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Astros vs. Angels Odds & Betting Predictions - June 22, 2025

Astros at Angels

1:38 am • FDSW

Houston Astros

60-44
1
1 - 9

Los Angeles Angels

50-54
9
Starting Pitchers
pitcherteameraw-l
Jose Soriano logoJ.SorianoLos Angeles Angels logo3.797-7
Brandon Walter logoB.WalterHouston Astros logo3.351-3

Astros at Angels Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Astros
60-44
-1.5
+1.5-194
o8.5-108
+108
Angels
50-54
u8.5
-1.5+168
u8.5-114
-130
location pinSunday 1:38 a.m.
June 22, 2025
Angel StadiumAnaheim
Astros vs. Angels Expert Picks
Al’s Analytics
Al’s Analytics
13d ago
Last 30d: 48-44-0 (+2.5u)
LAA -110
0.91u
Allan Lem
Allan Lem
35d ago
Last 30d: 55-43-2 (+1.2u)
Under 4.5 (F5)-138
0.5u
Tailing @cawright95
Charlie Wright
Charlie Wright
35d ago
Last 30d: 7-3-0 (+2.4u)
B.Walter o4.5 Ks-110
1u
Grabbing this too. Love what we’ve seen from Walter.
Under 4.5 (F5)-138
1.38u
Full writeup: https://www.actionnetwork.com/mlb/houston-astros-vs-los-angeles-angels-prediction-pick-odds-saturday-june-21-qs?utm_source=action_app&utm_medium=app&utm_campaign=article_share
Kyle Murray
Kyle Murray
35d ago
Last 30d: 55-101-4 (-15.8u)
B.Walter o4.5 Ks-118
1u
Sean Zerillo
Sean Zerillo
35d ago
Last 30d: 157-159-11 (+9.4u)
HOU +110
0.5u
Bet to +100
Invisible Insider
Invisible Insider
35d ago
Last 30d: 14-7-0 (+3.5u)
LAA -125
0.8u
Picks Office
Picks Office
35d ago
Last 30d: 79-74-0 (+8.5u)
LAA -110
0.91u
Follow @PicksOffice on X to read the full writeup.
Capper Central
Capper Central
35d ago
Last 30d: 111-89-0 (+6.8u)
Under 8.5-117
1.17u
Boomer Betz
Boomer Betz
35d ago
Last 30d: 241-245-4 (+6.2u)
B.Walter u17.5 Outs+100
1u
Sandy Plashkes
Sandy Plashkes
35d ago
Last 30d: 82-71-2 (+18.8u)
Under 4 (F5)-110
1.1u
Boomer Betz
Boomer Betz
35d ago
Last 30d: 241-245-4 (+6.2u)
B.Walter u4.5 Ks+115
1u
Moneyline Hacks
Moneyline Hacks
36d ago
Last 30d: 75-78-8 (+43.1u)
LAA +101
1.01u
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Astros vs. Angels Previews & Analysis

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Prop Odds Comparison

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Line Movement Tracker

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Astros vs. Angels Public Betting Percentages

Away Logo

Astros

Public

Home Logo

Angels

62%

Bets%

38%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Angels are 1-4 in their last 5 games.
  • Angels are 2-3 in their last 5 games against the spread
  • Angels are 29-26 in their road games against the spread
  • The totals have gone OVER in 1 of Angels' last 5 games
  • The totals have gone OVER in 26 of Angels' 49 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Angels		57-4728-2129-268-1748-30
Astros		54-5026-2828-2230-4224-7

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Angels		54-47-326-21-228-26-113-11-141-35-2
Astros		44-55-523-3121-24-534-37-19-18-4

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Angels		50-5425-2425-3013-1236-42
Astros		60-4433-2127-2341-3119-12

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jun 21stHOUL 2-3+1.5 WU 8HOU +141
Jun 19th@NYYL 3-7+1.5 LU 10.5NYY +230
Jun 18th@NYYW 3-2+1.5 WU 9.5LAA +207
Jun 17th@NYYW 4-0+1.5 WU 9LAA +198
Jun 16th@NYYW 1-0+1.5 WU 8LAA +165

Angels vs. Astros Injury Updates

Angels Injuries

  • Anthony Rendon
    3B

    Rendon is out with hip

    Out

Astros Injuries

  • Jake Meyers
    CF

    Meyers is out with calf

    Out

  • Cristian Javier
    SP

    Javier is out with elbow

    Out

  • Jeremy Pena
    SS

    Pena is out with ribs

    Out

  • Luis Garcia
    SP

    Garcia is out with elbow

    Out

  • Pedro Leon
    RF

    Leon is out with knee

    Out

  • J.P. France
    SP

    France is out with shoulder

    Out

  • Hayden Wesneski
    RP

    Wesneski is out with elbow

    Out

  • Spencer Arrighetti
    SP

    Arrighetti is out with thumb

    Out

See more MLB Injuries Right Arrow
Astros vs. Angels Box Score
Astros Player Stats
Projected
PITCHERPCIPKER
Brandon Walter logoLB.Walter, P99667
Kaleb Ort logoRK.Ort, P26122
Nick Hernandez logoRN.Hernandez, P23110
HITTERSH-ABRHRRBI
Jeremy Pena logo1J.Pena, SS0-3000
Cooper Hummel logo1C.Hummel, PH0-0000
Cooper Hummel logo1C.Hummel, LF0-0000
Isaac Paredes logo2I.Paredes, 3B1-3000
Mauricio Dubon logo2M.Dubon, PH0-1000
Mauricio Dubon logo2M.Dubon, SS0-1000
Jose Altuve logo3J.Altuve, LF0-0100
Shay Whitcomb logo3S.Whitcomb, PH0-1000
Shay Whitcomb logo3S.Whitcomb, 2B0-1000
Yainer Diaz logo4Y.Diaz, C0-4000
Cesar Salazar logo4C.Salazar, C0-0000
Cam Smith logo5C.Smith, RF0-4000
Christian Walker logo6C.Walker, 1B1-4001
Victor Caratini logo7V.Caratini, DH0-4000
Jake Meyers logo8J.Meyers, CF1-3000
Luis Guillorme logo9L.Guillorme, 2B0-3000
Luis Guillorme logo9L.Guillorme, 3B0-3000
Angels Player Stats
Projected
PITCHERPCIPKER
Jose Soriano logoRJ.Soriano, P966.2101
Hector Neris logoRH.Neris, P40.110
Sam Bachman logoRS.Bachman, P22220
HITTERSH-ABRHRRBI
Zach Neto logo1Z.Neto, SS2-4100
Kevin Newman logo1K.Newman, SS1-1000
Nolan Schanuel logo2N.Schanuel, 1B2-3101
LaMonte Wade logo2L.Wade, 1B0-1000
Mike Trout logo3M.Trout, DH1-4100
Taylor Ward logo4T.Ward, LF1-4202
Logan O'Hoppe logo5L.O'Hoppe, C2-4224
Jo Adell logo6J.Adell, CF1-3100
Luis Rengifo logo7L.Rengifo, 3B1-4112
Gustavo Campero logo8G.Campero, RF0-4000
Christian Moore logo9C.Moore, 2B0-4000

Astros vs. Angels Odds Comparison

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Astros at Angels Team Totals

MatchupOverUnder
Astros
60-44
o3.5-135
u3.5+105
Angels
50-54
o4-113
u4-113