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Cardinals vs. Panthers Odds & Betting Predictions - September 27, 2025

Cardinals at Panthers

4:00 pm • ESPN2

Louisville Cardinals

8-4
34
34 - 27

Pittsburgh Panthers

8-4
27

Cardinals at Panthers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Cardinals
8-4
-6.5
-6.5-115
o53.5-110
-155
Panthers
8-4
u53.5
+6.5-105
u53.5-110
+130
location pinSaturday 4:00 p.m.
September 27, 2025
Acrisure StadiumPittsburgh
Cardinals vs. Panthers Expert Picks
Will Brinson
Will Brinson
Last 30d: 28-34-2 (+1.4u)
LOU -3.5-115
1u
Picks Office
Picks Office
Last 30d: 213-165-4 (+29.0u)
LOU -4.5+100
1u
💰🦡 Jake
💰🦡 Jake
Last 30d: 97-113-2 (-7.2u)
LOU u31.5-130
1.3u
Mjaybrod
Mjaybrod
Last 30d: 116-110-2 (+6.2u)
Under 57.5-110
1u
Dumbbell theory to the max
Boomer Betz
Boomer Betz
Last 30d: 136-156-6 (-22.5u)
LOU -3-110
0.91u

Cardinals vs. Panthers Previews & Analysis

  • Louisville vs. Pitt: Major Advantages for Cards article feature image

    Louisville vs. Pitt: Major Advantages for Cards

    Action Analytics•
    Sep 27, 2025 UTC
  • Your Week 5 NCAAF Betting Cheat Sheet article feature image

    Your Week 5 NCAAF Betting Cheat Sheet

    Pete Ruden•
    Sep 27, 2025 UTC
  • Oregon vs. Penn State Best Bets & MORE College Football Picks & Parlays | BBOC LIVE article feature image

    Oregon vs. Penn State Best Bets & MORE College Football Picks & Parlays | BBOC LIVE

    Joshua Nunn•
    Sep 26, 2025 UTC
  • Will Alabama vs Georgia Be A SHOOTOUT? | College Football Week 5 Best Bets | BBOC article feature image

    Will Alabama vs Georgia Be A SHOOTOUT? | College Football Week 5 Best Bets | BBOC

    Collin Wilson•
    Sep 26, 2025 UTC
See more NCAAF Coverage Right Arrow

Prop Odds Comparison

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No props found

Line Movement Tracker

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Cardinals vs. Panthers Public Betting Percentages

Away Logo

Cardinals

Public

Home Logo

Panthers

51%

Bets%

49%

Money%

NCAAF Public Betting Right Arrow

Betting Trends

  • Panthers are 3-2 in their last 5 games.
  • Panthers are 3-2 in their last 5 games against the spread
  • Panthers are 4-1 in their road games against the spread
  • The totals have gone OVER in 2 of Panthers' last 5 games
  • The totals have gone OVER in 5 of Panthers' 7 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Panthers		8-44-34-15-12-3
Cardinals		4-81-73-12-72-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Panthers		8-45-23-24-23-2
Cardinals		5-74-41-35-40-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Panthers		8-4N/AN/A5-12-3
Cardinals		8-4N/AN/A6-32-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 13th@WVUL 24-31-7 LU 55.5WVU -275
Sep 6thCMUW 45-17-21.5 WO 48PITT -2000
Aug 30thDUQW 61-9-40.5 WO 58.5-
Dec 26th@TOLL 46-48-6.5 LO 48.5TOL -238
Nov 30th@BCL 23-34+3.5 LO 50.5BC +140
Team Stats

Total

392
Total Yards
339
85
Total Plays
55
4.6117647058823525
Yards Per Play
6.163636363636364

Passing

339
YDS
259
33/51
Comps/Atts
17/32
6.647058823529412
YPA
8.09375
3/1
TDs/INTs
2/3
2/20
Sacks/Yards
2/8

Rushing

53
Rush Yards
80
34
Attempts
23
1.5588235294117647
YPC
3.4782608695652173
1
TDs
0

Turnovers

0
Fumbles Lost
2
1
Interceptions
3

Efficiency

4/4 100%
Redzone
2/3 66.67%
9/19 0%
3rd Down
1/10 0%
0/0 0%
4th Down
1/4 0%

First Downs

23
Total
14
16
Pass
9
6
Rush
3
1
Penalty
2

Misc

9/92
Penalties/Yards
6/38

Cardinals vs. Panthers Odds Comparison

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Cardinals at Panthers Team Totals

MatchupOverUnder
Cardinals
8-4
o28-111
u28-118
Panthers
8-4
o25-114
u25-114