Virginia vs. Louisville Odds & Betting Predictions - October 4, 2025

Virginia at Louisville

7:30 pm • ESPN2

Virginia Cavaliers

11-3

30 - 27

Louisville Cardinals

9-4

MatchupOpenSpreadTotalMoneyline
Virginia 11-3	+7.5	+6.5-110	o60-110	+195
Louisville 9-4	u59.5	-6.5-115	u60-110	-245

Saturday 7:30 p.m.

October 04, 2025

L&N Federal Credit Union StadiumLouisville

LOU +220 (Live)

0.5u

Fuck!

Over 58.5-133

0.67u

Alternate Number at DK

LOU o33.5 Team Total-125

LOU -6.5-110

0.55u

Tailing @Bet_Labs

LOU -6.5-105

0.26u

LOU -6.5-115

1.73u

LOU -6.5-110

1.1u

LOU -6.5-110

1.1u

LOU -6.5-110

Red birds take a dookie

C.Morris u267.5 Pass Yds-115

0.5u

LOU -6.5-115

0.58u

Fading VA after the win of their season.

Under 63-110

0.91u

UVA +7.5-115

Easy call here. Two evenly matched teams. Lou 2x fortunate to get out of Pitt with a w. I like wahoos to compete here.

LOU -7-110

LOU -5.5-110

POD

Collin Wilson's Week 6 ML Round Robin
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Oct 4, 2025 UTC
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See more NCAAF Coverage

No props found

NCAAF Public Betting

Louisville are 3-2 in their last 5 games.
Louisville are 2-3 in their last 5 games against the spread
Louisville are 3-1 in their road games against the spread
The totals have gone OVER in 2 of Louisville' last 5 games
The totals have gone OVER in 4 of Louisville' 8 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Louisville	4-8	1-7	3-1	2-7	2-1
Virginia	8-5	5-2	3-2	5-4	3-1

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Louisville	5-7	4-4	1-3	5-4	0-3
Virginia	5-8	4-3	1-4	3-6	2-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Louisville	8-4	N/A	N/A	6-3	2-1
Virginia	10-3	N/A	N/A	7-2	3-1

date	opponent	score	spread	over/under	moneyline
Sep 27th	@PITT	W 34-27	-6.5 W	O 53.5	LOU -155
Sep 20th	BGSU	W 40-17	-26.5 L	O 50.5	LOU -4000
Sep 5th	JMU	W 28-14	-15.5 L	U 56.5	LOU -690
Aug 30th	EKU	W 51-17	-38.5 L	O 56.5	LOU -4875
Dec 31st	@WASH	W 35-34	+1 W	O 50.5	LOU -102

Virginia

Total

Louisville

237

Total Yards

383

Total Plays

3.761904761904762

Yards Per Play

5.1066666666666665

Virginia

Passing

Louisville

149

YDS

329

19/31

Comps/Atts

34/48

4.806451612903226

YPA

6.854166666666667

1/0

TDs/INTs

2/1

2/20

Sacks/Yards

5/46

Virginia

Rushing

Louisville

Rush Yards

Attempts

2.75

YPC

TDs

Virginia

Turnovers

Louisville

Fumbles Lost

Interceptions

Virginia

Efficiency

Louisville

2/2 100%

Redzone

4/4 100%

6/15 0%

3rd Down

7/17 0%

2/3 0%

4th Down

1/2 0%

Virginia

First Downs

Louisville

Total

Pass

Rush

Penalty

Virginia

Misc

Louisville

7/68

Penalties/Yards

5/60

Could not load odds

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MatchupOverUnder
Virginia 11-3	N/A	N/A
Louisville 9-4	N/A	N/A

Virginia vs. Louisville Odds & Betting Predictions - October 4, 2025

Virginia at Louisville

Virginia Cavaliers

Louisville Cardinals

Virginia at Louisville Odds

Spread, Total, Moneyline

Virginia vs. Louisville Previews & Analysis

Collin Wilson's Week 6 ML Round Robin

Your Week 6 NCAAF Betting Cheat Sheet

Virginia vs. Louisville: No Hangover for Hoos

NCAAF Betting Primer: What to Know for Week 6

Prop Odds Comparison

Line Movement Tracker

Virginia vs. Louisville Public Betting Percentages

Virginia

Public

Louisville

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

Virginia vs. Louisville Odds Comparison

Virginia at Louisville Team Totals