Phillies vs. Cubs Odds & Betting Predictions - April 21, 2026

Phillies at Cubs

11:40 pm • MARQ

Philadelphia Phillies

Chicago Cubs

pitcher		team	era	w-l
S.Imanaga			2.46	1-1
J.Luzardo			7.94	1-3

MatchupOpenSpreadTotalMoneyline
Phillies 8-14	+1.5	-1.5+165	o8.5-105	+100
Cubs 13-9	u8.5	+1.5-191	u8.5-115	-120

Tuesday 11:40 p.m.

April 21, 2026

Wrigley FieldChicago

67°Fahrenheit

0%Rain

7Wind

PHI +102

Under 8.5-115

0.31u

#EV Pinny -126 Circa -130 BO -125

PHI +105

Ultimate contrarian spot especially with how these teams did against each starter last week but think it’s the time to buy. Shotas stuff is up and has been great but overall i trust Luzardo more as he’s the unluckiest pitcher in baseball at the moment. Decent HR weather should hurt Shota more here, 1.93 HR/9 Last Season vs Luzardos .78 HR/9. Cubs lineup way better vs lefties this year but think those numbers will balance out eventually. Better starter imo and huge bullpen edge(no Duran but Cubs bullpen is actually in shambles rn) at + money. If they get to Shota at all it’s wraps. Gotta buy low on the corpse

Under 8.5-115

0.58u

Bet to 8 (-105)

Under 8.5-115

0.58u

(FD) See notes on FD - Also, hitter friendly weather, but negative run environment + pitcher leaning umpire.

CHC -118

0.47u

(FD) See notes on F5 (Would play either to -150)

CHC -122 (F5)

0.73u

(FD) Luzardo (2.45 SIERA/3.49 xERA) has pitched better than his 7.94 ERA (.417 BABIP, 41.2 LOB%, 23.1 HR/FB), but Imanaga (up 1.3 mph) has returned to All Star form (2.28/2.55). CHC proj LU 10 pt wRC+ edge v LHP since LY (CHC 125 wRC+ v LHP, PHI 59 as a team this year). CHC one of best defenses in the league (proj. LU +10 FRV already). (Splitting 1u 60/40 because PHI does have the better pen thus far and Palencia on IL).

Trigger's Triple-A Picks For Tuesday
Adam Trigger•
Apr 21, 2026 UTC
Trollo’s 3 Plays for Phillies vs. Cubs
Matt Trollo•
Apr 21, 2026 UTC

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No props found

MLB Public Betting

Cubs are 5-0 in their last 5 games.
Cubs are 4-1 in their last 5 games against the spread
Cubs are 4-5 in their road games against the spread
The totals have gone OVER in 2 of Cubs' last 5 games
The totals have gone OVER in 6 of Cubs' 13 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cubs	10-12	6-7	4-5	6-9	4-3
Phillies	4-18	2-13	2-5	4-15	0-3

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cubs	12-10	6-7	6-3	7-8	5-2
Phillies	10-11-1	8-6-1	2-5	10-8-1	0-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cubs	13-9	8-5	5-4	9-6	4-3
Phillies	8-14	5-10	3-4	8-11	0-3

date	opponent	score	spread	over/under	moneyline
Apr 20th	PHI	W 5-1	+1.5 W	U 7.5	CHC -114
Apr 19th	NYM	W 2-1	-1.5 L	U 8	CHC -139
Apr 18th	NYM	W 4-2	+1.5 W	U 8.5	CHC -118
Apr 17th	NYM	W 12-4	-1.5 W	O 10	CHC -152
Apr 15th	@PHI	W 11-2	+1.5 W	O 9	CHC +119

Tyler Austin
1B
Austin is out with knee
Out
Justin Steele
SP
Steele is out with elbow
Out
Jordan Wicks
SP
Wicks is out with arm
Out

Zack Wheeler
SP
Wheeler is out with shoulder
Out
Max Lazar
RP
Lazar is out with oblique
Out

Andrew Painter
SP
Andrew Painter was seen walking out to bullpen, he won't start but could be available in relief.
Questionable
Steward Berroa
RF
Berroa is out with shoulder
Out

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PITCHER		W-L	ERA	WHIP	K/9
LJ.Luzardo, P		1-3	7.94	1.456	11.91

HITTERS	AVG	OBP	SLG	HR
1T.Turner, SS	.244	.299	.356	2
2K.Schwarber, DH	.213	.357	.525	7
3B.Harper, 1B	.275	.370	.513	4
4A.Garcia, RF	.208	.303	.338	2
5J.Realmuto, C	.280	.368	.380	1
6A.Bohm, 3B	.133	.214	.187	1
7F.Reyes, LF	.333	.333	.333	1
8E.Sosa, 2B	.250	.300	.429	1
9B.Marsh, CF	.264	.289	.403	2

PITCHER		W-L	ERA	WHIP	K/9
LS.Imanaga, P		1-1	2.46	0.773	12.68

HITTERS	AVG	OBP	SLG	HR
1N.Hoerner, 2B	.322	.396	.506	3
2A.Bregman, 3B	.244	.317	.344	2
3S.Suzuki, DH	.229	.372	.257	0
4I.Happ, LF	.244	.359	.526	6
5C.Kelly, C	.315	.422	.481	2
6M.Busch, 1B	.169	.261	.195	0
7D.Swanson, SS	.192	.322	.411	5
8P.Crow-Armstrong, CF	.214	.275	.298	1
9M.Shaw, RF	.273	.305	.473	2