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Louisville vs. Michigan St Odds & Betting Predictions - March 21, 2026

Louisville at Michigan St

6:48 pm • CBS

Louisville Cardinals

23-10
69
69 - 77

Michigan State Spartans

25-7
77

Louisville at Michigan St Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Louisville
23-10
+3.5
+5.5-111
o151.5-110
+200
Michigan St
25-7
u150.5
-5.5-109
u151.5-110
-245
location pinSaturday 6:48 p.m.
March 21, 2026
KeyBank CenterBuffalo
Louisville vs. Michigan St Expert Picks
John Feltman
John Feltman
Last 30d: 59-56-1 (-2.3u)
LOU +9.5 (Live)-115
0.5u
Stuck 🚨
Stuck 🚨
Last 30d: 64-77-4 (+0.1u)
LOU +9.5 (Live)-110
0.14u
Good time to get in. 55-15 3P% after Cowell foul trouble. 7+ good
Boomer Betz
Boomer Betz
Last 30d: 123-100-4 (+40.2u)
Under 71 (1H)-105
$100.00
Supposed to be to win $50
Sandy Plashkes
Sandy Plashkes
Last 30d: 124-128-4 (-17.4u)
R.Conwell o19.5 Pts-108
1u
@sushibet
Allan Lem
Allan Lem
Last 30d: 118-87-2 (+7.6u)
LOU +5.5-115
0.58u
Tailing @The_Oddsmaker
Vegas Refund
Vegas Refund
Last 30d: 72-70-1 (-4.9u)
LOU +5.5-110
1.1u
Gilles Gallant
Gilles Gallant
Last 30d: 43-56-1 (-4.5u)
LOU +5.5-115
0.58u
#Tailing @The_Oddsmaker
Wags Wins
Wags Wins
Last 30d: 274-243-2 (+44.6u)
Under 152.5-115
1.09u
CTO
CTO
Last 30d: 25-28-0 (-1.8u)
MSU -4.5-110
2.73u
Sean Koerner
Sean Koerner
Last 30d: 31-39-2 (-2.6u)
LOU +5.5-115
0.58u
Mjaybrod
Mjaybrod
Last 30d: 91-78-1 (+7.2u)
LOU +5.5-110
1u
Gotta do it
YBK Picks.com
Last 30d: 34-24-0 (+3.7u)
LOU +4.5-105
2u
Sandy Plashkes
Sandy Plashkes
Last 30d: 124-128-4 (-17.4u)
Under 152-110
1u
Royals Props
Royals Props
Last 30d: 33-34-0 (-6.1u)
R.Conwell o19.5 Pts+100
1u
Brian Bitler
Brian Bitler
Last 30d: 81-93-1 (-41.6u)
LOU +3.5+117
3u
💰🦡 Jake
💰🦡 Jake
Last 30d: 70-83-1 (-2.9u)
MSU -2.5 (1H)-110
2u
Sean Zerillo
Sean Zerillo
Last 30d: 91-97-1 (+11.6u)
LOU +5-110
0.55u
JMann
JMann
Last 30d: 48-50-0 (+2.8u)
MSU -4.5-110
1.36u
Under 151.5-110
0.91u
Sean Paul
Sean Paul
Last 30d: 30-37-0 (-7.6u)
MSU -4.5-110
0.91u
Babs .
Babs .
Last 30d: 115-88-0 (+14.5u)
Under 151.5-110
0.91u
John Lanfranca
John Lanfranca
Last 30d: 9-8-0 (+1.1u)
MSU -4-110
0.5u
Babs .
Babs .
Last 30d: 115-88-0 (+14.5u)
MSU -4.5-110
0.91u
Brandon Kravitz
Brandon Kravitz
Last 30d: 72-91-0 (-8.1u)
MSU -4.5-105
0.5u
Mike McNamara
Mike McNamara
Last 30d: 107-137-2 (+4.1u)
MSU -178
0.45u
Doug Ziefel
Doug Ziefel
Last 30d: 142-154-3 (-10.0u)
LOU +170
0.29u
LOU +4.5-110
0.55u
Nick Giffen
Nick Giffen
Last 30d: 46-81-0 (+7.5u)
LOU +170
0.4u
Giffen Guide to March Madness: https://www.actionnetwork.com/ncaab/nick-giffens-moneyline-rollover-picks-2026-guide-march-madness

Louisville vs. Michigan St Previews & Analysis

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  • Model-Based Total Highlights Our Saturday NCAA Tourney Best Bets article feature image

    Model-Based Total Highlights Our Saturday NCAA Tourney Best Bets

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    McGrath's Projected Scores for Every NCAA Tournament Second-Round Matchup

    Tanner McGrath•
    Mar 21, 2026 UTC
See more NCAAB Coverage Right Arrow

Prop Odds Comparison

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No props found

Line Movement Tracker

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Louisville vs. Michigan St Public Betting Percentages

Away Logo

Louisville

Public

Home Logo

Michigan St

38%

Bets%

62%

Money%

NCAAB Public Betting Right Arrow

Betting Trends

  • Michigan St are 3-2 in their last 5 games.
  • Michigan St are 3-2 in their last 5 games against the spread
  • Michigan St are 7-4 in their road games against the spread
  • The totals have gone OVER in 4 of Michigan St' last 5 games
  • The totals have gone OVER in 9 of Michigan St' 21 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Michigan St		16-169-127-412-134-2
Louisville		15-189-96-911-131-3

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Michigan St		15-179-126-512-133-3
Louisville		12-215-137-89-151-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Michigan St		25-7N/AN/A22-32-4
Louisville		23-10N/AN/A17-71-3

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Mar 19thNDSUW 92-67-16.5 WO 144.5MSU -1650
Mar 14thUCLAL 84-88-5.5 LO 141.5UCLA -235
Mar 8th@MICHL 80-90+10.5 WO 152.5MICH +412
Mar 6thRUTGW 91-87-19.5 LO 142.5MSU -3743
Mar 1st@INDW 77-64-3 WU 144.5MSU -170

Louisville vs. Michigan St Injury Updates

Louisville Injuries

    Michigan St Injuries

    • Kaleb Glenn
      F

      Glenn is out for season with knee

      Out for Season

    • Divine Ugochukwu
      G

      Ugochukwu is out for season with foot

      Out for Season

    See more NCAAB Injuries Right Arrow
    Team Stats

    26-63 (41%)
    Field Goals
    26-55 (47%)
    4-6 (67%)
    Free Throws
    14-19 (74%)
    13-37 (35%)
    3P
    11-26 (42%)
    29
    Rebounds
    34
    16
    Assists
    22
    10
    Turnovers
    14
    5
    Steals
    4
    2
    Blocks
    5
    21
    Fouls
    11

    Louisville vs. Michigan St Odds Comparison

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    Could not load odds

    See more NCAAB Odds Right Arrow

    Louisville at Michigan St Team Totals

    MatchupOverUnder
    Louisville
    23-10
    N/A
    N/A
    Michigan St
    25-7
    N/A
    N/A