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Colts vs. Chargers Odds & Betting Predictions - October 19, 2025

Colts at Chargers

8:05 pm • CBS

Indianapolis Colts

7-1
38
38 - 24

Los Angeles Chargers

5-3
24

Colts at Chargers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Colts
7-1
+6
+2.5-106
o49-110
+120
Chargers
5-3
u45.5
-2.5-113
u49.5-112
-142
location pinSunday 8:05 p.m.
October 19, 2025
SoFi StadiumInglewood
Colts vs. Chargers Expert Picks
Mjaybrod
Mjaybrod
Last 30d: 81-101-0 (-12.0u)
Under 58.5 (Live)-110
0.5u
VegasIsMyBitch
VegasIsMyBitch
Last 30d: 12-9-1 (+0.9u)
IND +130
0.65u
Matt Moore
Matt Moore
Last 30d: 40-46-0 (-2.5u)
LAC -2.5-111
0.55u
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 194-187-1 (-14.8u)
T.Warren 60+ Receiving Yards Yes+108
0.97u
K.Vidal o13.5 Rec Yds-110
0.91u
Prop Bomb 🏝
Prop Bomb 🏝
Last 30d: 1-4-0 (-3.9u)
D.Jones o15.5 Rush Yds-112
1.12u
One glaring trend: the Chargers are leaking QB rushing yards because of how they play defense. They live in light coverage shells and rush four, trying to win with pressure without sending extra bodies. That consistently squeezes the pocket without actually closing lanes, so when the QB bails he’s running into space instead of traffic. The Chargers have already allowed 23 QB scrambles for 187 yards and 9 first downs, that league-high scramble volume (13.8%) is a direct product of their 2-3-6 and 3-3-5 shells generating pressure without lane integrity. We’ve already seen the exact archetype punish this three straight weeks: Mahomes 57, Bo Nix 33, Geno 20. None of those were designed runs, they were “nothing there, pull it and go.” PropsMadness has that archetype undefeated vs this defense with a large over-margin. Jones fits the same archetype. He doesn’t need scheme to hand him yards — he runs when the door opens. With how the Chargers rush, two clean escapes can clear this number. The only way this loses is if he never leaves structure or converts those same lanes into sacks instead of yards. #PlayerProps
Vegas Refund
Vegas Refund
Last 30d: 35-34-1 (-2.5u)
LAC -128
1.28u
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 194-187-1 (-14.8u)
C.Dicker o7.5 Kicking Pts-115
0.9u
Wags Wins
Wags Wins
Last 30d: 216-213-1 (-9.9u)
LAC -125
1.5u
Royals Props
Royals Props
Last 30d: 31-18-2 (+9.3u)
M.Pittman o49.5 Rec Yds-114
1u
YBK Picks.com
Last 30d: 64-38-3 (+47.2u)
LAC -2.5-105
2u
Chris Raybon
Chris Raybon
Last 30d: 18-31-1 (-11.7u)
T.Warren o57.5 Rec Yds-114
0.88u
Chris Gimino
Chris Gimino
Last 30d: 27-43-1 (-17.0u)
A.Pierce o2.5 Recs-102
0.98u
Matt DiLeo
Matt DiLeo
Last 30d: 41-37-0 (-2.1u)
Both Teams To Make 33+ Yard FG -120
0.83u
Picks Office
Picks Office
Last 30d: 120-98-4 (+15.3u)
IND +2.5-110
0.91u
X: PicksOffice
Cam Is Money
Cam Is Money
Last 30d: 74-79-1 (-1.4u)
A.Mitchell Anytime TD Scorer Yes+500
0.4u
J.Taylor o88.5 Rush Yds-110
0.91u
IND +2-105
0.95u
💰🦡 Jake
💰🦡 Jake
Last 30d: 104-120-8 (+0.2u)
Under 48.5-110
1.1u
Matt DiLeo
Matt DiLeo
Last 30d: 41-37-0 (-2.1u)
D.Jones o14.5 Rush Yds-114
1u
Will Brinson
Will Brinson
Last 30d: 10-13-1 (-2.5u)
LAC -1.5-111
1.11u
TAN Pod Touchdown Show
TAN Pod Touchdown Show
Last 30d: 20-73-2 (-7.7u)
O.Gadsden Anytime TD Scorer Yes+285
1.43u
@The_Oddsmaker https://myaction.app/MsfxZEmqyXb
J.Taylor 2+ TDs Yes+310
1.55u
@The_Oddsmaker https://myaction.app/MsfxZEmqyXb
David Payne
David Payne
Last 30d: 8-11-0 (-3.5u)
IND +100
1.5u
#SodaBet
Mjaybrod
Mjaybrod
Last 30d: 81-101-0 (-12.0u)
Under 48.5-110
1u
Obvious over soars under
Grant Neiffer
Grant Neiffer
Last 30d: 38-82-0 (+9.0u)
K.Allen Anytime TD Scorer Yes+210
1.05u
Q.Johnston Anytime TD Scorer Yes+190
0.95u
Gilles Gallant
Gilles Gallant
Last 30d: 27-86-1 (-14.4u)
J.Taylor 2+ TDs Yes+350
1.75u
Ryan Sura
Ryan Sura
Last 30d: 89-101-1 (-8.7u)
LAC -125
1.25u
Sandy Plashkes
Sandy Plashkes
Last 30d: 96-99-1 (+0.6u)
LAC -130
1.3u
The Favorites Podcast
The Favorites Podcast
Last 30d: 8-13-0 (-3.9u)
LAC -130
1.3u
@Stuckey2 https://myaction.app/4ocNrlaxxXb
Action Pod NFL Picks
Action Pod NFL Picks
Last 30d: 59-118-0 (-3.3u)
LAC -1.5-112
1u
@sundaysixpack @Stuckey2 https://myaction.app/AOwwgtQewXb
Sunday Six Pack
Sunday Six Pack
Last 30d: 11-13-0 (-3.4u)
LAC -1.5-111
1.11u
@Stuckey2 2 https://myaction.app/IHUc2sI9vXb
Boomer Betz
Boomer Betz
Last 30d: 170-173-2 (+4.6u)
M.Pittman o51.5 Rec Yds-110
0.91u
💰🦡 Jake
💰🦡 Jake
Last 30d: 104-120-8 (+0.2u)
K.Vidal Anytime TD Scorer Yes+100
0.1u
Stuck 🚨
Stuck 🚨
Last 30d: 53-60-0 (-1.4u)
LAC -125
0.6u
Boomer Betz
Boomer Betz
Last 30d: 170-173-2 (+4.6u)
LAC -108
1u
Bet105

Colts vs. Chargers Previews & Analysis

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Colts vs. Chargers Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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Colts vs. Chargers Public Betting Percentages

Away Logo

Colts

Public

Home Logo

Chargers

78%

Bets%

22%

Money%

NFL Public Betting Right Arrow

Betting Trends

  • Chargers are 3-2 in their last 5 games.
  • Chargers are 2-3 in their last 5 games against the spread
  • Chargers are 1-2 in their road games against the spread
  • The totals have gone OVER in 2 of Chargers' last 5 games
  • The totals have gone OVER in 2 of Chargers' 4 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Chargers		4-42-21-23-41-0
Colts		6-24-12-14-12-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Chargers		4-42-21-23-41-0
Colts		5-33-22-13-22-1

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Chargers		5-3N/AN/A4-31-0
Colts		7-1N/AN/A5-02-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Oct 12th@MIAW 29-27-3.5 LO 45.5LAC -185
Oct 5thWASL 10-27-3 LU 48.5WAS -164
Sep 28th@NYGL 18-21-6 LU 42.5NYG -280
Sep 21stDENW 23-20-2.5 WU 45.5LAC -155
Sep 16th@LVW 20-9-3.5 WU 46.5LAC -190

Chargers vs. Colts Injury Updates

Chargers Injuries

  • Najee Harris
    RB

    Harris is out with achilles

    Out

  • Hassan Haskins
    RB

    Haskins is out with hamstring

    Out

  • Omarion Hampton
    RB

    Hampton is out with ankle

    Out

Colts Injuries

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    Team Stats

    Total

    401
    Total Yards
    445
    58
    Total Plays
    74
    6.9
    Yards Per Play
    6

    Passing

    288
    YDS
    420
    23/34
    Comps/Atts
    37/55
    8.029
    YPA
    6.741
    2/0
    TDs/INTs
    3/2
    1/7
    Sacks/Yards
    3/29

    Rushing

    120
    Rush Yards
    54
    23
    Attempts
    16
    5.217
    YPC
    3.375
    3
    TDs
    0

    Turnovers

    0
    Fumbles Lost
    0
    0
    Interceptions
    2

    Efficiency

    4/5 80%
    Redzone
    3/4 75%
    5/11 0%
    3rd Down
    8/16 0%
    3/3 0%
    4th Down
    3/4 0%

    First Downs

    24
    Total
    25
    14
    Pass
    19
    9
    Rush
    4
    1
    Penalty
    2

    Misc

    3/42
    Penalties/Yards
    6/35
    25:33
    Possession
    34:27

    Colts vs. Chargers Odds Comparison

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    Colts at Chargers Team Totals

    MatchupOverUnder
    Colts
    7-1
    o23.5-115
    u23.5-108
    Chargers
    5-3
    o25-116
    u25-106