USC vs. Notre Dame Odds & Betting Predictions - October 18, 2025
USC at Notre Dame
11:30 pm • NBCUSC at Notre Dame Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
---|---|---|---|---|
![]() USC 5-1 | +10.5 | +9.5-110 | o61.5-110 | +270 |
![]() Notre Dame 4-2 | u53.5 | -9.5-110 | u61.5-110 | -335 |

Notre Dame StadiumSouth Bend
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USC vs. Notre Dame Expert Picks

Collin Wilson
Last 30d: 83-65-1 (+6.1u)
J.Price o61.5 Rush Yds-114
0.57u
Full writeup Action Network. Zone read efficiency poor for USC defense. Price best inside/outside rusher in Irish backfield by yards per carry. Averaging 70.3 rushing yards per game
ND o35.5 Team Total-105
1.05u
Full Writeup coming Action Network. Side is inflated w USC injuries on offense. Notre Dame extreme advantages in run concepts. Heavy rain expected early making a sloppy track
USC vs. Notre Dame Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
USC vs. Notre Dame Public Betting Percentages
Betting Trends
- Notre Dame are 3-2 in their last 5 games.
- Notre Dame are 3-2 in their last 5 games against the spread
- Notre Dame are 1-1 in their road games against the spread
- The totals have gone OVER in 4 of Notre Dame' last 5 games
- The totals have gone OVER in 2 of Notre Dame' 4 last games at home
Matchup History
Against the Spread (ATS) History
overall | home | away | favorite | underdog | |
---|---|---|---|---|---|
![]() | 3-3 | 2-2 | 1-1 | 3-3 | N/A |
![]() | 3-3 | 3-1 | 0-2 | 3-3 | N/A |
Over/Under History
overall | home o/u | away o/u | favorite o/u | underdog o/u | |
---|---|---|---|---|---|
![]() | 4-2 | 2-2 | 2-0 | 4-2 | N/A |
![]() | 4-2 | 3-1 | 1-1 | 4-2 | N/A |
Straight-Up (ML) History
overall | home | away | favorite | underdog | |
---|---|---|---|---|---|
![]() | 4-2 | N/A | N/A | 4-2 | N/A |
![]() | 5-1 | N/A | N/A | 5-1 | N/A |
Last 5 Matchups
Team Stats
1955
YDS
1757
136/186
Comps/Atts
114/169
10.51
YPA
10.4
14/2
TDs/INTs
13/3
4/28
Sacks/Yards
9/74
/
Penalties/Yards
/
USC vs. Notre Dame Odds Comparison
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USC at Notre Dame Team Totals
MatchupOverUnder | ||
---|---|---|
![]() USC 5-1 | N/A | N/A |
![]() Notre Dame 4-2 | N/A | N/A |