Louisville logo

Louisville Cardinals Odds

Next Louisville Game

Game Details
vs Clemson Tigers
Clemson
location pin
Sat 11/1512:30 AM

Louisville vs Clemson Odds

More Odds
SpreadTotalMoneyline
CLEM
+2.5-110
o50.5-115
+110
LOU
-2.5-110
u50.5-110
-130

Cardinals Injuries

All NCAAF Injuries

There are no injuries for this team currently.

Picks
The Pick Don
The Pick Don
Last 30d: 12-6-0 (+7.5u)
I’ve had this spot circled for weeks. Imagine if I showed you this line in the off season. You probably would have put your rent on the Tigers. Well, here we are with two teams that have had drastically different seasons. Clemson entered the year as National Championship contenders, but we all know how that has gone. Meanwhile, Louisville has shocked a lot of people with how their season has unfolded. Unfortunately for the Cardinals, they controlled their own destiny to the ACC Championship last week but lost as 18 point favorites to California at home. It was a demoralizing loss for Louisville, who clearly overlooked a bad Cal team. Louisville went from a potential College Football Playoff team to one that now needs plenty of help just to make the ACC Championship game. They now sit with the 6th best odds to get there. Talk about a brutal turn of events. This is something a model can’t properly calculate. Another thing a model can’t fully factor is the impact of RB Isaac Brown, whose absence has clearly been felt. He missed last week’s loss with an injury and will miss today’s game. The offense runs through Brown, and losing him is a big blow for the Cardinals. Brown ran for 151 yards last year against Clemson. I’ve given Miller Moss praise a few times this season, but I’ve been pretty unimpressed as of late. Despite what many thought, the Clemson defense hasn’t given up on Dabo Swinney. They showed an inspired performance last week, allowing just 10 points to Florida State. This was the type of performance we were expecting from this unit all season. Clemson’s defense is littered with NFL talent. Avieon Terrell, TJ Parker, and Peter Woods are all NFL bound next year and are putting the finishing touches on their college tapes for scouts. I think this Clemson team is as motivated as ever to right the ship on a lost season and show how good they still can be. We also have to remember how unlucky Clemson has been. They rank as the third unluckiest team in our NCAAF luck rankings. One of their losses came with a backup quarterback under center, and in three of the others they were simply on the wrong side of a one score game. Clemson has four wins but 6.1 dWIN (deserved wins). This team is not nearly as bad as their record suggests. QB Cade Klubnik hasn’t given up on the season either. Since Clemson’s Week 5 bye, the offense with Klubnik is averaging 37 points per game. The Louisville defense is good, but they also have injury concerns. AJ Green and Tayon Holloway come into this game banged up and questionable. The defense is Louisville’s strength, but key injuries could lessen their impact against a very good Clemson offense. As mentioned, the Louisville rushing attack is their bread and butter, but without Isaac Brown, more weight falls on Miller Moss’s shoulders. Moss has just an 11 to 7 TD-to-INT ratio this season. Clemson’s defense has been gashed through the air at times, but Louisville’s passing attack grades out at just 63.6 (90th). I don’t think Louisville has the proper tools to fully expose Clemson’s secondary. This is also a revenge spot for Clemson after Louisville came into Death Valley last season and beat them 33–21 in a game that was never close. Clemson has three games left and needs to win two to become bowl eligible. This is a big game for Clemson despite the season feeling lost. Forget the points, I think Clemson comes into Louisville under the primetime lights and gets the win.
9
Big Bets On Campus (CFB)
Big Bets On Campus (CFB)
Last 30d: 40-40-1 (-1.0u)
Roger Goodell
Roger Goodell
Last 30d: 8-8-0 (+0.3u)
Under 51.5-110
CLEM
CLEM Team Abbreviation@LOU Team Abbreviation
LOU
0.5u
11/15 12:30 AM
13
Lines at Lunch
Lines at Lunch
Last 30d: 6-12-0 (-7.7u)
CLEM +2.5-110
CLEM
CLEM Team Abbreviation@LOU Team Abbreviation
LOU
1.1u
11/15 12:30 AM
Sandy Plashkes
Sandy Plashkes
Last 30d: 22-21-0 (-0.3u)
CLEM +2.5-110
CLEM
CLEM Team Abbreviation@LOU Team Abbreviation
LOU
1.1u
11/15 12:30 AM
2
Brian Bitler
Brian Bitler
Last 30d: 26-20-0 (+13.0u)
Under 51-109
CLEM
CLEM Team Abbreviation@LOU Team Abbreviation
LOU
3u
11/15 12:30 AM
4
Collin Wilson
Collin Wilson
Last 30d: 81-62-0 (+13.9u)
CLEM +3-115
CLEM
CLEM Team Abbreviation@LOU Team Abbreviation
LOU
1.1u
11/15 12:30 AM
169

Cardinals 2025 Schedule & Betting Odds

dateopponentscorespreadover/undermoneyline
Nov 29thUK----
Nov 22nd@SMU----
Nov 15thCLEM----
Nov 9thCALL 26-29-18.5 LO 48.5CAL -1100
Nov 1st@VTW 28-16-10.5 WU 52.5LOU -395
Oct 25thBCW 38-24-25.5 LO 54.5LOU -2800
Oct 17th@MIAW 24-21+10.5 WU 49.5LOU +340
Oct 4thUVAL 27-30-6.5 LU 60UVA -245
Sep 27th@PITTW 34-27-6.5 WO 53.5LOU -155
Sep 20thBGSUW 40-17-26.5 LO 50.5LOU -4000
News
  • Clemson vs. Louisville: Win on the Ground article feature image

    Clemson vs. Louisville: Win on the Ground

    Greg Liodice
    Nov 14, 2025 UTC
  • Kentucky vs Louisville: How to Bet This Juicy Rivalry Duel article feature image

    Kentucky vs Louisville: How to Bet This Juicy Rivalry Duel

    Dead President Picks
    Nov 11, 2025 UTC
  • Our Staff's Best Bets for Louisville vs Kentucky article feature image

    Our Staff's Best Bets for Louisville vs Kentucky

    Action Network Staff
    Nov 11, 2025 UTC
  • Cal vs. Louisville: Value in First Half article feature image

    Cal vs. Louisville: Value in First Half

    Doug Ziefel
    Nov 8, 2025 UTC

Louisville Cardinals Football

The Louisville Cardinals are headed by Coach Jeff Brohm, leading the team to a successful season after just 2 years with the team. The Cardinals finished with a 9-4 record, with a 35-35 win in the Sun Bowl. 

The team will play Eastern Kentucky Colonels on August 30th at the L&N Stadium before taking on the James Madison Dukes.

Louisville Cardinals Point Spreads

Here’s an example of a past Cards game vs. Pittsburgh point spread.

  • Louisville +3 (-110)
  • Pittsburgh -3 (-110)

The Cardinals lost the game, 23-20, making the bet a tie or a push. This means bettors on either side got their money back. For Cardinals bets to have won, they would’ve needed to win the game or lose by one or two points. Pittsburgh backers would have needed a win by four or more for their bets to cash.

Louisville Cardinals Over/Unders

Another popular bet that can be made on college football games is an over/under or total bet. With these bets, neither the winner of the game nor the winning margin matters. Instead, you’re betting on the combined scoring of the teams.

Using their game against Georgia Tech as an example, books set the total at 54. The game finished 39-34 for Tech for a combined 73 points. This was a winner for anyone who bet the over. Had the teams combined for fewer than 63 points, under bets would have cashed; if it landed at exactly 63, both sides would've gotten their stake back.

Louisville Cardinals Moneylines

Another common college football bet is a moneyline bet. Instead of handicapping a team by a certain number of points, oddsmakers adjust the payout based on the chances either team has of winning.

Moneyline bets are easiest to understand if you think in units of $100. Were the Cardinals to defeat Georgia Tech as +150 underdogs, a $100 bet would profit $150. Had they been -150 favorites instead, you’d need to bet $150 to have a chance at a $100 return.

Louisville Cardinals Props

If you have a favorite Cardinal and want to bet on his stats for the game, look at proposition, or prop, bets. Like over/unders, prop bets are bets on whether more or less of something will happen than the books are expecting.

College football player props are far less common than NFL ones, so make sure to find a sportsbook that offers them.

Louisville Cardinals Futures

You can also bet on a variety of end-of-season results for the Cardinals. These are called futures bets.

Some Cardinals futures bets available include, among others, their odds to win the ACC, win the national title, or go over a certain number of wins for the season. These bets are priced like moneylines to reflect how likely they are to happen.

Next Louisville Game

Game Details
vs Clemson Tigers
Clemson
location pin
Sat 11/1512:30 AM

Louisville vs Clemson Odds

More Odds
SpreadTotalMoneyline
CLEM
+2.5-110
o50.5-115
+110
LOU
-2.5-110
u50.5-110
-130

Cardinals Injuries

All NCAAF Injuries

There are no injuries for this team currently.

Louisville Cardinals Football

The Louisville Cardinals are headed by Coach Jeff Brohm, leading the team to a successful season after just 2 years with the team. The Cardinals finished with a 9-4 record, with a 35-35 win in the Sun Bowl. 

The team will play Eastern Kentucky Colonels on August 30th at the L&N Stadium before taking on the James Madison Dukes.

Louisville Cardinals Point Spreads

Here’s an example of a past Cards game vs. Pittsburgh point spread.

  • Louisville +3 (-110)
  • Pittsburgh -3 (-110)

The Cardinals lost the game, 23-20, making the bet a tie or a push. This means bettors on either side got their money back. For Cardinals bets to have won, they would’ve needed to win the game or lose by one or two points. Pittsburgh backers would have needed a win by four or more for their bets to cash.

Louisville Cardinals Over/Unders

Another popular bet that can be made on college football games is an over/under or total bet. With these bets, neither the winner of the game nor the winning margin matters. Instead, you’re betting on the combined scoring of the teams.

Using their game against Georgia Tech as an example, books set the total at 54. The game finished 39-34 for Tech for a combined 73 points. This was a winner for anyone who bet the over. Had the teams combined for fewer than 63 points, under bets would have cashed; if it landed at exactly 63, both sides would've gotten their stake back.

Louisville Cardinals Moneylines

Another common college football bet is a moneyline bet. Instead of handicapping a team by a certain number of points, oddsmakers adjust the payout based on the chances either team has of winning.

Moneyline bets are easiest to understand if you think in units of $100. Were the Cardinals to defeat Georgia Tech as +150 underdogs, a $100 bet would profit $150. Had they been -150 favorites instead, you’d need to bet $150 to have a chance at a $100 return.

Louisville Cardinals Props

If you have a favorite Cardinal and want to bet on his stats for the game, look at proposition, or prop, bets. Like over/unders, prop bets are bets on whether more or less of something will happen than the books are expecting.

College football player props are far less common than NFL ones, so make sure to find a sportsbook that offers them.

Louisville Cardinals Futures

You can also bet on a variety of end-of-season results for the Cardinals. These are called futures bets.

Some Cardinals futures bets available include, among others, their odds to win the ACC, win the national title, or go over a certain number of wins for the season. These bets are priced like moneylines to reflect how likely they are to happen.