Chargers vs. 49ers Odds & Betting Predictions - August 24, 2025

Chargers at 49ers

12:30 am • NFL+

Los Angeles Chargers

23

23 - 30

San Francisco 49ers

30

MatchupOpenSpreadTotalMoneyline
Chargers 3-1	+3	-2.5-116	o35.5-118	-152
49ers 3-1	u37.5	+2.5-103	u35.5-105	+125

location pin

Sunday 12:30 a.m.

August 24, 2025

Levi's StadiumSanta Clara

Under 36.5-115

1.25u

LAC -1.5-107

3u

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NFL Public Betting

49ers are 3-1 in their last 5 games.
49ers are 2-2 in their last 5 games against the spread
49ers are 2-0 in their road games against the spread
The totals have gone OVER in 2 of 49ers' last 4 games
The totals have gone OVER in 1 of 49ers' 2 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
49ers	2-2	0-2	2-0	2-2	N/A
Chargers	3-1	1-0	1-1	2-1	1-0

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
49ers	2-2	1-1	1-1	2-2	N/A
Chargers	1-3	0-1	0-2	0-3	1-0

Straight-Up (ML) History

	overall	home	away	favorite	underdog
49ers	3-1	N/A	N/A	3-1	N/A
Chargers	3-1	N/A	N/A	2-1	1-0

date	opponent	score	spread	over/under	moneyline
Aug 16th	@LV	W 22-19	+4.5 W	O 40.5	SF +180
Aug 10th	DEN	L 9-30	+6.5 L	O 38.5	DEN +240
Jan 5th	@ARI	L 24-47	+5.5 L	O 43.5	ARI +195
Dec 31st	DET	L 34-40	+4 L	O 50.5	DET +182
Dec 22nd	@MIA	L 17-29	-1.5 L	O 44	MIA -125

George Kittle
TE
Kittle is out with hamstring
Out
Brandon Aiyuk
WR
Aiyuk is out with knee
Out
Jauan Jennings
WR
Jennings is out with ankle
Out
Brock Purdy
QB
Purdy is out with toe
Out
Ricky Pearsall
WR
Pearsall is out with knee
Out
Jacob Cowing
WR
Cowing is out with hamstring
Out

Jordan Watkins
WR
Watkins is doubtful with ankle
Doubtful
Jordan James
RB
James is doubtful with finger
Doubtful

Will Dissly
TE
Dissly is out with knee
Out
Najee Harris
RB
Harris is out with achilles
Out

See more NFL Injuries

Total

321

Total Yards

238

68

Total Plays

62

4.7

Yards Per Play

3.8

Passing

239

YDS

174

24/44

Comps/Atts

18/27

5.432

YPA

5.345

2/1

TDs/INTs

2/0

0/0

Sacks/Yards

2/19

Rushing

82

Rush Yards

83

24

Attempts

33

3.417

YPC

2.515

0

TDs

1

Turnovers

3

Fumbles Lost

2

1

Interceptions

0

Efficiency

1/3 33.33%

Redzone

2/2 100%

3/13 0%

3rd Down

3/13 0%

1/1 0%

4th Down

0/1 0%

First Downs

21

Total

15

11

Pass

9

6

Rush

5

4

Penalty

1

Misc

11/74

Penalties/Yards

12/67

30:03

Possession

29:57

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MatchupOverUnder
Chargers 3-1	o19.5-105	u19.5-120
49ers 3-1	o16.5-110	u16.5-115