Louisville vs. Michigan St Odds & Betting Predictions - March 21, 2026
Louisville at Michigan St
6:48 pm • CBSLouisville at Michigan St Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 Louisville 23-10 | +3.5 | +5.5-111 | o151.5-110 | +200 |
 Michigan St 25-7 | u150.5 | -5.5-109 | u151.5-110 | -245 |
KeyBank CenterBuffalo
Louisville vs. Michigan St Expert Picks
John Feltman
Last 30d: 6-13-1 (-4.8u)
LOU +9.5 (Live)-115
0.5u
Stuck 🚨
Last 30d: 11-21-0 (-0.5u)
LOU +9.5 (Live)-110
0.14u
Good time to get in. 55-15 3P% after Cowell foul trouble. 7+ good
New Owner
Last 30d: 74-85-0 (+10.1u)
Under 71 (1H)-105
$100.00
Supposed to be to win $50
Sandy Plashkes
Last 30d: 113-105-3 (+13.0u)
R.Conwell o19.5 Pts-108
1u
@sushibet
Allan Lem
Last 30d: 57-39-0 (+5.2u)
LOU +5.5-115
0.58u
Tailing @The_Oddsmaker
Vegas Refund
Last 30d: 8-7-0 (+0.3u)
LOU +5.5-110
1.1u
Gilles Gallant
Last 30d: 37-24-0 (+6.1u)
LOU +5.5-115
0.58u
#Tailing @The_Oddsmaker
Wags Wins
Last 30d: 212-246-2 (-22.6u)
Under 152.5-115
1.09u
CTO
Last 30d: 0-0-0 (+0.0u)
MSU -4.5-110
2.73u
Sean Koerner
Last 30d: 52-49-1 (+5.8u)
LOU +5.5-115
0.58u
Mjaybrod
Last 30d: 27-34-0 (-5.3u)
LOU +5.5-110
1u
Gotta do it
Collin Whitchurch
Last 30d: 92-172-7 (+2.8u)
LOU +5.5-115
0.29u
YBK Picks.com
Last 30d: 27-31-3 (-13.3u)
LOU +4.5-105
2u
Sandy Plashkes
Last 30d: 113-105-3 (+13.0u)
Under 152-110
1u
RoyalsProps
Last 30d: 64-54-6 (+5.0u)
R.Conwell o19.5 Pts+100
1u
Brian Bitler
Last 30d: 76-72-1 (+8.9u)
LOU +3.5+117
3u
💰🦡 Jake
Last 30d: 66-73-1 (+0.6u)
MSU -2.5 (1H)-110
2u
Sean Zerillo
Last 30d: 161-157-12 (-7.6u)
LOU +5-110
0.55u
JMann
Last 30d: 2-3-0 (-1.2u)
MSU -4.5-110
1.36u
Under 151.5-110
0.91u
Sean Paul
Last 30d: 15-13-1 (+1.4u)
MSU -4.5-110
0.91u
Babs .
Last 30d: 13-19-0 (-6.8u)
Under 151.5-110
0.91u
John Lanfranca
Last 30d: 2-7-1 (-5.0u)
MSU -4-110
0.5u
Babs .
Last 30d: 13-19-0 (-6.8u)
MSU -4.5-110
0.91u
Brandon Kravitz
Last 30d: 84-102-1 (-14.6u)
MSU -4.5-105
0.5u
Mike McNamara
Last 30d: 29-48-0 (-1.9u)
MSU -178
0.45u
Doug Ziefel
Last 30d: 283-377-23 (-23.1u)
LOU +170
0.29u
LOU +4.5-110
0.55u
Nick Giffen
Last 30d: 12-33-0 (+0.7u)
LOU +170
0.4u
Giffen Guide to March Madness: https://www.actionnetwork.com/ncaab/nick-giffens-moneyline-rollover-picks-2026-guide-march-madness
Louisville vs. Michigan St Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Louisville vs. Michigan St Public Betting Percentages
Betting Trends
- Michigan St are 3-2 in their last 5 games.
- Michigan St are 3-2 in their last 5 games against the spread
- Michigan St are 7-4 in their road games against the spread
- The totals have gone OVER in 4 of Michigan St' last 5 games
- The totals have gone OVER in 9 of Michigan St' 21 last games at home
Matchup History
Against the Spread (ATS) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 16-16 | 9-12 | 7-4 | 12-13 | 4-2 |
| 15-18 | 9-9 | 6-9 | 11-13 | 1-3 |
Over/Under History
| overall | home o/u | away o/u | favorite o/u | underdog o/u | |
|---|---|---|---|---|---|
| 15-17 | 9-12 | 6-5 | 12-13 | 3-3 |
| 12-21 | 5-13 | 7-8 | 9-15 | 1-3 |
Straight-Up (ML) History
| overall | home | away | favorite | underdog | |
|---|---|---|---|---|---|
| 25-7 | N/A | N/A | 22-3 | 2-4 |
| 23-10 | N/A | N/A | 17-7 | 1-3 |
Last 5 Matchups
Team Stats
26-63 (41%)
Field Goals
26-55 (47%)
4-6 (67%)
Free Throws
14-19 (74%)
13-37 (35%)
3P
11-26 (42%)
29
Rebounds
34
16
Assists
22
10
Turnovers
14
5
Steals
4
2
Blocks
5
21
Fouls
11
Louisville vs. Michigan St Odds Comparison
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Louisville at Michigan St Team Totals
MatchupOverUnder | ||
|---|---|---|
Louisville 23-10 | N/A | N/A |
Michigan St 25-7 | N/A | N/A |