The San Francisco 49ers (6-4) and Arizona Cardinals (3-6) meet in Week 11 on Sunday, Nov. 16. Kickoff is set for 4:05 p.m. ET from State Farm Stadium in Glendale, Ariz. The game will broadcast on FOX.
The 49ers are 3-point favorites over the Cardinals on the spread (49ers -3); the over/under is 48.5. San Francisco is a -165 moneyline favorite while Arizona is +140 to pull off the upset.
Let's get into my 49ers vs Cardinals prediction for today's NFC West game.
49ers vs Cardinals Prediction
- 49ers vs Cardinals pick: Cardinals Moneyline (+135)
My 49ers vs Cardinals best bet is on Arizona moneyline. Find the best odds by checking our live NFL odds page.
49ers vs Cardinals Odds
| 49ers Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-3 -110 | 48.5 -110o / -110u | -165 |
| Cardinals Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+3 -110 | 48.5 -110o / -110u | +140 |
49ers vs Cardinals Week 11 Preview
The Cardinals won’t have Marvin Harrison Jr. in this game because of appendicitis, which will make them pretty one-dimensional on offense.
Trey McBride will probably be the focus of their offensive attack. I think we'll see Greg Dortch pick up the slack for Harrison in this spot as well, and I think this 49ers defense is the worse of the two units.
The Cardinals are at home in this spot, and they've had some really bad luck recently — such as giving up two fumble return touchdowns to the same player last week against Seattle on nearly identical plays.
Remember, the Cardinals hadn't lost a game by more than four points this season before their loss to the Seahawks on Sunday. They've played better than their record indicates.
With San Francisco on the road, this feels more like a coin-flip game between two flawed teams.
Jacoby Brissett has been playing solid football since taking over for Kyler Murray, and although Mac Jones looked good last week, this 49ers defense simply isn’t getting it done.
49ers vs Cardinals Prediction, Betting Analysis
The Cardinals should be able to move the ball one way or another throughout this game.
A few weeks back, Arizona held that mighty Cowboys offense in check at home, and then had some really bad luck against Seattle the following game.
On Sunday against Seattle, it wasn’t like Sam Donald had a great day; he lost a fumble and threw a pick, and efficiency-wise, it wasn’t close to his best performance.
The Cardinals defense might be a little underrated in this spot.
Arizona is banged up, for sure. Will Johnson, Max Melton, Darius Robinson, and Walter Nolen are all dealing with injuries — but if the Cardinals can get some of those guys back, this becomes a much more even matchup.
Pick: Cardinals Moneyline (+135)
Spread
I'm not betting either side of the spread in this contest.
Moneyline
My Cardinals vs 49ers betting prediction is on Arizona to win outright on the moneyline.
Over/Under
I have no bet on the game total.
