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LSU vs. Ole Miss Odds & Betting Predictions - September 27, 2025

LSU at Ole Miss

7:30 pm • ABC

LSU Tigers

6-4
19
19 - 24

Ole Miss Rebels

10-1
24

LSU at Ole Miss Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
LSU
6-4
-1.5
+2.5-104
o58.5-110
+122
Ole Miss
10-1
u56.5
-2.5-120
u58.5-110
-150
location pinSaturday 7:30 p.m.
September 27, 2025
Vaught-Hemingway StadiumOxford
LSU vs. Ole Miss Expert Picks
FTN Fantasy
FTN Fantasy
Last 30d: 110-130-1 (-31.6u)
MISS +3.5 (Live)-120
0.83u
MISS +150 (Live)
1.5u
Will Brinson
Will Brinson
Last 30d: 19-26-2 (-6.0u)
Over 57.5-120
1.2u
Wags Wins
Wags Wins
Last 30d: 193-192-1 (-9.4u)
MISS -122
1.23u
Capper Central
Capper Central
Last 30d: 92-74-0 (+7.3u)
MISS -125
1u
Brian Bitler
Brian Bitler
Last 30d: 96-86-1 (+19.2u)
MISS -1.5-112
2.68u
Brandon Kravitz
Brandon Kravitz
Last 30d: 76-86-2 (-4.9u)
MISS -1.5-108
0.5u
Vegas Refund
Vegas Refund
Last 30d: 34-35-0 (-4.7u)
MISS -125
1u
Royals Props
Royals Props
Last 30d: 34-36-4 (-7.0u)
LSU +1.5-108
1.08u
Mike Calabrese
Mike Calabrese
Last 30d: 32-45-0 (-14.9u)
LSU +105
1u
FTN Fantasy
FTN Fantasy
Last 30d: 110-130-1 (-31.6u)
MISS -1.5-110
0.91u
MISS -118
0.85u
MISS -0.5 (1H)-105
0.95u
MISS -1.5 (1Q)+128
1u
Big Bets On Campus (CFB)
Big Bets On Campus (CFB)
Last 30d: 41-38-0 (+3.5u)
D.Wright Anytime TD Scorer Yes+250
1u
@_Collin1 https://myaction.app/AoQQIE3ZYWb
Babs .
Babs .
Last 30d: 97-99-1 (-5.5u)
MISS -120
0.83u
Roger Goodell
Roger Goodell
Last 30d: 37-42-0 (-2.9u)
MISS -120
0.63u
Collin Wilson
Collin Wilson
Last 30d: 83-63-0 (+13.8u)
D.Wright Anytime TD Scorer Yes+262
0.5u
With Chambliss at QB, Lane will implement a ton of designed run using TE motion blockers. Expect Wright to be a top option in red zone after Chambliss has half dozen designed runs
Dan Gaspar
Dan Gaspar
Last 30d: 55-54-2 (-6.4u)
D.Alexander u46.5 Rec Yds-115
1.15u
Mjaybrod
Mjaybrod
Last 30d: 134-110-0 (+29.7u)
LSU o27.5 Team Total-105
1u
Nobody likes this LSU offense
Sandy Plashkes
Sandy Plashkes
Last 30d: 115-129-6 (-19.8u)
Over 54.5-110
1.1u
Tailing Lane Kiffen
Boomer Betz
Boomer Betz
Last 30d: 210-191-11 (+28.7u)
Under 54.5-107
0.93u
Cam Is Money
Cam Is Money
Last 30d: 110-107-2 (-3.4u)
Over 54.5-105
1u
Ryan Sura
Ryan Sura
Last 30d: 49-60-0 (-15.4u)
LSU -110
1.1u
Collin Wilson
Collin Wilson
Last 30d: 83-63-0 (+13.8u)
LSU -113
1.13u
From BBOC SEC Preview; LSU Nussmeier and elite stable of WRs to take on a depleted Ole Miss secondary. Tigers get SELA W4 while Ole Miss faces Tulane

LSU vs. Ole Miss Previews & Analysis

  • Smart Bets for Tonight's 2 Headliners article feature image

    Smart Bets for Tonight's 2 Headliners

    Alex Kolodziej•
    Sep 27, 2025 UTC
  • 3 Live Dogs Form High-Upside 38-1 Parlay article feature image

    3 Live Dogs Form High-Upside 38-1 Parlay

    Alex Kolodziej•
    Sep 27, 2025 UTC
  • Your Week 5 NCAAF Betting Cheat Sheet article feature image

    Your Week 5 NCAAF Betting Cheat Sheet

    Pete Ruden•
    Sep 27, 2025 UTC
  • Our Staff Picks for #13 Ole Miss vs. #4 LSU article feature image

    Our Staff Picks for #13 Ole Miss vs. #4 LSU

    Action Network Staff•
    Sep 27, 2025 UTC
See more NCAAF Coverage Right Arrow

Prop Odds Comparison

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No props found

Line Movement Tracker

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LSU vs. Ole Miss Public Betting Percentages

Away Logo

LSU

Public

Home Logo

Ole Miss

62%

Bets%

38%

Money%

NCAAF Public Betting Right Arrow

Betting Trends

  • Ole Miss are 5-0 in their last 5 games.
  • Ole Miss are 2-3 in their last 5 games against the spread
  • Ole Miss are 1-2 in their road games against the spread
  • The totals have gone OVER in 4 of Ole Miss' last 5 games
  • The totals have gone OVER in 3 of Ole Miss' 8 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Ole Miss		6-55-31-25-31-1
LSU		3-72-41-32-21-4

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Ole Miss		6-53-53-04-42-0
LSU		3-72-41-30-42-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Ole Miss		10-1N/AN/A8-01-1
LSU		6-4N/AN/A4-01-4

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 20thTULNW 45-10-12.5 WU 61.5MISS -440
Sep 13thARKW 41-35-3.5 WO 60MISS -172
Sep 6th@UKW 30-23-8.5 LO 50.5MISS -345
Aug 30thGASTW 63-7-33.5 WO 60.5MISS -15000
Jan 3rdDUKEW 52-20-18.5 WO 51.5MISS -1000
Team Stats

Total

254
Total Yards
480
56
Total Plays
84
4.535714285714286
Yards Per Play
5.714285714285714

Passing

197
YDS
314
21/34
Comps/Atts
23/39
5.794117647058823
YPA
8.051282051282051
1/1
TDs/INTs
1/1
1/8
Sacks/Yards
0/0

Rushing

57
Rush Yards
166
22
Attempts
45
2.590909090909091
YPC
3.688888888888889
1
TDs
2

Turnovers

0
Fumbles Lost
1
1
Interceptions
1

Efficiency

2/2 100%
Redzone
4/5 80%
2/11 0%
3rd Down
8/16 0%
2/2 0%
4th Down
2/2 0%

First Downs

16
Total
28
8
Pass
14
5
Rush
10
3
Penalty
4

Misc

7/78
Penalties/Yards
14/109

LSU vs. Ole Miss Odds Comparison

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LSU at Ole Miss Team Totals

MatchupOverUnder
LSU
6-4
o27.5-122
u27.5-108
Ole Miss
10-1
o30.5-112
u30.5-117