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Chargers vs. 49ers Odds & Betting Predictions - August 24, 2025

Chargers at 49ers

12:30 am • NFL+

Los Angeles Chargers

0-0
23
23 - 30

San Francisco 49ers

0-0
30

Chargers at 49ers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Chargers
0-0
+3
-2.5-116
o35.5-118
-152
49ers
0-0
u37.5
+2.5-103
u35.5-105
+125
location pinSunday 12:30 a.m.
August 24, 2025
Levi's StadiumSanta Clara
Chargers vs. 49ers Expert Picks
Wags Wins
Wags Wins
Last 30d: 176-162-0 (-4.1u)
Under 36.5-115
1.25u
JC Cornell
JC Cornell
Last 30d: 45-52-0 (-38.3u)
LAC -1.5-107
3u
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 106-111-5 (-11.1u)
Under 37.5-105
0.53u
🔗 https://whop.com/checkout/plan_EmUfhfnU87m47/?a=userd0a02663735&d2c=true

Chargers vs. 49ers Previews & Analysis

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Chargers vs. 49ers Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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Chargers vs. 49ers Public Betting Percentages

Away Logo

Chargers

Public

Home Logo

49ers

69%

Bets%

31%

Money%

NFL Public Betting Right Arrow

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
49ers		N/AN/AN/AN/AN/A
Chargers		N/AN/AN/AN/AN/A

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
49ers		N/AN/AN/AN/AN/A
Chargers		N/AN/AN/AN/AN/A

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
49ers		N/AN/AN/AN/AN/A
Chargers		N/AN/AN/AN/AN/A

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Aug 16th@LVW 22-19+4.5 WO 40.5SF +180
Aug 10thDENL 9-30+6.5 LO 38.5DEN +240
Jan 5th@ARIL 24-47+5.5 LO 43.5ARI +195
Dec 31stDETL 34-40+4 LO 50.5DET +182
Dec 22nd@MIAL 17-29-1.5 LO 44MIA -125

49ers vs. Chargers Injury Updates

49ers Injuries

  • Demarcus Robinson
    WR

    Robinson is out with suspension

    Out

  • Brandon Aiyuk
    WR

    Aiyuk is out with knee

    Out

  • Trevis Gipson
    LB

    Gipson is out with ankle

    Out

  • Jauan Jennings
    WR

    Jennings is questionable with calf

    Questionable

  • Jacob Cowing
    WR

    Cowing is out with hamstring

    Out

Chargers Injuries

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    Team Stats

    Total

    321
    Total Yards
    238
    68
    Total Plays
    62
    4.7
    Yards Per Play
    3.8

    Passing

    239
    YDS
    174
    24/44
    Comps/Atts
    18/27
    5.432
    YPA
    5.345
    2/1
    TDs/INTs
    2/0
    0/0
    Sacks/Yards
    2/19

    Rushing

    82
    Rush Yards
    83
    24
    Attempts
    33
    3.417
    YPC
    2.515
    0
    TDs
    1

    Turnovers

    3
    Fumbles Lost
    2
    1
    Interceptions
    0

    Efficiency

    1/3 33.33%
    Redzone
    2/2 100%
    3/13 0%
    3rd Down
    3/13 0%
    1/1 0%
    4th Down
    0/1 0%

    First Downs

    21
    Total
    15
    11
    Pass
    9
    6
    Rush
    5
    4
    Penalty
    1

    Misc

    11/74
    Penalties/Yards
    12/67
    30:03
    Possession
    29:57

    Chargers vs. 49ers Odds Comparison

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    Chargers at 49ers Team Totals

    MatchupOverUnder
    Chargers
    0-0
    o19.5-105
    u19.5-120
    49ers
    0-0
    o16.5-110
    u16.5-115