USC vs. Illinois Odds & Betting Predictions - September 27, 2025

USC at Illinois

4:00 pm • FOX
32 - 34

USC at Illinois Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
USC
4-1
-1.5
-6.5-115
o62-110
-250
Illinois
4-1
u56.5
+6.5-108
u62-110
+200
location pinSaturday 4:00 p.m.
September 27, 2025
Memorial Stadium (Champaign, IL)Champaign
USC vs. Illinois Expert Picks
Sandy Plashkes
Sandy Plashkes
Last 30d: 74-104-3 (-10.5u)
USC +120 (Live)
1u
Collin Wilson
Collin Wilson
Last 30d: 86-59-3 (+13.9u)
USC +3 (Live)-110
0.5u
Mjaybrod
Mjaybrod
Last 30d: 68-84-3 (-10.1u)
USC -3.5 (Live)-108
1u
Easy bet here
VegasIsMyBitch
VegasIsMyBitch
Last 30d: 9-14-0 (-3.0u)
Over 62-109
0.46u
Jeremiah Rose
Jeremiah Rose
Last 30d: 34-38-1 (-2.4u)
ILL +7-115
0.35u
Collin Wilson
Collin Wilson
Last 30d: 86-59-3 (+13.9u)
ILL +7-115
1u
Coming back live on USC with a slow start
Sandy Plashkes
Sandy Plashkes
Last 30d: 74-104-3 (-10.5u)
USC -6.5-115
1.15u
Ryan Sura
Ryan Sura
Last 30d: 99-94-2 (+7.7u)
ILL +3.5 (1H)-115
1u
The Degenerates
The Degenerates
Last 30d: 72-62-2 (+4.9u)
ILL +6.5-105
1u
Dan Gaspar
Dan Gaspar
Last 30d: 21-23-7 (-4.0u)
K.Feagin u0.5 Recs+140
1u
Moneyline Hacks
Moneyline Hacks
Last 30d: 118-133-5 (+48.7u)
J.Maiava o8.5 Rush Yds-114
1u
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Babs .
Babs .
Last 30d: 79-70-1 (+8.9u)
Under 61.5-115
1u

USC vs. Illinois Previews & Analysis

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    Player Prop Picks for Allar, Simpson, More

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    Sep 27, 2025 UTC
  • USC vs. Illinois: Back the Road Favorite article feature image

    USC vs. Illinois: Back the Road Favorite

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    Sep 27, 2025 UTC
  • Our NCAAF Best Bets for Saturday's Noon Games article feature image

    Our NCAAF Best Bets for Saturday's Noon Games

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    Sep 27, 2025 UTC
  • Your Week 5 NCAAF Betting Cheat Sheet article feature image

    Your Week 5 NCAAF Betting Cheat Sheet

    Pete Ruden
    Sep 27, 2025 UTC
See more NCAAF Coverage Right Arrow

Prop Odds Comparison

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Line Movement Tracker

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USC vs. Illinois Public Betting Percentages

Away Logo

USC

Public

61%

Bets%

39%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Illinois
4-13-01-12-01-1
USC
2-32-10-22-3N/A

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Illinois
3-21-22-01-12-0
USC
4-13-01-14-1N/A

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Illinois
4-1N/AN/A2-01-1
USC
4-1N/AN/A4-1N/A

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 20th@IUL 10-63+6.5 LO 51.5IU +200
Sep 13thWMUW 38-0-27.5 WU 50.5ILL -6500
Sep 6th@DUKEW 45-19-2.5 WO 49ILL -134
Aug 29thWILW 52-3-48.5 WU 62.5-
Dec 31stSCW 21-17+9.5 WU 50.5ILL +280
Team Stats
490
Total Yards
502
77
Total Plays
62
6.363636363636363
Yards Per Play
8.096774193548388
364
YDS
331
30/43
Comps/Atts
21/27
8.465116279069768
YPA
12.25925925925926
2/1
TDs/INTs
3/0
1/10
Sacks/Yards
1/8
126
Rush Yards
171
34
Attempts
35
3.7058823529411766
YPC
4.885714285714286
2
TDs
1

Turnovers

1
Fumbles Lost
2
1
Interceptions
0

Efficiency

5/5 100%
Redzone
2/4 50%
8/14 0%
3rd Down
6/10 0%
4/5 0%
4th Down
1/1 0%

First Downs

29
Total
25
21
Pass
13
7
Rush
8
1
Penalty
4
8/69
Penalties/Yards
5/42

USC vs. Illinois Odds Comparison

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USC at Illinois Team Totals

MatchupOverUnder
USC
4-1
o34.5-114
u34.5-114
Illinois
4-1
o27.5-114
u27.5-108