Rams vs. Cardinals Odds & Betting Predictions - December 7, 2025
Rams at Cardinals
9:25 pm • FOXRams at Cardinals Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 Rams 10-3 | -9.5 | -9.5-110 | o49.5-110 | -510 |
 Cardinals 3-10 | u49.5 | +9.5-110 | u49.5-110 | +372 |
State Farm StadiumGlendale
Rams vs. Cardinals Expert Picks
Jeremiah Rose
Last 30d: 43-42-1 (-0.7u)
LA -5.5 (Live)-115
0.35u
Boyd / FanDuel
Lock & Cash
Last 30d: 13-14-2 (-2.5u)
ARI +9.5-110
1.5u
YBK Picks.com
Last 30d: 40-34-1 (+7.1u)
LA -9.5-105
1.9u
Chris Gimino
Last 30d: 28-25-0 (+2.7u)
E.Higgins 3+ Receptions Yes+179
1u
J.Brissett u38.5 Pass Att-115
1u
Sean Zerillo
Last 30d: 89-79-1 (+6.5u)
LA -9-112
0.25u
Babs .
Last 30d: 131-96-1 (+20.9u)
K.Williams u66.5 Rush Yds-122
1u
Nick Giffen
Last 30d: 53-80-1 (+9.0u)
Highest Scoring Game on Sunday: LAR/ARI+450
0.25u
Brandon Anderson
Last 30d: 49-133-2 (-3.8u)
LA -26.5+800
0.8u
The Cardinals have a bevy of close losses this season and have mostly been competitive despite the 3-9 record, but Arizona also lost by 19 and 22 to the 49ers and Seahawks in November. Might it be time to complete the division trifecta?
The Rams need to get back on track after a shocking loss to Carolina, but don't let that loss throw you off the scent. LA was mostly dominant in that one outside a handful of huge swing plays, with a huge 61-to-39% Success Rate advantage.
This might be just the matchup for Los Angeles to get back on track.
The Rams have won 14 of the last 17 against the Cardinals, and only one of those 17 games was closer than seven points. Eight of those 14 Rams wins came by at least 17 points, and that includes wins by 22, 23, 23, 27, 33, and 34 — almost half of them by 22 or more!
The Cardinals offense has been worse early in games, and their defense is trending down as the season goes along. That's a bad script for Arizona and the game could get away quickly in what looks like a nice bounce-back MVP spot for Matthew Stafford too.
The Rams already have five wins this season by 14 or more points, including wins by 24, 27, and 28.
I'll skip the traditional line and go straight for the alternates: Rams -13.5 at +165, Rams -16.5 at +240, and Rams -20.5 at +425 (bet365).
We're not done! In case this really gets away from Arizona, sprinkle Rams -26.5 at +800 and Rams -30.5 at +1300 too (FanDuel).
LA -30.5+1300
0.1u
The Cardinals have a bevy of close losses this season and have mostly been competitive despite the 3-9 record, but Arizona also lost by 19 and 22 to the 49ers and Seahawks in November. Might it be time to complete the division trifecta?
The Rams need to get back on track after a shocking loss to Carolina, but don't let that loss throw you off the scent. LA was mostly dominant in that one outside a handful of huge swing plays, with a huge 61-to-39% Success Rate advantage.
This might be just the matchup for Los Angeles to get back on track.
The Rams have won 14 of the last 17 against the Cardinals, and only one of those 17 games was closer than seven points. Eight of those 14 Rams wins came by at least 17 points, and that includes wins by 22, 23, 23, 27, 33, and 34 — almost half of them by 22 or more!
The Cardinals offense has been worse early in games, and their defense is trending down as the season goes along. That's a bad script for Arizona and the game could get away quickly in what looks like a nice bounce-back MVP spot for Matthew Stafford too.
The Rams already have five wins this season by 14 or more points, including wins by 24, 27, and 28.
I'll skip the traditional line and go straight for the alternates: Rams -13.5 at +165, Rams -16.5 at +240, and Rams -20.5 at +425 (bet365).
We're not done! In case this really gets away from Arizona, sprinkle Rams -26.5 at +800 and Rams -30.5 at +1300 too (FanDuel).
LA -13.5+165
0.41u
The Cardinals have a bevy of close losses this season and have mostly been competitive despite the 3-9 record, but Arizona also lost by 19 and 22 to the 49ers and Seahawks in November. Might it be time to complete the division trifecta?
The Rams need to get back on track after a shocking loss to Carolina, but don't let that loss throw you off the scent. LA was mostly dominant in that one outside a handful of huge swing plays, with a huge 61-to-39% Success Rate advantage.
This might be just the matchup for Los Angeles to get back on track.
The Rams have won 14 of the last 17 against the Cardinals, and only one of those 17 games was closer than seven points. Eight of those 14 Rams wins came by at least 17 points, and that includes wins by 22, 23, 23, 27, 33, and 34 — almost half of them by 22 or more!
The Cardinals offense has been worse early in games, and their defense is trending down as the season goes along. That's a bad script for Arizona and the game could get away quickly in what looks like a nice bounce-back MVP spot for Matthew Stafford too.
The Rams already have five wins this season by 14 or more points, including wins by 24, 27, and 28.
I'll skip the traditional line and go straight for the alternates: Rams -13.5 at +165, Rams -16.5 at +240, and Rams -20.5 at +425 (bet365).
We're not done! In case this really gets away from Arizona, sprinkle Rams -26.5 at +800 and Rams -30.5 at +1300 too (FanDuel).
LA -16.5+240
0.6u
The Cardinals have a bevy of close losses this season and have mostly been competitive despite the 3-9 record, but Arizona also lost by 19 and 22 to the 49ers and Seahawks in November. Might it be time to complete the division trifecta?
The Rams need to get back on track after a shocking loss to Carolina, but don't let that loss throw you off the scent. LA was mostly dominant in that one outside a handful of huge swing plays, with a huge 61-to-39% Success Rate advantage.
This might be just the matchup for Los Angeles to get back on track.
The Rams have won 14 of the last 17 against the Cardinals, and only one of those 17 games was closer than seven points. Eight of those 14 Rams wins came by at least 17 points, and that includes wins by 22, 23, 23, 27, 33, and 34 — almost half of them by 22 or more!
The Cardinals offense has been worse early in games, and their defense is trending down as the season goes along. That's a bad script for Arizona and the game could get away quickly in what looks like a nice bounce-back MVP spot for Matthew Stafford too.
The Rams already have five wins this season by 14 or more points, including wins by 24, 27, and 28.
I'll skip the traditional line and go straight for the alternates: Rams -13.5 at +165, Rams -16.5 at +240, and Rams -20.5 at +425 (bet365).
We're not done! In case this really gets away from Arizona, sprinkle Rams -26.5 at +800 and Rams -30.5 at +1300 too (FanDuel).
LA -20.5+425
1.06u
The Cardinals have a bevy of close losses this season and have mostly been competitive despite the 3-9 record, but Arizona also lost by 19 and 22 to the 49ers and Seahawks in November. Might it be time to complete the division trifecta?
The Rams need to get back on track after a shocking loss to Carolina, but don't let that loss throw you off the scent. LA was mostly dominant in that one outside a handful of huge swing plays, with a huge 61-to-39% Success Rate advantage.
This might be just the matchup for Los Angeles to get back on track.
The Rams have won 14 of the last 17 against the Cardinals, and only one of those 17 games was closer than seven points. Eight of those 14 Rams wins came by at least 17 points, and that includes wins by 22, 23, 23, 27, 33, and 34 — almost half of them by 22 or more!
The Cardinals offense has been worse early in games, and their defense is trending down as the season goes along. That's a bad script for Arizona and the game could get away quickly in what looks like a nice bounce-back MVP spot for Matthew Stafford too.
The Rams already have five wins this season by 14 or more points, including wins by 24, 27, and 28.
I'll skip the traditional line and go straight for the alternates: Rams -13.5 at +165, Rams -16.5 at +240, and Rams -20.5 at +425 (bet365).
We're not done! In case this really gets away from Arizona, sprinkle Rams -26.5 at +800 and Rams -30.5 at +1300 too (FanDuel).
Moneyline Hacks
Last 30d: 159-142-3 (+48.6u)
ARI +8.5-111
1u
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Grant Neiffer
Last 30d: 31-94-9 (-13.7u)
K.Williams Anytime TD Scorer Yes+105
0.53u
Action Pod NFL Picks
Last 30d: 65-152-3 (-12.6u)
LA -20.5+425
1.02u
@wheatonbrando https://myaction.app/6T0qetUiRYb
LA -26.5+800
1.04u
@wheatonbrando https://myaction.app/6T0qetUiRYb
LA -30.5+1300
0.1u
@wheatonbrando https://myaction.app/6T0qetUiRYb
LA -13.5+168
1.01u
@wheatonbrando https://myaction.app/6T0qetUiRYb
LA -16.5+240
1.01u
@wheatonbrando https://myaction.app/6T0qetUiRYb
Chris Raybon
Last 30d: 19-16-2 (+8.8u)
M.Wilson Anytime TD Scorer Yes+220
2.2u
TAN Pod Touchdown Show
Last 30d: 39-118-3 (+1.6u)
T.McBride Anytime TD Scorer Yes+150
0.5u
@GDAWG5000 https://myaction.app/vlYW83GcRYb
T.Ferguson Anytime TD Scorer Yes+1000
0.5u
@GDAWG5000 https://myaction.app/vlYW83GcRYb
Boomer Betz
Last 30d: 138-158-5 (-22.3u)
J.Brissett u259.5 Pass Yds-115
1.73u
Action Pod NFL Picks
Last 30d: 65-152-3 (-12.6u)
M.Wilson Anytime TD Scorer Yes+200
1u
@Stuckey2 https://myaction.app/bLFYwq6hPYb
Roger Goodell
Last 30d: 46-58-1 (-8.6u)
ARI +8.5-115
1u
FTN Fantasy
Last 30d: 114-158-3 (-56.9u)
LA -7.5-110
0.91u
Rams vs. Cardinals Previews & Analysis
Rams vs. Cardinals Props
Prop Projections
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Prop Odds Comparison
Line Movement Tracker
Rams vs. Cardinals Public Betting Percentages
Betting Trends
- Cardinals are 1-4 in their last 5 games.
- Cardinals are 3-2 in their last 5 games against the spread
- Cardinals are 5-1 in their road games against the spread
- The totals have gone OVER in 2 of Cardinals' last 5 games
- The totals have gone OVER in 6 of Cardinals' 7 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Rams vs. Cardinals Injury Updates
Rams Injuries
- Tyler HigbeeTE
Higbee is out with ankle
Out
Cardinals Injuries
- Zay JonesWR
Jones is out with achilles
Out
- James ConnerRB
Conner is out with foot
Out
- Greg DortchWR
Dortch is out with chest
Out
- Kyler MurrayQB
Murray is out with foot
Out
- Emari DemercadoRB
Demercado is out with ankle
Out
- Marvin HarrisonWR
Harrison is out with heel
Out
- Trey BensonRB
Benson is out with knee
Out
- Tip ReimanTE
Reiman is out with ankle
Out
- Xavier WeaverWR
Weaver is out with hamstring
Out
Team Stats
Rams vs. Cardinals Odds Comparison
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Rams at Cardinals Team Totals
MatchupOverUnder | ||
|---|---|---|
Rams 10-3 | N/A | N/A |
Cardinals 3-10 | N/A | N/A |