Clemson vs. Louisville Odds & Betting Predictions - November 15, 2025
Clemson at Louisville
12:30 am • ESPNClemson at Louisville Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 Clemson 4-5 | -6.5 | +3-110 | o50.5-112 | +130 |
 Louisville 7-2 | u60.5 | -3-110 | u50.5-108 | -155 |
L&N Federal Credit Union StadiumLouisville
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Clemson vs. Louisville Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Clemson vs. Louisville Public Betting Percentages
Betting Trends
- Louisville are 4-1 in their last 5 games.
- Louisville are 1-4 in their last 5 games against the spread
- Louisville are 3-0 in their road games against the spread
- The totals have gone OVER in 3 of Louisville' last 5 games
- The totals have gone OVER in 4 of Louisville' 6 last games at home
Matchup History
Against the Spread (ATS) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 3-6 | 0-6 | 3-0 | 2-6 | 1-0 |
| 3-6 | 1-5 | 2-1 | 3-6 | N/A |
Over/Under History
| overall | home o/u | away o/u | favorite o/u | underdog o/u | |
|---|---|---|---|---|---|
| 5-4 | 4-2 | 1-2 | 5-3 | 0-1 |
| 4-5 | 3-3 | 1-2 | 4-5 | N/A |
Straight-Up (ML) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 7-2 | N/A | N/A | 6-2 | 1-0 |
| 4-5 | N/A | N/A | 4-5 | N/A |
Last 5 Matchups
Team Stats
2596
YDS
2219
218/326
Comps/Atts
206/324
7.96
YPA
6.85
18/6
TDs/INTs
12/8
14/86
Sacks/Yards
18/138
24/28 85.7%
Redzone
25/28 89.3%
43/118 0%
3rd Down
49/123 0%
16/26 0%
4th Down
4/8 0%
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Penalties/Yards
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Clemson vs. Louisville Odds Comparison
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Clemson at Louisville Team Totals
MatchupOverUnder | ||
|---|---|---|
Clemson 4-5 | N/A | N/A |
Louisville 7-2 | N/A | N/A |