Chiefs vs. Giants Odds & Betting Predictions - September 22, 2025

Chiefs at Giants

12:20 am • NBC
22 - 9

Chiefs at Giants Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Chiefs
2-3
-6.5
-6-115
o44.5-110
-320
Giants
1-4
u42.5
+6-105
u44.5-110
+245
location pinMonday 12:20 a.m.
September 22, 2025
MetLife StadiumEast Rutherford
Chiefs vs. Giants Expert Picks
Boomer Betz
Boomer Betz
Last 30d: 132-115-2 (+28.5u)
NYG +10 (Live)-122
0.5u
Can i middle?
Collin Wilson
Collin Wilson
Last 30d: 81-63-1 (+3.3u)
NYG +9.5 (Live)-102
1.02u
Mjaybrod
Mjaybrod
Last 30d: 76-84-3 (+0.3u)
C.Skattebo First Touchdown Scorer Yes+950
2.38u
Skat pack
Kyle Murray
Kyle Murray
Last 30d: 61-51-2 (+13.4u)
KC -5.5-115
1u
Chris Raybon
Chris Raybon
Last 30d: 24-33-1 (+7.4u)
J.Royals Anytime TD Scorer Yes+1500
0.5u
Worthy, Rice, Pacheco, CEH, Hunt, Tyreek among rookies to score TD in first career game w/ KC
Vegas Refund
Vegas Refund
Last 30d: 36-33-2 (-0.1u)
NYG +6-105
1.05u
Kyle Murray
Kyle Murray
Last 30d: 61-51-2 (+13.4u)
P.Mahomes o22.5 Pass Comp-110
1u
M.Nabers o75.5 Rec Yds-118
1.18u
Chris Raybon
Chris Raybon
Last 30d: 24-33-1 (+7.4u)
K.Hunt Anytime TD Scorer Yes+205
1.03u
Only INS10 carry, 5 of 6 short yardage carries in 3rd/4th&short
Ryan Sura
Ryan Sura
Last 30d: 95-93-0 (+3.3u)
T.Thornton o17.5 Longest Reception-120
1u
P.Mahomes o28.5 Rush Yds-115
1.15u
Chris Raybon
Chris Raybon
Last 30d: 24-33-1 (+7.4u)
KC -300
0.33u
KC off L w/ Mahomes 15-5 SU but 10-10 ATS
Firefighter Bets
Firefighter Bets
Last 30d: 132-125-1 (-2.0u)
C.Skattebo o35.5 Rush Yds-120
0.83u
T.Thornton o28.5 Rec Yds-115
0.87u
YBK Picks.com
Last 30d: 52-35-3 (+28.7u)
Over 44.5-105
2u
Cam Is Money
Cam Is Money
Last 30d: 59-81-3 (-20.8u)
T.Johnson o22.5 Rec Yds-117
1u
Babs .
Babs .
Last 30d: 79-76-0 (+5.0u)
P.Mahomes o22.5 Pass Comp+105
0.32u
Mjaybrod
Mjaybrod
Last 30d: 76-84-3 (+0.3u)
NYG +260
0.25u
Shock the world Russ
CeeJ Sports
CeeJ Sports
Last 30d: 8-6-0 (+0.8u)
W.Robinson o44.5 Rec Yds-120
1.2u
DeadPresPicks
DeadPresPicks
Last 30d: 13-25-0 (+2.0u)
KC -6-108
0.69u
Mjaybrod
Mjaybrod
Last 30d: 76-84-3 (+0.3u)
NYG +6-110
1u
Not so fast Mahomo
Allan Lem
Allan Lem
Last 30d: 121-101-6 (+6.0u)
T.Nubin u6.5 Tackles + Ast+105
0.5u
Tailing @The_Oddsmaker
Sean Koerner
Sean Koerner
Last 30d: 36-33-0 (+1.6u)
T.Nubin u6.5 Tackles + Ast+105
0.53u
Gave out on Action Playbook
Matthew Freedman
Matthew Freedman
Last 30d: 22-33-0 (-8.1u)
M.Nabers Anytime TD Scorer Yes+132
0.5u
Projection: +119. For more, check out the Fantasy Life player projections.
T.Tracy u26.5 Rush Yds-110
1.1u
Projection: 15.6. For more, check out the Fantasy Life player projections.
Roger Goodell
Roger Goodell
Last 30d: 45-31-2 (+6.7u)
W.Robinson o42.2 Rec Yds-120
0.5u
Gilles Gallant
Gilles Gallant
Last 30d: 21-75-0 (-13.0u)
W.Robinson Anytime TD Scorer Yes+350
0.5u
💰🦡 Jake
💰🦡 Jake
Last 30d: 99-131-2 (+27.0u)
C.Skattebo o35.5 Rush Yds-110
1u
Stuck 🚨
Stuck 🚨
Last 30d: 47-54-2 (-0.5u)
NYG +6.5-105
0.5u
Matt Moore
Matt Moore
Last 30d: 11-11-0 (-0.6u)
NYG +6.5-110
1.1u
Firefighter Bets
Firefighter Bets
Last 30d: 132-125-1 (-2.0u)
T.Kelce o43.5 Rec Yds-115
1u
Gilles Gallant
Gilles Gallant
Last 30d: 21-75-0 (-13.0u)
M.Nabers Anytime TD Scorer Yes+170
1u
Action Pod NFL Picks
Action Pod NFL Picks
Last 30d: 45-121-0 (-23.6u)
K.Hunt Anytime TD Scorer Yes+220
2.2u
@Stuckey2 Favorite ATD
Kenny Ducey
Kenny Ducey
Last 30d: 28-23-2 (+2.9u)
KC -6-110
1u
Greg Matherne
Greg Matherne
Last 30d: 29-34-1 (+7.9u)
KC -6-110
0.5u
Boomer Betz
Boomer Betz
Last 30d: 132-115-2 (+28.5u)
KC -5.5-113
0.88u
Brandon Kravitz
Brandon Kravitz
Last 30d: 49-65-0 (-9.2u)
NYG +6-110
1.1u
This likely closes south of 6 so I want in now. Russ is cooking and Nabers in uncoverable. If they can just get to 20, there’s no way the Chiefs cover this #. 👨‍🍳
Sandy Plashkes
Sandy Plashkes
Last 30d: 88-96-2 (+11.0u)
KC -5.5-110
1.5u
FTN Fantasy
FTN Fantasy
Last 30d: 61-52-1 (+7.0u)
NYG +6-110
1u
Action Pod NFL Picks
Action Pod NFL Picks
Last 30d: 45-121-0 (-23.6u)
KC -5.5-110
0.91u
Week 3 Lookahead @wheatonbrando https://myaction.app/wBCiOGTOBWb
Brandon Anderson
Brandon Anderson
Last 30d: 29-105-0 (-26.7u)
KC -5.5-115
1.3u
I don't need to tell you why the Chiefs are better than the Giants — though I might need you to let me know why this game was chosen for Sunday Night Football? — so instead let's focus on the number grab here at -5.5 (FanDuel). There are two outcomes for the Chiefs this weekend. Either Kansas City beats Philadelphia in the Super Bowl rematch and gains bettors' confidence back, pushing this line to -6 or -7, maybe even past both key numbers… or the Chiefs lose again, fall to 0-2, and face an unprecedented-for-them kitchen sink spot against the lowly Giants in a game no one thinks they have any shot of blowing and dropping to 0-3. Either way, this line rises! Heck, just the Giants losing badly to the Cowboys could do that, and they've lost by at least five points in 15 of the last 18 meetings. There's another reason this line could move in our favor — we might get rookie QB Jaxson Dart making his debut, especially with a Sunday night audience on tap and Brian Daboll not wanting to get himself embarrassed or fired early. Any rookie QB debuting in primetime against an aggressive, blitzing Steve Spagnuolo is likely to struggle. Really, this is all about the -5.5. If this line somehow moves toward the Giants, we lose very little — four and five aren't particularly important key numbers, and there's no chance this ever gets to -3 or the Chiefs would get hammered. But if the lines goes the other way, both six and seven are key numbers in today's NFL, and we could even end up at -7.5 on the other side of both. Play the Chiefs now and stay ahead of the line move.

Chiefs vs. Giants Previews & Analysis

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    Sep 21, 2025 UTC
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    3 Shockingly Large SNF Prop Edges

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    Sep 21, 2025 UTC
  • Wiseguys Hounding Chiefs-Giants Total article feature image

    Wiseguys Hounding Chiefs-Giants Total

    PJ Walsh
    Sep 21, 2025 UTC
  • Giants vs. Chiefs: +200 SGP for Sunday Night Football article feature image

    Giants vs. Chiefs: +200 SGP for Sunday Night Football

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    Sep 21, 2025 UTC
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Chiefs vs. Giants Props

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Line Movement Tracker

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Chiefs vs. Giants Public Betting Percentages

Away Logo

Chiefs

Public

57%

Bets%

43%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Giants
2-31-11-2N/A2-3
Chiefs
2-31-11-11-21-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Giants
1-40-21-2N/A1-4
Chiefs
3-21-11-12-11-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Giants
1-4N/AN/AN/A1-4
Chiefs
2-3N/AN/A1-21-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 14th@DALL 37-40+4.5 WO 44.5DAL +194
Sep 7th@WASL 6-21+6.5 LU 45.5WAS +230
Aug 22ndNEW 42-10-4.5 WO 36.5NYG -225
Aug 16thNYJW 31-12-3 WO 37.5NYG -162
Aug 9th@BUFW 34-25+2.5 WO 37.5NYG +130

Giants vs. Chiefs Injury Updates

Giants Injuries

  • Darius Slayton
    WR

    Slayton is out with hamstring

    Out

  • Malik Nabers
    WR

    Nabers is out with knee

    Out

Chiefs Injuries

  • Rashee Rice
    WR

    Rice is out with suspension

    Out

Team Stats
306
Total Yards
281
67
Total Plays
61
4.6
Yards Per Play
4.6
224
YDS
160
22/37
Comps/Atts
18/32
5.154
YPA
4.441
1/0
TDs/INTs
0/2
2/23
Sacks/Yards
2/9
105
Rush Yards
130
28
Attempts
27
3.75
YPC
4.815
1
TDs
1

Turnovers

0
Fumbles Lost
0
0
Interceptions
2

Efficiency

2/3 66.67%
Redzone
1/3 33.33%
8/15 0%
3rd Down
1/10 0%
0/0 0%
4th Down
1/4 0%

First Downs

22
Total
19
13
Pass
7
6
Rush
8
3
Penalty
4
8/85
Penalties/Yards
7/82
31:50
Possession
28:10

Chiefs vs. Giants Odds Comparison

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Chiefs at Giants Team Totals

MatchupOverUnder
Chiefs
2-3
o26-111
u26-111
Giants
1-4
o19.5-111
u19.5-111