Cardinals vs. Mustangs Odds & Betting Predictions - November 22, 2025

Cardinals at Mustangs

5:00 pm • ESPN2

Louisville Cardinals

9-4

6 - 38

SMU Mustangs

9-4

MatchupOpenSpreadTotalMoneyline
Cardinals 9-4	+3.5	+3.5-105	o49.5-110	+154
Mustangs 9-4	u49.5	-3.5-110	u49.5-110	-190

Saturday 5:00 p.m.

November 22, 2025

Gerald J. Ford StadiumDallas

SMU -104 (Live)

1.35u

Discord bet

SMU -2.5 (Live)-115

SMU -3-115

0.87u

Link in Bio for early access

LOU +4.5-110

1.1u

LOU +4-110

1.1u

LOU +130 (1H)

0.5u

2.56% ev

SMU -2.5-110

$1.00

SMU -3-102

0.98u

@_Collin1 https://myaction.app/froqdThRtYb

LOU +4-110

0.35u

SMU -3-110

Project SMU -3.5; great situational spot, Louisville on back to back losses and off Clemson w Kentucky rivalry on deck. SMU off a bye week

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Nov 22, 2025 UTC
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Collin Wilson•
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See more NCAAF Coverage

No props found

NCAAF Public Betting

Mustangs are 5-0 in their last 5 games.
Mustangs are 3-2 in their last 5 games against the spread
Mustangs are 2-4 in their road games against the spread
The totals have gone OVER in 0 of Mustangs' last 5 games
The totals have gone OVER in 1 of Mustangs' 6 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Mustangs	5-7	3-3	2-4	3-5	2-1
Cardinals	4-8	1-7	3-1	2-7	2-1

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Mustangs	4-8	1-5	3-3	3-5	1-2
Cardinals	5-7	4-4	1-3	5-4	0-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Mustangs	8-4	N/A	N/A	5-3	2-1
Cardinals	8-4	N/A	N/A	6-3	2-1

date	opponent	score	spread	over/under	moneyline
Nov 8th	@BC	W 45-13	-10.5 W	O 54.5	SMU -425
Nov 1st	MIA	W 26-20	+8.5 W	U 50.5	SMU +260
Oct 25th	@WF	L 12-13	-5.5 L	U 52.5	WF -210
Oct 18th	@CLEM	W 35-24	+3.5 W	O 49.5	SMU +146
Oct 11th	STAN	W 34-10	-19.5 W	U 55.5	SMU -1100

Cardinals

Total

Mustangs

228

Total Yards

485

Total Plays

4.653061224489796

Yards Per Play

6.554054054054054

Cardinals

Passing

Mustangs

100

YDS

307

14/20

Comps/Atts

30/38

YPA

8.078947368421053

0/1

TDs/INTs

3/0

2/10

Sacks/Yards

1/12

Cardinals

Rushing

Mustangs

128

Rush Yards

178

Attempts

4.413793103448276

YPC

4.944444444444445

TDs

Cardinals

Turnovers

Mustangs

Fumbles Lost

Interceptions

Cardinals

Efficiency

Mustangs

2/2 100%

Redzone

4/4 100%

3/12 0%

3rd Down

9/13 0%

0/0 0%

4th Down

0/0 0%

Cardinals

First Downs

Mustangs

Total

Pass

Rush

Penalty

Cardinals

Misc

Mustangs

6/47

Penalties/Yards

7/70

Could not load odds

See more NCAAF Odds

MatchupOverUnder
Cardinals 9-4	N/A	N/A
Mustangs 9-4	N/A	N/A

Cardinals vs. Mustangs Odds & Betting Predictions - November 22, 2025

Cardinals at Mustangs

Louisville Cardinals

SMU Mustangs

Cardinals at Mustangs Odds

Spread, Total, Moneyline

Cardinals vs. Mustangs Previews & Analysis

Our CFB Best Bets For Saturday's Noon Slate

Your Week 13 NCAAF Betting Cheat Sheet

'Line Freeze' Model: 3 No-Doubt Sharp Sides

SMU vs Louisville: Collin's Pick

Prop Odds Comparison

Line Movement Tracker

Cardinals vs. Mustangs Public Betting Percentages

Cardinals

Public

Mustangs

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

Cardinals vs. Mustangs Odds Comparison

Cardinals at Mustangs Team Totals