Louisville vs. Pittsburgh Odds & Betting Predictions - September 27, 2025
Louisville at Pittsburgh
4:00 pm • ESPN2Louisville at Pittsburgh Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
---|---|---|---|---|
![]() Louisville 4-0 | -6.5 | -6.5-115 | o53.5-110 | -155 |
![]() Pittsburgh 2-2 | u53.5 | +6.5-105 | u53.5-110 | +130 |

Acrisure StadiumPittsburgh
Louisville vs. Pittsburgh Expert Picks

Will Brinson
Last 30d: 44-39-1 (+1.8u)
LOU -3.5-115
1u

Picks Office
Last 30d: 60-83-3 (-19.6u)
LOU -4.5+100
1u

💰🦡 Jake
Last 30d: 101-124-6 (+29.5u)
LOU u31.5-130
1.3u

Mjaybrod
Last 30d: 67-83-3 (-10.0u)
Under 57.5-110
1u
Dumbbell theory to the max

Boomer Betz
Last 30d: 124-107-2 (+20.8u)
LOU -3-110
0.91u
Louisville vs. Pittsburgh Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Louisville vs. Pittsburgh Public Betting Percentages
Betting Trends
- Pittsburgh are 2-2 in their last 5 games.
- Pittsburgh are 2-2 in their last 5 games against the spread
- Pittsburgh are 0-1 in their road games against the spread
- The totals have gone OVER in 3 of Pittsburgh' last 4 games
- The totals have gone OVER in 3 of Pittsburgh' 3 last games at home
Matchup History
Against the Spread (ATS) History
overall | home | away | favorite | underdog | |
---|---|---|---|---|---|
![]() | 2-2 | 2-1 | 0-1 | 1-1 | 0-1 |
![]() | 1-3 | 0-3 | 1-0 | 1-3 | N/A |
Over/Under History
overall | home o/u | away o/u | favorite o/u | underdog o/u | |
---|---|---|---|---|---|
![]() | 3-1 | 3-0 | 0-1 | 1-1 | 1-0 |
![]() | 3-1 | 2-1 | 1-0 | 3-1 | N/A |
Straight-Up (ML) History
overall | home | away | favorite | underdog | |
---|---|---|---|---|---|
![]() | 2-2 | N/A | N/A | 1-1 | 0-1 |
![]() | 4-0 | N/A | N/A | 4-0 | N/A |
Last 5 Matchups
Team Stats
392
Total Yards
339
85
Total Plays
55
4.6117647058823525
Yards Per Play
6.163636363636364
339
YDS
259
33/51
Comps/Atts
17/32
6.647058823529412
YPA
8.09375
3/1
TDs/INTs
2/3
2/20
Sacks/Yards
2/8
9/92
Penalties/Yards
6/38
Louisville vs. Pittsburgh Odds Comparison
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Louisville at Pittsburgh Team Totals
MatchupOverUnder | ||
---|---|---|
![]() Louisville 4-0 | o28-111 | u28-118 |
![]() Pittsburgh 2-2 | o25-114 | u25-114 |