USC vs. Illinois Odds & Betting Predictions - September 27, 2025

USC at Illinois

4:00 pm • FOX

USC Trojans

5-2

32 - 34

Illinois Fighting Illini

5-3

MatchupOpenSpreadTotalMoneyline
USC 5-2	-1.5	-6.5-115	o62-110	-250
Illinois 5-3	u56.5	+6.5-108	u62-110	+200

Saturday 4:00 p.m.

September 27, 2025

Gies Memorial Stadium (Champaign, IL)Champaign

USC +120 (Live)

USC +3 (Live)-110

0.5u

USC -3.5 (Live)-108

Easy bet here

Over 62-109

0.46u

ILL +7-115

0.35u

ILL +7-115

Coming back live on USC with a slow start

USC -6.5-115

1.15u

ILL +3.5 (1H)-115

ILL +6.5-105

K.Feagin u0.5 Recs+140

J.Maiava o8.5 Rush Yds-114

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Under 61.5-115

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No props found

NCAAF Public Betting

Illinois are 4-1 in their last 5 games.
Illinois are 4-1 in their last 5 games against the spread
Illinois are 2-2 in their road games against the spread
The totals have gone OVER in 3 of Illinois' last 5 games
The totals have gone OVER in 1 of Illinois' 4 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Illinois	5-3	3-1	2-2	3-0	1-3
USC	4-3	3-1	1-2	3-3	1-0

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Illinois	5-3	1-3	4-0	2-1	3-1
USC	4-3	3-1	1-2	4-2	0-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Illinois	5-3	N/A	N/A	3-0	1-3
USC	5-2	N/A	N/A	5-1	0-1

date	opponent	score	spread	over/under	moneyline
Sep 20th	@IU	L 10-63	+6.5 L	O 51.5	IU +200
Sep 13th	WMU	W 38-0	-27.5 W	U 50.5	ILL -6500
Sep 6th	@DUKE	W 45-19	-2.5 W	O 49	ILL -134
Aug 29th	WIL	W 52-3	-48.5 W	U 62.5	-
Dec 31st	SC	W 21-17	+9.5 W	U 50.5	ILL +280

USC

Total

Illinois

490

Total Yards

502

Total Plays

6.363636363636363

Yards Per Play

8.096774193548388

USC

Passing

Illinois

364

YDS

331

30/43

Comps/Atts

21/27

8.465116279069768

YPA

12.25925925925926

2/1

TDs/INTs

3/0

1/10

Sacks/Yards

1/8

USC

Rushing

Illinois

126

Rush Yards

171

Attempts

3.7058823529411766

YPC

4.885714285714286

TDs

USC

Turnovers

Illinois

Fumbles Lost

Interceptions

USC

Efficiency

Illinois

5/5 100%

Redzone

2/4 50%

8/14 0%

3rd Down

6/10 0%

4/5 0%

4th Down

1/1 0%

USC

First Downs

Illinois

Total

Pass

Rush

Penalty

USC

Misc

Illinois

8/69

Penalties/Yards

5/42

Could not load odds

See more NCAAF Odds

MatchupOverUnder
USC 5-2	o34.5-114	u34.5-114
Illinois 5-3	o27.5-114	u27.5-108

USC vs. Illinois Odds & Betting Predictions - September 27, 2025

USC at Illinois

USC Trojans

Illinois Fighting Illini

USC at Illinois Odds

Spread, Total, Moneyline

USC vs. Illinois Previews & Analysis

Player Prop Picks for Allar, Simpson, More

USC vs. Illinois: Back the Road Favorite

Our NCAAF Best Bets for Saturday's Noon Games

Your Week 5 NCAAF Betting Cheat Sheet

Prop Odds Comparison

Line Movement Tracker

USC vs. Illinois Public Betting Percentages

USC

Public

Illinois

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

USC vs. Illinois Odds Comparison

USC at Illinois Team Totals