USC vs. Oregon Odds & Betting Predictions - November 22, 2025

Completely disagree with the Oregon money here. USC was getting this same number at ND in a game where they still covered in despite turning the ball over 3 times. That’s with market inflation of Riley being bad outside the west coast as well. Have ND graded above Oregon and on the surface not the best matchup in the world but think Oregon has benefited from schedule a bit in terms of passing defense numbers. However Oregon’s pass rush is not elite by any means, being graded out in the bottom half of the Big Ten, and that’s how u beat Maiava(133.1 Passer Rating when Clean compared to just a 42.8 when pressured). Don’t think Oregon will be able to exploit Maiava crumbling under pressure enough. Had this spot circled as this is USC’s Super Bowl with 2 losses. Also fwiw lookahead at FD just a week ago was sitting at Oregon -6.5, i know that market isn’t as efficient but this line going up to 10.5 for basically no reason is just too much love to an Oregon team that has underwhelmed us in all 3 big games they’ve played