Cardinals vs. Guardians Odds & Betting Predictions - June 27, 2025

Cardinals at Guardians

11:10 pm • Apple TV+

St. Louis Cardinals

30-25

5 - 0

Cleveland Guardians

34-25

pitcher		team	era	w-l
L.Ortiz			4.37	4-9
S.Gray			4.28	14-8

MatchupOpenSpreadTotalMoneyline
Cardinals 30-25	-1.5	-1.5+133	o8.5-111	-127
Guardians 34-25	u8.5	+1.5-162	u8.5-107	+106

Friday 11:10 p.m.

June 27, 2025

Progressive FieldCleveland

Under 8.5-105

0.48u

Backing Sonny Gray and Luis Ortiz, both of whom have solid underlying metrics. Gray has a 3.19 FIP and 3.11 xFIP with a career-low 4.9% walk rate. Ortiz with a 3.98 FIP and 3.64 xFIP with a career high 25.7% K%. Guardians also rolling out a more watered-down lineup without Jose Ramirez and Carlos Santana. Both teams have league-average bullpens so that’s why I’m willing to go the full total over the F5. Projecting this closer to 8.

CLE +110

Follow @PicksOffice on X for more

Under 0.5 (1st Inn)-115

Under 8.5-104

STL -120

0.5u

S.Gray o5.5 Ks-120

0.83u

STL -120

STL -130

0.77u

Under 8.5-108

S.Gray o5.5 Ks-130

L.Ortiz o4.5 Ks-115

CLE +110

0.5u

Bet to +103

Over 8.5+100

0.5u

Bet to 9 (-105)

Under 8.5-112

0.5u

Negative run environment - Gray 3.24 SIERA/3.99 xERA (sets up well against him, being better vs LHBs this year) - CLE 95/97 wRC+ Hm/v RHP - Both top defenses

Our 4 MLB Best Bets & Parlay for Friday
Action Network Staff•
Jun 27, 2025 UTC
2 MLB NRFI & YRFI Picks for Friday
Billy Ward•
Jun 27, 2025 UTC
Cardinals vs. Guardians: Bounce-Back Spot
Action Network Staff•
Jun 27, 2025 UTC
2 PRO Systems Agree on Friday Pick
Alex Kolodziej•
Jun 26, 2025 UTC

See more MLB Coverage

No props found

MLB Public Betting

Guardians are 3-2 in their last 5 games.
Guardians are 1-4 in their last 5 games against the spread
Guardians are 15-15 in their road games against the spread
The totals have gone OVER in 2 of Guardians' last 5 games
The totals have gone OVER in 14 of Guardians' 29 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Guardians	31-28	16-13	15-15	17-18	14-10
Cardinals	33-22	16-11	17-11	3-3	30-19

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Guardians	28-31	14-15	14-16	17-18	11-13
Cardinals	24-28-3	14-12-1	10-16-2	2-4	22-24-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Guardians	34-25	17-12	17-13	21-14	13-11
Cardinals	30-25	14-13	16-12	3-3	27-22

date	opponent	score	spread	over/under	moneyline
Jun 26th	TOR	L 0-6	-1.5 L	U 7.5	TOR -136
Jun 25th	TOR	W 5-4	-1.5 L	O 8	CLE -125
Jun 24th	TOR	L 6-10	+1.5 L	O 9	TOR +112
Jun 22nd	@ATH	W 3-0	-1.5 W	U 9	CLE -113
Jun 22nd	@ATH	W 4-2	-1.5 W	U 9.5	CLE -135

Lars Nootbaar
LF
Nootbaar is out with heel
Out

See more MLB Injuries

PITCHER		PC	IP	K	ER
RS.Gray, P		89	9	11	0

HITTERS	H-AB	R	HR	RBI
1B.Donovan, 2B	1-4	0	0	0
2M.Winn, SS	0-4	1	0	0
3A.Burleson, RF	2-4	2	1	2
3G.Hampson, RF	0-0	0	0	0
4W.Contreras, 1B	1-3	1	0	0
5L.Nootbaar, LF	0-3	0	0	0
6N.Arenado, 3B	2-4	0	0	2
7N.Gorman, DH	0-4	0	0	0
8P.Pages, C	1-4	1	1	1
9V.Scott, CF	0-4	0	0	0

PITCHER	PC	IP	K	ER
RL.Ortiz, P	102	7	5	4
RJ.Junis, P	27	1	1	1
LE.Sabrowski, P	10	1	2	0

HITTERS	H-AB	R	HR	RBI
1S.Kwan, LF	0-4	0	0	0
2L.Thomas, CF	0-3	0	0	0
3K.Manzardo, 1B	0-3	0	0	0
4D.Fry, DH	0-3	0	0	0
5D.Schneemann, 3B	0-3	0	0	0
6N.Jones, RF	1-3	0	0	0
7G.Arias, SS	0-3	0	0	0
8B.Naylor, C	0-3	0	0	0
9A.Martinez, 2B	0-3	0	0	0