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Illinois vs. Duke Odds & Betting Predictions - September 6, 2025

Illinois at Duke

4:00 pm • ESPN

Illinois Fighting Illini

4-1
45
45 - 19

Duke Blue Devils

3-2
19

Illinois at Duke Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Illinois
4-1
-2.5
-2.5-108
o49-110
-134
Duke
3-2
u49.5
+2.5-112
u49-110
+114
location pinSaturday 4:00 p.m.
September 06, 2025
Brooks Field at Wallace Wade StadiumDurham
Illinois vs. Duke Expert Picks
Sir Lockselot
Sir Lockselot
Last 30d: 30-58-0 (-21.7u)
DUKE +114
3u
📚Player Profit 🔑 Duke ML +114 (Player Profit) 3u Mensah > Altmyer. Amazing value at home for what I think is the more talented team. Illinois struggles on the road generally. Go blue devils! Code: sirlocks for 10% off every deposit at playerprofit.com
Vegas Refund
Vegas Refund
Last 30d: 36-36-2 (-3.7u)
DUKE +2.5-105
1.05u
Sandy Plashkes
Sandy Plashkes
Last 30d: 74-104-3 (-10.5u)
DUKE +2.5-110
1.1u
Sean Zerillo
Sean Zerillo
Last 30d: 148-170-6 (-11.0u)
Over 48.5-110
0.25u
Mjaybrod
Mjaybrod
Last 30d: 68-84-3 (-10.1u)
DUKE +3-110
1u
Outright for the blue devils
Firefighter Bets
Firefighter Bets
Last 30d: 130-122-1 (-1.2u)
DUKE +2.5-110
1u
Big Bets On Campus (CFB)
Big Bets On Campus (CFB)
Last 30d: 64-63-2 (+2.2u)
DUKE o23.5 Team Total-110
1u
@_Collin1 https://myaction.app/jBs4sSa5pWb
DUKE +3-105
1u
@Stuckey2 @_Collin1 https://myaction.app/jBs4sSa5pWb
Brian Bitler
Brian Bitler
Last 30d: 74-72-1 (-6.5u)
DUKE +2.5+105
3u
Stuck 🚨
Stuck 🚨
Last 30d: 45-55-2 (-0.8u)
DUKE +3-105
0.4u
Collin Wilson
Collin Wilson
Last 30d: 86-59-3 (+13.9u)
DUKE +3-108
1.08u
Backing Darian Mensah v Illinois 3-3-5. Altmyer still breaking in new targets. Both teams flawless box scores in Week 1
Brian Bitler
Brian Bitler
Last 30d: 74-72-1 (-6.5u)
DUKE +3-108
3u
DeadPresPicks
DeadPresPicks
Last 30d: 15-23-0 (+2.1u)
DUKE +3-110
0.75u
Ryan Sura
Ryan Sura
Last 30d: 99-94-2 (+7.7u)
DUKE +3-106
1.06u

Illinois vs. Duke Previews & Analysis

  • Illinois vs. Duke: Early And Often article feature image

    Illinois vs. Duke: Early And Often

    Doug Ziefel•
    Sep 6, 2025 UTC
  • Expert College Football Picks For Week 2! | College Football Best Bets & Props On BBOC article feature image

    Expert College Football Picks For Week 2! | College Football Best Bets & Props On BBOC

    Mike Calabrese•
    Sep 6, 2025 UTC
  • Collin Wilson's Week 2 ML Round Robin article feature image

    Collin Wilson's Week 2 ML Round Robin

    Collin Wilson•
    Sep 5, 2025 UTC
  • Stuckey & Wilson: Our Top ML Dogs for Week 2 article feature image

    Stuckey & Wilson: Our Top ML Dogs for Week 2

    Collin Wilson•
    Sep 5, 2025 UTC
See more NCAAF Coverage Right Arrow

Prop Odds Comparison

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Line Movement Tracker

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Illinois vs. Duke Public Betting Percentages

Away Logo

Illinois

Public

Home Logo

Duke

37%

Bets%

63%

Money%

NCAAF Public Betting Right Arrow

Betting Trends

  • Duke are 3-2 in their last 5 games.
  • Duke are 2-3 in their last 5 games against the spread
  • Duke are 1-1 in their road games against the spread
  • The totals have gone OVER in 4 of Duke' last 5 games
  • The totals have gone OVER in 3 of Duke' 3 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Duke		2-31-21-12-10-2
Illinois		4-13-01-12-01-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Duke		4-13-01-12-12-0
Illinois		3-21-22-01-12-0

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Duke		3-2N/AN/A3-00-2
Illinois		4-1N/AN/A2-01-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Aug 28thELOW 45-17-36.5 LO 51-
Jan 3rd@MISSL 20-52+18.5 LO 51.5MISS +650
Nov 30th@WFW 23-17-3.5 WU 53.5DUKE -165
Nov 24thVTW 31-28+2.5 WO 45.5DUKE +114
Nov 9th@NCSTW 29-19+3.5 WU 51.5DUKE +128
Team Stats

Total

419
Total Yards
438
73
Total Plays
63
5.739726027397261
Yards Per Play
6.9523809523809526

Passing

296
YDS
356
22/31
Comps/Atts
25/39
9.548387096774194
YPA
9.128205128205128
3/0
TDs/INTs
2/1
4/29
Sacks/Yards
2/7

Rushing

123
Rush Yards
82
42
Attempts
24
2.9285714285714284
YPC
3.4166666666666665
3
TDs
0

Turnovers

0
Fumbles Lost
4
0
Interceptions
1

Efficiency

5/5 100%
Redzone
3/4 75%
5/13 0%
3rd Down
4/10 0%
2/2 0%
4th Down
1/2 0%

First Downs

25
Total
21
13
Pass
14
8
Rush
5
4
Penalty
2

Misc

7/51
Penalties/Yards
6/69

Illinois vs. Duke Odds Comparison

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Illinois at Duke Team Totals

MatchupOverUnder
Illinois
4-1
o25-111
u25-114
Duke
3-2
o23.5-125
u23.5-106