Patriots vs. 49ers Odds & Betting Predictions - September 29, 2024
Patriots at 49ers
8:05 pm • FOXPatriots at 49ers Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
---|---|---|---|---|
![]() Patriots 0-0 | +9 | +10.5-110 | o42.5-106 | +425 |
![]() 49ers 0-0 | u45 | -10.5-110 | u42.5-112 | -550 |

Levi's StadiumSanta Clara
Patriots vs. 49ers Expert Picks

Shady Biev
Last 30d: 18-18-0 (+2.8u)
Under 42.5 (Live)-105
1.58u

Action Network Luck Rankings
Last 30d: 9-6-0 (+2.2u)
Over 42-110
0.91u

Shady Biev
Last 30d: 18-18-0 (+2.8u)
R.Stevenson Anytime TD Scorer Yes+140
1.5u

Dale Tanhardt
Last 30d: 3-6-0 (-1.8u)
G.Kittle Anytime TD Scorer Yes+210
2.52u

Brian Condon
Last 30d: 9-17-0 (+1.5u)
SF -10.5-110
0.91u
- Keeping this one simple. Big favorites have had the worst 3 weeks in the past 20 years against the spread.
- I love for the biggest favorite of the week to cover with ease this week

Chris Raybon
Last 30d: 0-1-0 (-1.0u)
D.Samuel u4.5 Recs-120
0.83u
Potential to be eased in/decoy returning from calf early as big home fav for SF team also getting Kittle back. Was under 4.5 in 5 straight after his first injury in '23. Under 4.5 in 11 of last 17 dating back to Week 4 '23.

Steak Friend
Last 30d: 0-0-0 (+0.0u)
NE +10.5-110
1.1u

Greg DiNardo
Last 30d: 2-3-0 (-1.3u)
SF -10.5-110
1u

Brian Bitler
Last 30d: 90-80-0 (+20.3u)
NE +10.5-110
3u
Gilles Gallant
Last 30d: 1-5-0 (-2.3u)
D.Douglas Anytime TD Scorer Yes+550
0.5u

Firefighter Bets
Last 30d: 73-66-0 (+3.0u)
J.Tavai o7.5 Tackles + Ast+105
1u

Grant Neiffer
Last 30d: 41-110-7 (+33.4u)
B.Aiyuk o61.5 Rec Yds-115
1.15u
H.Henry o26.5 Rec Yds-118
1.18u

Cam Is Money
Last 30d: 55-84-3 (-26.0u)
B.Purdy o6.5 Rush Yds-123
0.81u

Moneyline Hacks
Last 30d: 91-78-3 (+4.1u)
B.Purdy o6.5 Rush Yds-115
1.3u
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Mjaybrod
Last 30d: 8-14-0 (-6.7u)
SF -10.5-110
0.91u
Buying low with a banged up SF team

Moneyline Hacks
Last 30d: 91-78-3 (+4.1u)
NE +10.5-110
0.5u
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Picks Office
Last 30d: 79-76-4 (+1.7u)
Under 39.5-110
1u
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Despite a promising start with a win against the Bengals, the Patriots' offense has since fallen flat, scoring only 13 points per game, ranking 31st in the league. The offensive line's issues have left Jacoby Brissett under heavy pressure, impacting the team's ability to move the ball effectively. In their most recent matchup against the Jets, New England managed just three points, with Brissett throwing for only 98 yards. Their running game wasn’t any better, with Antonio Gibson and Rhamondre Stevenson combining for a mere 52 rushing yards. With such poor offensive production, it’s hard to see the Patriots suddenly breaking out against a 49ers defense, even one that’s been somewhat inconsistent to start the year.
San Francisco is also dealing with the absence of key offensive weapon Christian McCaffrey, which should limit their own scoring upside. Although their defense hasn't been at its best so far, they showed last season that they are capable of turning it around, and facing a Patriots offense that has been unable to find any rhythm presents the perfect opportunity to get back on track. New England’s defense, meanwhile, has been solid, ranked 10th in the league and giving up only 19 points per game. With the Patriots' defensive unit capable of keeping them in games, this sets up a lower-scoring affair, especially given how poorly their offense has performed.
The combination of the Patriots’ anemic offense, the 49ers’ injury concerns, and both teams’ potential to control the pace of the game through defense makes the Under an attractive pick. Expect the scoring to remain low, with neither team lighting up the scoreboard in this matchup.

Jim Sannes
Last 30d: 12-30-0 (+4.0u)
Over 39.5-110
0.91u
My model is always on the over in 49ers games, and this is no different. They still clicked Sunday without CMC/Deebo/Kittle, and Javon Hargrave won't play, which could help the Patriots' offense.
PRO Insights

Patriots
NE Insights
- Featured Insight
The Patriots have allowed successful plays on 41.0% of rush attempts with a light front since the 2023 season -- T-7th-best in NFL; the 49ers have run successful plays on 20.0% of rush attempts against a light front since the 2023 season -- T-worst in NFL.
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49ers
SF Insights
- Featured Insight
49ers QBs have a 109.4 passer rating when scrambling this season -- 4th-best in NFL; the Patriots have allowed a passer rating of 118.8 when the opposing QB was scrambling this season -- 2nd-worst in NFL.
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49ers vs. Patriots Injury Updates

49ers Injuries
- Trevis GipsonLB
Gipson is out with ankle
Out

Patriots Injuries
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Patriots vs. 49ers Odds Comparison
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Patriots at 49ers Team Totals
MatchupOverUnder | ||
---|---|---|
![]() Patriots 0-0 | o14.5-115 | u14.5-105 |
![]() 49ers 0-0 | o26.5-118 | u26.5+102 |