seahawks Odds Comparison

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49ers at Seahawks Team Totals

MatchupOverUnder
49ers
1-0
N/A
N/A
Seahawks
0-0
N/A
N/A