49ers vs. Seahawks Odds & Betting Predictions - September 7, 2025
49ers at Seahawks
8:05 pm • FOX49ers at Seahawks Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 49ers 6-11 | -1.5 | -1.5-110 | o45.5-110 | -124 |
 Seahawks 10-7 | u45.5 | +1.5-110 | u45.5-110 | +105 |
49ers vs. Seahawks Previews & Analysis
49ers vs. Seahawks Props
Prop Projections
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Prop Odds Comparison
Line Movement Tracker
49ers vs. Seahawks Public Betting Percentages
Betting Trends
- Seahawks are 3-2 in their last 5 games.
- Seahawks are 1-3 in their last 5 games against the spread
- Seahawks are 4-3 in their road games against the spread
- The totals have gone OVER in 3 of Seahawks' last 5 games
- The totals have gone OVER in 4 of Seahawks' 9 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Seahawks vs. 49ers Injury Updates
Seahawks Injuries
- Kenneth WalkerRB
Walker is out with ankle
Out
- Abraham LucasT
Lucas is out with abdomen
Out
- Josh JobeCB
Jobe is out with knee
Out
- Mike MorrisDE
Morris is questionable with ankle
Questionable
- Jerrick ReedFS
Reed is out with quad
Out
- Brandon PiliNT
Pili is out with illness
Out
- Byron MurphyDE
Murphy is questionable with back
Questionable
49ers Injuries
- Trent WilliamsT
Williams is out with ankle
Out
- Christian McCaffreyRB
McCaffrey is out with knee
Out
- George KittleTE
Kittle is questionable with ankle
Questionable
- George OdumS
Odum is out with knee
Out
- Kevin GivensDE
Givens is questionable with groin
Questionable
- Andre DillardOL
Dillard is questionable with concussion
Questionable
- Mitch WishnowskyP
Wishnowsky is out with back
Out
- Brandon AiyukWR
Aiyuk is out with leg
Out
- Colton McKivitzOL
McKivitz is questionable with knee
Questionable
- Ben BartchOL
Bartch is out with ankle
Out
- Deommodore LenoirDB
Lenoir is out with shoulder
Out
- Spencer BurfordOL
Burford is out with calf
Out
- Brock PurdyQB
Purdy is out with elbow
Out
- Ji'Ayir BrownS
Brown is questionable with ankle
Questionable
- Robert BealDE
Beal is out with ankle
Out
- Darrell LuterCB
Luter is doubtful with pelvis
Doubtful
- Renardo GreenDB
Green is questionable with neck
Questionable
- passing yards
-4320pyds - passing touchdowns-21ptd
- rushing yards
Kenneth Walker573ryds - rushing touchdowns
Zach Charbonnet8rtd
| Starter | 2ND | 3RD | 4TH | |
|---|---|---|---|---|
| QB | Geno Smith | Sam Howell | ||
| RB | Kenneth Walker | Zach Charbonnet | Kenny McIntosh | George Holani |
| WR | Jaxon Smith-Njigba | |||
| TE | Noah Fant | Pharaoh Brown | AJ Barner | Brady Russell |
| LT | Charles Cross | Stone Forsythe | ||
| LG | Laken Tomlinson | |||
| C | Olu Oluwatimi | Jalen Sundell | ||
| RG | Anthony Bradford | Christian Haynes | Sataoa Laumea | |
| RT | Abraham Lucas | George Fant | Michael Jerrell | |
| WLB | Tyrice Knight | |||
| MLB | Drake Thomas | Patrick O'Connell | ||
| SLB | Uchenna Nwosu | Derick Hall | Jamie Sheriff | |
| LCB | Tre Brown | |||
| SS | Rayshawn Jenkins | K'Von Wallace | ||
| FS | Julian Love | Coby Bryant | Ty Okada | |
| RCB | Riq Woolen | Nehemiah Pritchett | ||
| P | Michael Dickson | |||
| H | Michael Dickson | |||
| LS | Chris Stoll | |||
| DE | Jarran Reed | Byron Murphy | ||
| RUSH | Dre'Mont Jones | Boye Mafe | ||
| K | Jason Myers | |||
| LWR | DK Metcalf | Jake Bobo | Cody White | |
| RWR | Tyler Lockett | Dareke Young | ||
| NT | Johnathan Hankins | Cameron Young | ||
| NB | Devon Witherspoon | Artie Burns | ||
| DT | Leonard Williams | Mike Morris |
49ers vs. Seahawks Odds Comparison
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49ers at Seahawks Team Totals
MatchupOverUnder | ||
|---|---|---|
49ers 6-11 | N/A | N/A |
Seahawks 10-7 | N/A | N/A |