Louisville vs. Pittsburgh Odds & Betting Predictions - September 27, 2025

Louisville at Pittsburgh

4:00 pm • ESPN2
34 - 27

Louisville at Pittsburgh Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Louisville
4-0
-6.5
-6.5-115
o53.5-110
-155
Pittsburgh
2-2
u53.5
+6.5-105
u53.5-110
+130
location pinSaturday 4:00 p.m.
September 27, 2025
Acrisure StadiumPittsburgh
Louisville vs. Pittsburgh Expert Picks
Will Brinson
Will Brinson
Last 30d: 44-39-1 (+1.8u)
LOU -3.5-115
1u
Picks Office
Picks Office
Last 30d: 60-83-3 (-19.6u)
LOU -4.5+100
1u
💰🦡 Jake
💰🦡 Jake
Last 30d: 101-124-6 (+29.5u)
LOU u31.5-130
1.3u
Mjaybrod
Mjaybrod
Last 30d: 67-83-3 (-10.0u)
Under 57.5-110
1u
Dumbbell theory to the max
Boomer Betz
Boomer Betz
Last 30d: 124-107-2 (+20.8u)
LOU -3-110
0.91u

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Prop Odds Comparison

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Line Movement Tracker

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Louisville vs. Pittsburgh Public Betting Percentages

Away Logo

Louisville

Public

51%

Bets%

49%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Pittsburgh
2-22-10-11-10-1
Louisville
1-30-31-01-3N/A

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Pittsburgh
3-13-00-11-11-0
Louisville
3-12-11-03-1N/A

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Pittsburgh
2-2N/AN/A1-10-1
Louisville
4-0N/AN/A4-0N/A

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 13th@WVUL 24-31-7 LU 55.5WVU -275
Sep 6thCMUW 45-17-21.5 WO 48PITT -2000
Aug 30thDUQW 61-9-40.5 WO 58.5-
Dec 26th@TOLL 46-48-6.5 LO 48.5TOL -238
Nov 30th@BCL 23-34+3.5 LO 50.5BC +140
Team Stats
392
Total Yards
339
85
Total Plays
55
4.6117647058823525
Yards Per Play
6.163636363636364
339
YDS
259
33/51
Comps/Atts
17/32
6.647058823529412
YPA
8.09375
3/1
TDs/INTs
2/3
2/20
Sacks/Yards
2/8
53
Rush Yards
80
34
Attempts
23
1.5588235294117647
YPC
3.4782608695652173
1
TDs
0
0
Fumbles Lost
2
1
Interceptions
3
4/4 100%
Redzone
2/3 66.67%
9/19 0%
3rd Down
1/10 0%
0/0 0%
4th Down
1/4 0%
23
Total
14
16
Pass
9
6
Rush
3
1
Penalty
2
9/92
Penalties/Yards
6/38

Louisville vs. Pittsburgh Odds Comparison

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Louisville at Pittsburgh Team Totals

MatchupOverUnder
Louisville
4-0
o28-111
u28-118
Pittsburgh
2-2
o25-114
u25-114