Illinois vs. Duke Odds & Betting Predictions - September 6, 2025
Illinois at Duke
4:00 pm • ESPNIllinois at Duke Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Illinois 5-3 | -2.5 | -2.5-108 | o49-110 | -134 |
Duke 4-3 | u49.5 | +2.5-112 | u49-110 | +114 |

Brooks Field at Wallace Wade StadiumDurham
Illinois vs. Duke Expert Picks
Sir Lockselot
Last 30d: 30-60-0 (-19.5u)
DUKE +114
3u
📚Player Profit
🔑 Duke ML +114 (Player Profit) 3u
Mensah > Altmyer. Amazing value at home for what I think is the more talented team. Illinois struggles on the road generally. Go blue devils!
Code: sirlocks for 10% off every deposit at playerprofit.com
Vegas Refund
Last 30d: 40-35-1 (+1.4u)
DUKE +2.5-105
1.05u
Sandy Plashkes
Last 30d: 95-104-2 (-3.7u)
DUKE +2.5-110
1.1u

Sean Zerillo
Last 30d: 102-128-5 (+1.8u)
Over 48.5-110
0.25u
Mjaybrod
Last 30d: 85-113-1 (-21.2u)
DUKE +3-110
1u
Outright for the blue devils
Big Bets On Campus (CFB)
Last 30d: 48-57-3 (-11.3u)
DUKE o23.5 Team Total-110
1u
@_Collin1 https://myaction.app/jBs4sSa5pWb
DUKE +3-105
1u
@Stuckey2 @_Collin1 https://myaction.app/jBs4sSa5pWb
Brian Bitler
Last 30d: 75-67-2 (+12.0u)
DUKE +2.5+105
3u
Stuck 🚨
Last 30d: 58-67-1 (-1.5u)
DUKE +3-105
0.4u
Collin Wilson
Last 30d: 100-79-1 (+12.6u)
DUKE +3-108
1.08u
Backing Darian Mensah v Illinois 3-3-5. Altmyer still breaking in new targets. Both teams flawless box scores in Week 1
Brian Bitler
Last 30d: 75-67-2 (+12.0u)
DUKE +3-108
3u
DeadPresPicks
Last 30d: 8-20-0 (-0.4u)
DUKE +3-110
0.75u
Ryan Sura
Last 30d: 92-104-1 (-11.6u)
DUKE +3-106
1.06u
Illinois vs. Duke Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Illinois vs. Duke Public Betting Percentages
Betting Trends
- Duke are 2-3 in their last 5 games.
- Duke are 1-4 in their last 5 games against the spread
- Duke are 2-1 in their road games against the spread
- The totals have gone OVER in 3 of Duke' last 5 games
- The totals have gone OVER in 3 of Duke' 4 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Team Stats
296
YDS
356
22/31
Comps/Atts
25/39
9.548387096774194
YPA
9.128205128205128
3/0
TDs/INTs
2/1
4/29
Sacks/Yards
2/7
Illinois vs. Duke Odds Comparison
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Illinois at Duke Team Totals
MatchupOverUnder | ||
|---|---|---|
Illinois 5-3 | o25-111 | u25-114 |
Duke 4-3 | o23.5-125 | u23.5-106 |






