Michigan St vs. USC Odds & Betting Predictions - September 21, 2025
Michigan St at USC
3:00 am • FOXMichigan St at USC Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 Michigan St 4-8 | +14.5 | +18.5-114 | o55.5-110 | +625 |
 USC 9-4 | u56.5 | -18.5-106 | u55.5-110 | -950 |
Los Angeles Memorial ColiseumLos Angeles
Michigan St vs. USC Expert Picks
Ryan Minion
Last 30d: 226-259-4 (+28.6u)
USC -18.5-110
$1.10
YBK Picks.com
Last 30d: 14-12-0 (+1.5u)
USC -19.5-105
3u
Will Brinson
Last 30d: 2-17-0 (-10.0u)
USC -18.5-110
1.1u
Mike McNamara
Last 30d: 57-91-1 (-6.2u)
Over 55-110
0.2u
Full Preview on Action Network.
Picks Office
Last 30d: 215-140-2 (+61.9u)
USC -18-110
1u
John Feltman
Last 30d: 54-55-3 (-10.3u)
USC o37.5 Team Total-115
3u
💰🦡 Jake
Last 30d: 105-107-3 (+25.6u)
MSU +10.5 (1H)+100
1u
Ryan Minion
Last 30d: 226-259-4 (+28.6u)
USC -10 (1H)-110
$1.00
Big Bets On Campus (CFB)
Last 30d: 5-3-1 (+1.8u)
USC o36.5 Team Total-120
0.83u
@_Collin1 https://myaction.app/V2FMmqguNWb
USC -10 (1H)-110
0.91u
@Stuckey2 https://myaction.app/V2FMmqguNWb
Collin Wilson
Last 30d: 4-7-1 (-2.1u)
USC o37.5 Team Total-114
1u
Massive EPA edge to USC offense, also top 10 Quality and Finishing Drives.
Boomer Betz
Last 30d: 82-85-0 (-14.2u)
MSU +17.5-102
0.98u
Doug Ziefel
Last 30d: 133-143-1 (+8.0u)
Under 56.5-105
0.53u
Michigan St vs. USC Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Michigan St vs. USC Public Betting Percentages
Betting Trends
- USC are 4-1 in their last 5 games.
- USC are 3-2 in their last 5 games against the spread
- USC are 1-4 in their road games against the spread
- The totals have gone OVER in 3 of USC' last 5 games
- The totals have gone OVER in 4 of USC' 7 last games at home
Matchup History
Against the Spread (ATS) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 5-7 | 4-3 | 1-4 | 4-6 | 1-1 |
| 7-5 | 1-5 | 5-0 | 1-4 | 6-1 |
Over/Under History
| overall | home o/u | away o/u | favorite o/u | underdog o/u | |
|---|---|---|---|---|---|
| 6-6 | 4-3 | 2-3 | 5-5 | 1-1 |
| 7-5 | 3-3 | 3-2 | 3-2 | 4-3 |
Straight-Up (ML) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 9-3 | N/A | N/A | 9-1 | 0-2 |
| 4-8 | N/A | N/A | 4-1 | 0-7 |
Last 5 Matchups
Team Stats
225
YDS
234
13/23
Comps/Atts
20/26
9.782608695652174
YPA
9
3/0
TDs/INTs
3/0
2/7
Sacks/Yards
0/0
6/54
Penalties/Yards
9/78
Michigan St vs. USC Odds Comparison
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Michigan St at USC Team Totals
MatchupOverUnder | ||
|---|---|---|
Michigan St 4-8 | N/A | N/A |
USC 9-4 | N/A | N/A |