Pirates vs. Cardinals Odds & Betting Predictions - May 21, 2026
Pirates at Cardinals
5:15 pm • CARDStarting Pitchers
| pitcher | team | era | w-l | |
|---|---|---|---|---|
 |  | 4.81 | 3-4 | |
 |  | 3.09 | 2-2 |
Pirates at Cardinals Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Pirates 25-24 | -1.5 | -1.5+133 | o7.5-106 | -132 |
Cardinals 28-20 | u7.5 | +1.5-160 | u7.5-113 | +110 |
Busch StadiumSt. Louis
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Pirates vs. Cardinals Expert Picks
RoyalsProps
Last 30d: 76-46-5 (+26.2u)
B.Lowe o1.5 Hits + Runs + RBIs+100
1u
Markus Markets
Last 30d: 51-39-0 (+5.4u)
D.May u17.5 Outs+120
0.83u
Anders
Last 30d: 11-12-0 (-0.7u)
Under 8-115
1.15u
+15.64U L10 Days🔥📈
Sean Zerillo
Last 30d: 172-146-12 (+4.5u)
Under 8-115
0.58u
Bet to 7.5 (-112)
Doug Ziefel
Last 30d: 186-147-2 (+17.0u)
Over 7.5-112
0.56u
Pirates vs. Cardinals Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Pirates vs. Cardinals Public Betting Percentages
Betting Trends
- Cardinals are 3-2 in their last 5 games.
- Cardinals are 3-2 in their last 5 games against the spread
- Cardinals are 15-8 in their road games against the spread
- The totals have gone OVER in 2 of Cardinals' last 5 games
- The totals have gone OVER in 12 of Cardinals' 25 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Pirates vs. Cardinals Injury Updates
Pirates Injuries
- Jared JonesSP
Jones is out with elbow
Out
Cardinals Injuries
- Lars NootbaarLF
Nootbaar is out with heel
Out
Pirates vs. Cardinals Starting Lineups
Pirates Starting Lineup| PITCHER | W-L | ERA | WHIP | K/9 | |
|---|---|---|---|---|---|
 | 2-2 | 3.09 | 1.048 | 9.11 |
| HITTERS | AVG | OBP | SLG | HR |
|---|---|---|---|---|
 | .319 | .379 | .363 | 0 |
 | .250 | .342 | .542 | 12 |
 | .251 | .380 | .389 | 4 |
 | .259 | .327 | .457 | 10 |
 | .179 | .275 | .305 | 5 |
 | .276 | .381 | .433 | 4 |
 | .278 | .333 | .405 | 3 |
 | .259 | .333 | .284 | 0 |
 | .137 | .241 | .232 | 2 |
Cardinals Starting Lineup| PITCHER | W-L | ERA | WHIP | K/9 | |
|---|---|---|---|---|---|
 | 3-4 | 4.81 | 1.418 | 6.47 |
| HITTERS | AVG | OBP | SLG | HR |
|---|---|---|---|---|
 | .244 | .364 | .422 | 9 |
 | .257 | .384 | .408 | 5 |
 | .286 | .356 | .462 | 7 |
 | .296 | .368 | .570 | 13 |
 | .234 | .320 | .377 | 6 |
 | .248 | .324 | .344 | 1 |
 | .247 | .282 | .390 | 5 |
 | .208 | .257 | .356 | 4 |
 | .190 | .246 | .267 | 2 |
Pirates vs. Cardinals Odds Comparison
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Pirates at Cardinals Team Totals
MatchupOverUnder | ||
|---|---|---|
Pirates 25-24 | N/A | N/A |
Cardinals 28-20 | N/A | N/A |