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Guardians vs. Athletics Odds & Betting Predictions - June 22, 2025

Guardians at Athletics

2:05 am • NBCS-CA

Cleveland Guardians

67-66
4
4 - 2

Athletics

63-73
2
Starting Pitchers
pitcherteameraw-l
Mitch Spence logoM.SpenceAthletics logo4.702-5
Luis L. Ortiz logoL.OrtizCleveland Guardians logo4.374-9

Guardians at Athletics Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Guardians
67-66
-1.5
-1.5+118
o9.5+101
-135
Athletics
63-73
u9.5
+1.5-143
u9.5-123
+114
location pinSunday 2:05 a.m.
June 22, 2025
Sutter Health ParkWest Sacramento
Guardians vs. Athletics Expert Picks
Cam Is Money
Cam Is Money
Last 30d: 68-87-3 (-15.8u)
Over 9.5-103
2u
Kyle Murray
Kyle Murray
Last 30d: 30-39-1 (-3.1u)
M.Spence o4.5 Ks+106
1u
Grant Neiffer
Grant Neiffer
Last 30d: 39-102-5 (+30.1u)
N.Kurtz o0.5 HR+450
0.25u
Picks Office
Picks Office
Last 30d: 78-73-3 (+5.0u)
CLE -120
0.83u
Follow @PicksOffice on X to read the full writeup.
Boomer Betz
Boomer Betz
Last 30d: 199-216-1 (-40.5u)
M.Spence o2.5 Earned Runs+117
1.17u
Sean Zerillo
Sean Zerillo
Last 30d: 180-182-3 (+6.0u)
ATH +104
0.5u
Bet to -110

Guardians vs. Athletics Previews & Analysis

  • Guardians vs. Athletics: The PRO Model Play article feature image

    Guardians vs. Athletics: The PRO Model Play

    Alex Kolodziej•
    Jun 21, 2025 UTC
  • Neiffer's Home Run Prop Bets for Saturday article feature image

    Neiffer's Home Run Prop Bets for Saturday

    Grant Neiffer•
    Jun 21, 2025 UTC
See more MLB Coverage Right Arrow

Prop Odds Comparison

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No props found

Line Movement Tracker

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Guardians vs. Athletics Public Betting Percentages

Away Logo

Guardians

Public

Home Logo

Athletics

54%

Bets%

46%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Athletics are 3-2 in their last 5 games.
  • Athletics are 3-2 in their last 5 games against the spread
  • Athletics are 41-28 in their road games against the spread
  • The totals have gone OVER in 3 of Athletics' last 5 games
  • The totals have gone OVER in 34 of Athletics' 67 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Athletics		73-6332-3541-2812-1859-43
Guardians		68-6531-3537-3028-2940-34

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Athletics		67-62-734-31-233-31-514-14-251-46-5
Guardians		59-68-633-30-326-38-330-26-128-41-5

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Athletics		63-7329-3834-3514-1646-56
Guardians		67-6634-3233-3435-2232-42

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jun 21stCLEW 5-1+1.5 WU 9ATH +105
Jun 20thHOUW 6-4+1.5 WU 10ATH +122
Jun 19thHOUL 4-11+1.5 LO 9.5HOU +152
Jun 18thHOUL 3-13+1.5 LO 11HOU +107
Jun 17thHOUW 3-1+1.5 WU 9.5ATH -106

Guardians vs. Athletics Injury Updates

Guardians Injuries

  • Ben Lively
    SP

    Lively is out with elbow

    Out

  • John Means
    SP

    Means is out with elbow

    Out

Athletics Injuries

  • Luis Medina
    SP

    Medina is out with elbow

    Out

  • Brady Basso
    RP

    Basso is out with shoulder

    Out

See more MLB Injuries Right Arrow
Guardians vs. Athletics Box Score
Guardians Player Stats
Projected
PITCHERPCIPKER
Luis L. Ortiz logoRL.Ortiz, P926100
Cade Smith logoRC.Smith, P23121
Hunter Gaddis logoRH.Gaddis, P9111
Emmanuel Clase logoRE.Clase, P12100
HITTERSH-ABRHRRBI
Steven Kwan logo1S.Kwan, LF3-5101
Kyle Manzardo logo2K.Manzardo, DH2-5000
Jose Ramirez logo3J.Ramirez, 3B3-4001
Carlos Santana logo4C.Santana, 1B0-5000
Daniel Schneemann logo5D.Schneemann, SS0-5000
Nolan Jones logo6N.Jones, CF0-2100
Lane Thomas logo6L.Thomas, PH0-0000
Lane Thomas logo6L.Thomas, CF0-0000
Bo Naylor logo7B.Naylor, C1-3101
David Fry logo7D.Fry, PH0-1000
Austin Hedges logo7A.Hedges, C0-0000
Johnathan Rodriguez logo8J.Rodriguez, RF1-4101
Angel Martinez logo9A.Martinez, 2B0-4000
Athletics Player Stats
Projected
PITCHERPCIPKER
Mitch Spence logoRM.Spence, P854.234
T.J. McFarland logoLT.McFarland, P50.110
Sean Newcomb logoLS.Newcomb, P34220
Hogan Harris logoLH.Harris, P38240
HITTERSH-ABRHRRBI
Lawrence Butler logo1L.Butler, RF0-3000
Denzel Clarke logo1D.Clarke, CF0-1000
Jacob Wilson logo2J.Wilson, SS0-4000
Brent Rooker logo3B.Rooker, LF1-3100
Brent Rooker logo3B.Rooker, RF1-3100
Nick Kurtz logo4N.Kurtz, DH0-3000
Max Muncy logo5M.Muncy, 3B0-3001
Tyler Soderstrom logo6T.Soderstrom, 1B1-4000
JJ Bleday logo7J.Bleday, CF0-3100
JJ Bleday logo7J.Bleday, LF0-3100
Luis Urias logo8L.Urias, 2B2-4000
Austin Wynns logo9A.Wynns, C1-4001

Guardians vs. Athletics Odds Comparison

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Guardians at Athletics Team Totals

MatchupOverUnder
Guardians
67-66
o4.5-132
u4.5+103
Athletics
63-73
o4.5+110
u4.5-141