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SMU vs. Clemson Odds & Betting Predictions - October 18, 2025

SMU at Clemson

7:30 pm • ACC Network

SMU Mustangs

5-3
35
35 - 24

Clemson Tigers

3-4
24

SMU at Clemson Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
SMU
5-3
+11.5
+3.5-110
o49.5-112
+146
Clemson
3-4
u55.5
-3.5-110
u49.5-110
-180
location pinSaturday 7:30 p.m.
October 18, 2025
Memorial Stadium (Clemson, SC)Clemson
SMU vs. Clemson Expert Picks
Picks Office
Picks Office
Last 30d: 137-113-4 (+16.3u)
SMU +4.5-105
0.95u
X: PicksOffice
YBK Picks.com
Last 30d: 60-44-1 (+27.0u)
SMU +3.5-105
2.86u
Collin Wilson
Collin Wilson
Last 30d: 93-75-1 (+15.3u)
CLEM u29 Team Total-111
0.5u
SMU +7-110
1u
Babs .
Babs .
Last 30d: 105-112-3 (-4.9u)
CLEM -8.5-110
1u

SMU vs. Clemson Previews & Analysis

  • SMU vs. Clemson: A Bit of Value on Road 'Dog article feature image

    SMU vs. Clemson: A Bit of Value on Road 'Dog

    Action Network Staff•
    Oct 18, 2025 UTC
  • Our CFB Best Bets For Saturday Afternoon article feature image

    Our CFB Best Bets For Saturday Afternoon

    Action Network Staff•
    Oct 18, 2025 UTC
  • Your Week 8 NCAAF Betting Cheat Sheet article feature image

    Your Week 8 NCAAF Betting Cheat Sheet

    Pete Ruden•
    Oct 18, 2025 UTC
  • USC vs. Notre Dame Picks & More College Football Best Bets! | Big Bets On Campus LIVE! article feature image

    USC vs. Notre Dame Picks & More College Football Best Bets! | Big Bets On Campus LIVE!

    •
    Oct 17, 2025 UTC
See more NCAAF Coverage Right Arrow

Prop Odds Comparison

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No props found

Line Movement Tracker

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SMU vs. Clemson Public Betting Percentages

Away Logo

SMU

Public

Home Logo

Clemson

57%

Bets%

43%

Money%

NCAAF Public Betting Right Arrow

Betting Trends

  • Clemson are 1-4 in their last 5 games.
  • Clemson are 0-5 in their last 5 games against the spread
  • Clemson are 2-1 in their road games against the spread
  • The totals have gone OVER in 3 of Clemson' last 5 games
  • The totals have gone OVER in 3 of Clemson' 5 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Clemson		2-60-52-12-6N/A
SMU		3-62-31-31-42-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Clemson		4-43-21-24-4N/A
SMU		2-71-41-31-41-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Clemson		3-5N/AN/A3-5N/A
SMU		6-3N/AN/A3-22-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Oct 11th@BCW 41-10-14 WU 54.5CLEM -590
Oct 4th@UNCW 38-10-15.5 WO 47.5CLEM -720
Sep 20thSYRL 21-34-17.5 LO 53.5SYR -900
Sep 13th@GTL 21-24-3 LU 50.5GT -145
Sep 6thTROYW 27-16-30.5 LU 51.5CLEM -11946
Team Stats

Total

429
Total Yards
352
71
Total Plays
72
6.042253521126761
Yards Per Play
4.888888888888889

Passing

290
YDS
317
23/43
Comps/Atts
29/42
6.744186046511628
YPA
7.5476190476190474
2/1
TDs/INTs
3/0
1/5
Sacks/Yards
4/17

Rushing

139
Rush Yards
35
28
Attempts
30
4.964285714285714
YPC
1.1666666666666667
2
TDs
0

Turnovers

0
Fumbles Lost
1
1
Interceptions
0

Efficiency

3/3 100%
Redzone
2/2 100%
7/17 0%
3rd Down
8/19 0%
0/0 0%
4th Down
1/2 0%

First Downs

21
Total
20
12
Pass
16
8
Rush
2
1
Penalty
2

Misc

5/60
Penalties/Yards
2/9

SMU vs. Clemson Odds Comparison

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SMU at Clemson Team Totals

MatchupOverUnder
SMU
5-3
o22.5-122
u22.5-109
Clemson
3-4
o26.5-125
u26.5-106