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Illinois vs. Duke Odds & Betting Predictions - September 6, 2025

Illinois at Duke

4:00 pm • ESPN

Illinois Fighting Illini

9-4
45
45 - 19

Duke Blue Devils

9-5
19

Illinois at Duke Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Illinois
9-4
-2.5
-2.5-108
o49-110
-134
Duke
9-5
u49.5
+2.5-112
u49-110
+114
location pinSaturday 4:00 p.m.
September 06, 2025
Brooks Field at Wallace Wade StadiumDurham
Illinois vs. Duke Expert Picks
Sir Lockselot
Sir Lockselot
Last 30d: 25-58-1 (-12.9u)
DUKE +114
3u
📚Player Profit 🔑 Duke ML +114 (Player Profit) 3u Mensah > Altmyer. Amazing value at home for what I think is the more talented team. Illinois struggles on the road generally. Go blue devils! Code: sirlocks for 10% off every deposit at playerprofit.com
Vegas Refund
Vegas Refund
Last 30d: 29-25-0 (+1.8u)
DUKE +2.5-105
1.05u
Sandy Plashkes
Sandy Plashkes
Last 30d: 86-84-5 (-7.8u)
DUKE +2.5-110
1.1u
Mike McNamara
Mike McNamara
Last 30d: 58-91-1 (-6.1u)
ILL -135
0.3u
Sean Zerillo
Sean Zerillo
Last 30d: 50-64-0 (-1.8u)
Over 48.5-110
0.25u
Mjaybrod
Mjaybrod
Last 30d: 54-52-0 (+10.6u)
DUKE +3-110
1u
Outright for the blue devils
Ryan Minion
Ryan Minion
Last 30d: 226-259-4 (+28.6u)
ILL -130
$1.00
Big Bets On Campus (CFB)
Big Bets On Campus (CFB)
Last 30d: 5-3-1 (+1.8u)
DUKE +3-105
1u
@Stuckey2 @_Collin1 https://myaction.app/jBs4sSa5pWb
DUKE o23.5 Team Total-110
1u
@_Collin1 https://myaction.app/jBs4sSa5pWb
Brian Bitler
Brian Bitler
Last 30d: 89-91-1 (-23.6u)
DUKE +2.5+105
3u
Stuck 🚨
Stuck 🚨
Last 30d: 53-63-1 (-3.9u)
DUKE +3-105
0.4u
Collin Wilson
Collin Wilson
Last 30d: 4-7-1 (-2.1u)
DUKE +3-108
1.08u
Backing Darian Mensah v Illinois 3-3-5. Altmyer still breaking in new targets. Both teams flawless box scores in Week 1
Brian Bitler
Brian Bitler
Last 30d: 89-91-1 (-23.6u)
DUKE +3-108
3u
DeadPresPicks
DeadPresPicks
Last 30d: 4-7-1 (-3.5u)
DUKE +3-110
0.75u
Doug Ziefel
Doug Ziefel
Last 30d: 133-143-1 (+8.0u)
ILL -3-110
0.5u

Illinois vs. Duke Previews & Analysis

  • Illinois vs. Duke: Early And Often article feature image

    Illinois vs. Duke: Early And Often

    Doug Ziefel•
    Sep 6, 2025 UTC
  • Expert College Football Picks For Week 2! | College Football Best Bets & Props On BBOC article feature image

    Expert College Football Picks For Week 2! | College Football Best Bets & Props On BBOC

    Mike Calabrese•
    Sep 6, 2025 UTC
  • Collin Wilson's Week 2 ML Round Robin article feature image

    Collin Wilson's Week 2 ML Round Robin

    Collin Wilson•
    Sep 5, 2025 UTC
  • Stuckey & Wilson: Our Top ML Dogs for Week 2 article feature image

    Stuckey & Wilson: Our Top ML Dogs for Week 2

    Collin Wilson•
    Sep 5, 2025 UTC
See more NCAAF Coverage Right Arrow

Prop Odds Comparison

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Line Movement Tracker

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Illinois vs. Duke Public Betting Percentages

Away Logo

Illinois

Public

Home Logo

Duke

37%

Bets%

63%

Money%

NCAAF Public Betting Right Arrow

Betting Trends

  • Duke are 4-1 in their last 5 games.
  • Duke are 3-2 in their last 5 games against the spread
  • Duke are 4-2 in their road games against the spread
  • The totals have gone OVER in 4 of Duke' last 5 games
  • The totals have gone OVER in 4 of Duke' 6 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Duke		7-62-44-25-42-2
Illinois		7-4-15-1-12-35-1-11-3

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Duke		9-44-25-16-33-1
Illinois		5-71-64-12-53-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Duke		8-5N/AN/A6-32-2
Illinois		8-4N/AN/A6-11-3

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Aug 28thELOW 45-17-36.5 LO 51-
Jan 3rd@MISSL 20-52+18.5 LO 51.5MISS +650
Nov 30th@WFW 23-17-3.5 WU 53.5DUKE -165
Nov 24thVTW 31-28+2.5 WO 45.5DUKE +114
Nov 9th@NCSTW 29-19+3.5 WU 51.5DUKE +128
Team Stats

Total

419
Total Yards
438
73
Total Plays
63
5.739726027397261
Yards Per Play
6.9523809523809526

Passing

296
YDS
356
22/31
Comps/Atts
25/39
9.548387096774194
YPA
9.128205128205128
3/0
TDs/INTs
2/1
4/29
Sacks/Yards
2/7

Rushing

123
Rush Yards
82
42
Attempts
24
2.9285714285714284
YPC
3.4166666666666665
3
TDs
0

Turnovers

0
Fumbles Lost
4
0
Interceptions
1

Efficiency

5/5 100%
Redzone
3/4 75%
5/13 0%
3rd Down
4/10 0%
2/2 0%
4th Down
1/2 0%

First Downs

25
Total
21
13
Pass
14
8
Rush
5
4
Penalty
2

Misc

7/51
Penalties/Yards
6/69

Illinois vs. Duke Odds Comparison

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Illinois at Duke Team Totals

MatchupOverUnder
Illinois
9-4
N/A
N/A
Duke
9-5
N/A
N/A