Michigan St vs. USC Odds & Betting Predictions - September 21, 2025

Michigan St at USC

3:00 am • FOX

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Michigan State Spartans

@

USC Trojans

MatchupOpenSpreadTotalMoneyline
Michigan St 3-0	+14.5	+18.5-115	o56.5-105	+600
USC 3-0	u56.5	-18.5-105	u56.5-115	-950

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Sunday 3:00 a.m.

September 21, 2025

Los Angeles Memorial ColiseumLos Angeles

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74°Fahrenheit

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0%Rain

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3Wind

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NCAAF Public Betting

USC are 3-0 in their last 5 games.
USC are 2-1 in their last 5 games against the spread
USC are 0-1 in their road games against the spread
The totals have gone OVER in 2 of USC' last 3 games
The totals have gone OVER in 2 of USC' 2 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
USC	2-1	2-0	0-1	2-1	N/A
Michigan St	0-3	0-3	N/A	0-3	N/A

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
USC	2-1	2-0	0-1	2-1	N/A
Michigan St	2-1	2-1	N/A	2-1	N/A

Straight-Up (ML) History

	overall	home	away	favorite	underdog
USC	3-0	N/A	N/A	3-0	N/A
Michigan St	3-0	N/A	N/A	3-0	N/A

date	opponent	score	spread	over/under	moneyline
Sep 13th	@PUR	W 33-17	-20.5 L	U 59.5	USC -1600
Sep 6th	GASO	W 59-20	-29 W	O 62.5	USC -7000
Aug 30th	MOST	W 73-13	-36.5 W	O 60	USC -9000
Dec 28th	TA&M	W 35-31	-	-	-
Nov 30th	ND	L 35-49	+7 L	O 52.5	ND +207

Total

Passing

656

YDS

1092

58/82

Comps/Atts

61/85

8

YPA

12.85

6/2

TDs/INTs

7/0

8/64

Sacks/Yards

2/14

Rushing

504

Rush Yards

720

112

Attempts

103

4.5

YPC

6.99

7

TDs

12

Turnovers

Fumbles Lost

2

Interceptions

0

Efficiency

13/14 92.9%

Redzone

17/18 94.4%

15/35 0%

3rd Down

15/29 0%

3/5 0%

4th Down

4/4 0%

First Downs

64

Total

77

33

Pass

40

24

Rush

29

7

Penalty

8

Misc

/

Penalties/Yards

/

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MatchupOverUnder
Michigan St 3-0	N/A	N/A
USC 3-0	N/A	N/A