49ers vs. Seahawks Odds & Betting Predictions - September 7, 2025
49ers at Seahawks
8:05 pm • FOX49ers at Seahawks Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 49ers 1-0 | -1.5 | -2.5-112 | o43.5-110 | -132 |
 Seahawks 0-1 | u45.5 | +2.5-108 | u43.5-110 | +112 |
Lumen FieldSeattle
49ers vs. Seahawks Expert Picks
Ryan Sura
Last 30d: 67-72-4 (-6.7u)
J.Jennings o40.5 Rec Yds (Live)-115
1.15u
JC Cornell
Last 30d: 72-87-0 (-41.9u)
Z.Charbonnet o51.5 Rush Yds (Live)-114
1.14u
Z.Charbonnet o1 Longest Rush (Live)-110
1u
J.Smith-Njigba o80.5 Rec Yds (Live)-115
2.61u
R.Pearsall o69.5 Rec Yds (Live)-117
2.56u
C.McCaffrey Anytime TD Scorer Yes (Live)+130
0.77u
Ryan Sura
Last 30d: 67-72-4 (-6.7u)
SF -130
1.15u
Sir Lockselot
Last 30d: 24-64-0 (-59.8u)
C.McCaffrey Anytime TD Scorer Yes-135
3u
📚Player Profit
🔑 C.McCaffrey ATTD -135 (Player Profit) 3u
If you saw money on the ground, would you pick it up? This is the best odds you are gonna get all year on CMC. Take the free money and run.
Code: sirlocks for 10% off every deposit at playerprofit.com
Cam Is Money
Last 30d: 45-61-0 (-13.5u)
C.McCaffrey Anytime TD Scorer Yes-125
1u
Vegas Refund
Last 30d: 18-18-0 (-2.0u)
SEA +2-110
1.1u
Mjaybrod
Last 30d: 20-39-0 (-21.6u)
Under 43.5-110
0.91u
Nasty one
Matthew Freedman
Last 30d: 11-6-0 (+2.0u)
Over 43.5-104
1.04u
Projection: 45.6. For more, check out the Fantasy Life game model.
MJC Locks
Last 30d: 3-3-0 (+1.6u)
B.Purdy 2+ TDs Yes+10000
0.05u
B.Purdy o3.5 Rush Att-115
1u
B.Purdy Anytime TD Scorer Yes+650
0.15u
Nick Giffen
Last 30d: 22-82-0 (+9.1u)
Over 43-110
0.55u
Action Playbook LIVE
Markus Markets
Last 30d: 19-14-2 (+8.2u)
K.Walker o24.5 Rec Yds+235
0.25u
K.Walker o29.5 Rec Yds+330
0.1u
Shady Biev
Last 30d: 24-30-0 (-9.2u)
SEA +109
1.5u
Markus Markets
Last 30d: 19-14-2 (+8.2u)
K.Walker o19.5 Rec Yds+162
0.25u
K.Walker o13.5 Rec Yds-118
1u
Gilles Gallant
Last 30d: 9-16-0 (+4.6u)
G.Kittle Anytime TD Scorer Yes+190
1.9u
Austin Pendergrass
Last 30d: 65-46-0 (+2.1u)
R.Pearsall o3.5 Recs-125
0.4u
Sean Zerillo
Last 30d: 190-201-4 (-1.1u)
SEA +111
0.25u
Exchange
Top Shelf Action 🥃
Last 30d: 126-151-2 (-33.1u)
Under 43.5-110
0.91u
S.Darnold o1.5 Pass TDs+160
0.5u
CeeJ Sports
Last 30d: 16-4-1 (+9.6u)
C.Kupp o3.5 Recs-122
1u
Took this on Novig at the best price in the market! Use code CEEJ to sign up with Novig and get bonus funds on your 1st deposit!
Nick Giffen
Last 30d: 22-82-0 (+9.1u)
Z.Charbonnet Last TD Scorer Yes+1700
0.1u
Z.Charbonnet Anytime TD Scorer Yes+390
1.95u
Grant Neiffer
Last 30d: 45-126-10 (+31.8u)
G.Kittle Anytime TD Scorer Yes+175
0.88u
Kenny Ducey
Last 30d: 13-10-1 (+2.6u)
SEA +1.5-110
1.1u
Brandon Anderson
Last 30d: 7-20-0 (-2.4u)
K.Walker o59.5 Rush Yds-115
0.75u
There's also one key matchup that's very worrying for San Francisco: Seattle's run game.
Klint Kubiak is the new play caller in Seattle, and if preseason is any indication, his presence could transform this Seahawks rushing attack. A young offensive line that was widely panned as consensus bottom-three in the league suddenly looked outstanding, and Seattle was ripping off big runs left and right.
San Francisco's pass defense was good last season, but the 49ers ranked bottom 10 by DVOA against the run and entire the season with a gaping hole at defensive tackle. The 49ers allowed the 5th most fantasy points to opposing RBs last season, letting 10 RBs rush for 70+ yards and giving up a league-high 18 rushing TDs to opposing RBs.
Kenneth Walker looks healthy and should get plenty of touches in Kubiak's system. He had a touchdown in both 49ers games last fall.
Let's back Walker to go over 59.5 yards, and as a slight escalator, we'll place a portion of our bet on Walker going over his rushing line and also finding the endzone at +323 (FanDuel).
Action Pod NFL Picks
Last 30d: 9-19-0 (-5.8u)
K.Walker o59.5 Rush Yds-115
1u
@wheatonbrando https://myaction.app/TqfB5ck7pWb
Jeremiah Rose
Last 30d: 24-26-3 (+0.4u)
C.McCaffrey Anytime TD Scorer Yes-120
0.1u
Promo Boost
Chris Gimino
Last 30d: 13-9-0 (+7.6u)
B.Purdy u32.5 Pass Att-115
1u
💰🦡 Jake
Last 30d: 90-92-8 (+4.4u)
SF -0.5 (1H)-110
1.1u
Ryan Sura
Last 30d: 67-72-4 (-6.7u)
G.Kittle o59.5 Rec Yds-110
1.1u
Royals Props
Last 30d: 7-14-0 (-9.0u)
G.Kittle o60.5 Rec Yds-125
1.25u
Fanatics
Brandon Kravitz
Last 30d: 16-27-0 (-8.3u)
SEA +1.5-105
1.05u
Top Shelf Action 🥃
Last 30d: 126-151-2 (-33.1u)
SEA +1.5-105
1.05u
Early season divisional underdogs
Overall: 130-66-6,66% (ROI:27%)
49ers vs. Seahawks Previews & Analysis
49ers vs. Seahawks Props
Prop Projections
There are no prop projections found for the selected slate. Please check back later.
Prop Odds Comparison
Line Movement Tracker
49ers vs. Seahawks Public Betting Percentages
Betting Trends
- Seahawks are 0-1 in their last 5 games.
- Seahawks are 0-1 in their last 5 games against the spread
- The totals have gone OVER in 0 of Seahawks' last 1 games
- The totals have gone OVER in 0 of Seahawks' 1 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
49ers vs. Seahawks Injury Updates
49ers Injuries
- Demarcus RobinsonWR
Robinson is out with suspension
Out
- George KittleTE
Kittle is out with hamstring
Out
- Eddy PineiroK
Pineiro is questionable with knee
Questionable
- Brandon AiyukWR
Aiyuk is out with knee
Out
- Jauan JenningsWR
Jennings is questionable with shoulder
Questionable
- Brock PurdyQB
Purdy is out with toe
Out
- Jacob CowingWR
Cowing is out with hamstring
Out
- Jordan WatkinsWR
Watkins is doubtful with ankle
Doubtful
- Jordan JamesRB
James is doubtful with finger
Doubtful
Seahawks Injuries
- Uchenna NwosuLB
Nwosu is out with knee
Out
Team Stats
49ers vs. Seahawks Odds Comparison
Could not load odds
49ers at Seahawks Team Totals
MatchupOverUnder | ||
|---|---|---|
49ers 1-0 | o22.5-121 | u22.5-102 |
Seahawks 0-1 | o20.5-112 | u20.5-110 |