Northwestern vs. USC Odds & Betting Predictions - November 8, 2025

Northwestern at USC

2:00 am • FOX

Northwestern Wildcats

7-6

17 - 38

USC Trojans

9-4

MatchupOpenSpreadTotalMoneyline
Northwestern 7-6	+16.5	+14.5-112	o54.5-108	+472
USC 9-4	u51.5	-14.5-108	u54.5-111	-662

Saturday 2:00 a.m.

November 08, 2025

Los Angeles Memorial ColiseumLos Angeles

USC o33.5 Team Total-125

C.Komolafe o72.5 Rush Yds-114

NW +14.5-110

X: PicksOffice

USC -14-112

USC o16.5 Team Total (1H)-125

Over 50.5-118

0.85u

NW +17-130

1.3u

NW +17-130

Under 26.5 (1H)-105

1.58u

Over 51-110

G.Wilde o3.5 Recs-125

0.5u

Over 51-110

NW +14.5-105

1.05u

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NCAAF Public Betting

USC are 4-1 in their last 5 games.
USC are 3-2 in their last 5 games against the spread
USC are 1-4 in their road games against the spread
The totals have gone OVER in 3 of USC' last 5 games
The totals have gone OVER in 4 of USC' 7 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
USC	5-7	4-3	1-4	4-6	1-1
Northwestern	6-4-2	5-2	1-2-2	3-2	3-2-2

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
USC	6-6	4-3	2-3	5-5	1-1
Northwestern	5-6-1	3-3-1	2-3	2-2-1	3-4

Straight-Up (ML) History

	overall	home	away	favorite	underdog
USC	9-3	N/A	N/A	9-1	0-2
Northwestern	6-6	N/A	N/A	5-0	1-6

date	opponent	score	spread	over/under	moneyline
Nov 1st	@NEB	W 21-17	-4.5 L	U 59.5	USC -200
Oct 18th	@ND	L 24-34	+10.5 W	U 60.5	ND +300
Oct 11th	MICH	W 31-13	-3 W	U 58.5	USC -160
Sep 27th	@ILL	L 32-34	-6.5 L	O 62	ILL -250
Sep 21st	MSU	W 45-31	-18.5 L	O 55.5	USC -950

Northwestern

Total

USC

280

Total Yards

482

Total Plays

5.090909090909091

Yards Per Play

7.53125

Northwestern

Passing

USC

150

YDS

309

20/30

Comps/Atts

25/34

YPA

9.088235294117647

1/0

TDs/INTs

2/1

2/15

Sacks/Yards

1/9

Northwestern

Rushing

USC

130

Rush Yards

173

Attempts

5.2

YPC

5.766666666666667

TDs

Northwestern

Turnovers

USC

Fumbles Lost

Interceptions

Northwestern

Efficiency

USC

3/3 100%

Redzone

6/6 100%

4/12 0%

3rd Down

6/11 0%

1/2 0%

4th Down

2/2 0%

Northwestern

First Downs

USC

Total

Pass

Rush

Penalty

Northwestern

Misc

USC

2/26

Penalties/Yards

4/30

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MatchupOverUnder
Northwestern 7-6	N/A	N/A
USC 9-4	N/A	N/A

Northwestern vs. USC Odds & Betting Predictions - November 8, 2025

Northwestern at USC

Northwestern Wildcats

USC Trojans

Northwestern at USC Odds

Spread, Total, Moneyline

Northwestern vs. USC Previews & Analysis

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Prop Odds Comparison

Line Movement Tracker

Northwestern vs. USC Public Betting Percentages

Northwestern

Public

USC

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

Northwestern vs. USC Odds Comparison

Northwestern at USC Team Totals