Cubs vs. Padres Odds & Betting Predictions - April 28, 2026

Cubs at Padres

1:40 am • MARQ
@
Starting Pitchers
pitcherteameraw-l
Randy Vasquez logoR.VasquezSan Diego Padres logo1.882-0
Matthew Boyd logoM.BoydChicago Cubs logo5.791-1

Cubs at Padres Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Cubs
17-11
-1.5
-1.5+165
o7.5-115
-105
Padres
18-9
u8
+1.5-185
u7.5-105
-115
location pinTuesday 1:40 a.m.
April 28, 2026
Petco ParkSan Diego
thermometer image63°Fahrenheit
rain image0%Rain
wind image9Wind
Cubs vs. Padres Expert Picks
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 293-298-11 (+16.8u)
N.Hoerner o1.5 Total Bases+140
0.46u
#EV 5.16% Pinny +109 BO +117
Payoff Pitch Podcast
Payoff Pitch Podcast
Last 30d: 89-121-8 (+13.1u)
Under 8-110
0.5u
@Zerillo ⭐️⭐️ https://myaction.app/pHsh0nYiG2b
M.Machado o1.5 Total Bases+145
0.5u
@cowhitchurch ⭐️⭐️ https://myaction.app/pHsh0nYiG2b
I.Happ o1.5 Total Bases+165
0.5u
@cowhitchurch ⭐️⭐️ https://myaction.app/pHsh0nYiG2b
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 293-298-11 (+16.8u)
M.Boyd o5.5 Ks+145
0.38u
#EV 4.4% FD +118 BO +117
Under 4 (F5)+115
0.58u
#EV 2.67% Pinny +103 Circa +100 BO +100
RoyalsProps
RoyalsProps
Last 30d: 66-57-7 (+4.4u)
S.Suzuki o1.5 Hits + Runs + RBIs-106
1.06u
Frank Ammirante
Frank Ammirante
Last 30d: 314-340-14 (+5.1u)
M.Boyd o15.5 Outs-124
1.24u
SD u3.5-105
1.05u
CHC -110
1.1u
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 293-298-11 (+16.8u)
Over 0.5 (1st Inn)+115
0.67u
#EV 6.19% Pinny -105 FD -113
Sean Zerillo
Sean Zerillo
Last 30d: 169-158-13 (-6.0u)
Under 8-105
0.53u
Bet to -115
Matt Trollo
Matt Trollo
Last 30d: 49-52-6 (-4.5u)
Under 8-105
1.05u
(DK) 94 PRF, cool temps, forecast historically more suppressive by 7-8% - see notes on F5 – two strong defenses (CHC best) – SDP best bullpen estimators MLB (Would decrease to 0.5u at 7.5)
CHC -128 (F5)
0.64u
(FD) Vasquez has been impressive (19.3 K-BB%), but still 13.5% Barrels/BBE (4.33 xERA), Boyd 2.02 SIERA/3.74 xERA through 3 starts – CHC proj LU 21 pt wRC+ edge v L/RHP since LY, teams separated by 35 points this year – CHC 11 Runs Prevented, proj LU 15 FRV best in MLB – SDP far better pen though, so F5 (Would only play to -135)
Doug Ziefel
Doug Ziefel
Last 30d: 269-337-21 (-20.0u)
SD +100
0.5u

Prop Odds Comparison

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Line Movement Tracker

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Cubs vs. Padres Public Betting Percentages

Away Logo

Cubs

Public

41%

Bets%

59%

Money%

MLB Public Betting Right Arrow

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Padres
17-1010-37-710-57-5
Cubs
14-149-75-78-96-5

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Padres
11-15-16-6-15-96-8-15-7
Cubs
17-119-78-49-88-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Padres
18-99-49-511-47-5
Cubs
17-1111-56-611-66-5

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Apr 26th@ARIL 7-12-1.5 LO 14.5ARI -135
Apr 25th@ARIW 6-4-U 16SD -106
Apr 23rd@COLW 10-8-1.5 WO 10.5SD -155
Apr 23rd@COLL 3-8-1.5 LU 12COL -161
Apr 22nd@COLW 1-0-1.5 LU 11SD -147

Cubs vs. Padres Injury Updates

Cubs Injuries

  • Tyler Austin
    1B

    Austin is out with knee

    Out

  • Justin Steele
    SP

    Steele is out with elbow

    Out

  • Yacksel Rios
    RP

    Rios is out with shoulder

    Out

  • Jordan Wicks
    SP

    Wicks is out with arm

    Out

Padres Injuries

  • Joe Musgrove
    SP

    Musgrove is out with elbow

    Out

  • Griffin Canning
    SP

    Canning is out with achilles

    Out

  • Will Wagner
    3B

    Wagner is out with oblique

    Out

Cubs vs. Padres Starting Lineups
Cubs Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Matthew Boyd logoLM.Boyd, P1-15.791.14314.14
HITTERSAVGOBPSLGHR
Nico Hoerner logo1N.Hoerner, 2B.307.382.4744
Michael Busch logo2M.Busch, 1B.214.299.3112
Alex Bregman logo3A.Bregman, 3B.252.336.3743
Ian Happ logo4I.Happ, LF.235.350.4807
Seiya Suzuki logo5S.Suzuki, RF.305.414.5254
Moises Ballesteros logo6M.Ballesteros, DH.397.446.6904
Dansby Swanson logo7D.Swanson, SS.191.325.4156
Pete Crow-Armstrong logo8P.Crow-Armstrong, CF.238.298.3141
Miguel Amaya logo9M.Amaya, C.234.345.3832
Padres Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Randy Vasquez logoRR.Vasquez, P2-01.881.0819.42
HITTERSAVGOBPSLGHR
Ramon Laureano logo1R.Laureano, LF.255.318.4594
Fernando Tatis logo2F.Tatis, RF.250.333.2900
Jackson Merrill logo3J.Merrill, CF.214.283.3593
Manny Machado logo4M.Machado, 3B.209.327.3634
Xander Bogaerts logo5X.Bogaerts, SS.278.358.4234
Miguel Andujar logo6M.Andujar, DH.311.344.4430
Ty France logo7T.France, 1B.265.306.5593
Freddy Fermin logo8F.Fermin, C.186.315.2560
Jake Cronenworth logo9J.Cronenworth, 2B.155.283.2141

Cubs vs. Padres Odds Comparison

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Cubs at Padres Team Totals

MatchupOverUnder
Cubs
17-11
N/A
N/A
Padres
18-9
N/A
N/A