Chargers vs. 49ers Odds & Betting Predictions - August 24, 2025

Chargers at 49ers

12:30 am • NFL+

Los Angeles Chargers

11-5

23 - 30

San Francisco 49ers

12-4

MatchupOpenSpreadTotalMoneyline
Chargers 11-5	-2.5-116	o35.5-118	-152
49ers 12-4	+2.5-103	u35.5-105	+125

Sunday 12:30 a.m.

August 24, 2025

Levi's StadiumSanta Clara

Under 36.5-115

1.25u

LAC -1.5-107

Under 37.5-105

0.53u

🔗 https://whop.com/checkout/plan_EmUfhfnU87m47/?a=userd0a02663735&d2c=true

A Pros-vs.-Joes Saturday Night Special!
Alex Kolodziej•
Aug 24, 2025 UTC
Chargers vs. 49ers: First-Half Moneyline Prediction
Dead President Picks•
Aug 23, 2025 UTC
Saturday's O/U Landing Market-Moving Action
Alex Kolodziej•
Aug 21, 2025 UTC

See more NFL Coverage

There are no prop projections found for the selected slate. Please check back later.

No props found

NFL Public Betting

49ers are 2-3 in their last 5 games.
49ers are 2-3 in their last 5 games against the spread
49ers are 7-2 in their road games against the spread
The totals have gone OVER in 3 of 49ers' last 5 games
The totals have gone OVER in 4 of 49ers' 7 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
49ers	10-6	3-4	7-2	8-3	2-3
Chargers	9-7	5-3	3-4	5-7	4-0

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
49ers	10-6	4-3	6-3	7-4	3-2
Chargers	7-9	3-5	3-4	5-7	2-2

Straight-Up (ML) History

	overall	home	away	favorite	underdog
49ers	12-4	N/A	N/A	10-1	2-3
Chargers	11-5	N/A	N/A	7-5	4-0

date	opponent	score	spread	over/under	moneyline
Aug 16th	@LV	W 22-19	+4.5 W	O 40.5	SF +180
Aug 10th	DEN	L 9-30	+6.5 L	O 38.5	DEN +240
Jan 5th	@ARI	L 24-47	+5.5 L	O 43.5	ARI +195
Dec 31st	DET	L 34-40	+4 L	O 50.5	DET +182
Dec 22nd	@MIA	L 17-29	-1.5 L	O 44	MIA -125

George Kittle
TE
Kittle is questionable with ankle
Questionable

Brandon Aiyuk
WR
Aiyuk is out with knee
Out
Jacob Cowing
WR
Cowing is out with hamstring
Out

Keenan Allen
WR
Allen is doubtful with rest
Doubtful
Justin Herbert
QB
Herbert is out with rest
Out
Najee Harris
RB
Harris is out with achilles
Out
Hassan Haskins
RB
Haskins is questionable with head
Questionable
Quentin Johnston
WR
Johnston is doubtful with rest
Doubtful
Derius Davis
WR
Davis is questionable with ankle
Questionable
Ladd McConkey
WR
McConkey is doubtful with rest
Doubtful
Kimani Vidal
RB
Vidal is doubtful with rest
Doubtful
Omarion Hampton
RB
Hampton is doubtful with rest
Doubtful
Oronde Gadsden
TE
Gadsden is doubtful with rest
Doubtful

See more NFL Injuries

Chargers

Total

49ers

321

Total Yards

238

Total Plays

4.7

Yards Per Play

3.8

Chargers

Passing

49ers

239

YDS

174

24/44

Comps/Atts

18/27

5.432

YPA

5.345

2/1

TDs/INTs

2/0

0/0

Sacks/Yards

2/19

Chargers

Rushing

49ers

Rush Yards

Attempts

3.417

YPC

2.515

TDs

Chargers

Turnovers

49ers

Fumbles Lost

Interceptions

Chargers

Efficiency

49ers

1/3 33.33%

Redzone

2/2 100%

3/13 0%

3rd Down

3/13 0%

1/1 0%

4th Down

0/1 0%

Chargers

First Downs

49ers

Total

Pass

Rush

Penalty

Chargers

Misc

49ers

11/74

Penalties/Yards

12/67

30:03

Possession

29:57

Could not load odds

See more NFL Odds

MatchupOverUnder
Chargers 11-5	o19.5-105	u19.5-120
49ers 12-4	o16.5-110	u16.5-115

Chargers vs. 49ers Odds & Betting Predictions - August 24, 2025

Chargers at 49ers

Los Angeles Chargers

San Francisco 49ers

Chargers at 49ers Odds

Spread, Total, Moneyline

Chargers vs. 49ers Previews & Analysis

A Pros-vs.-Joes Saturday Night Special!

Chargers vs. 49ers: First-Half Moneyline Prediction

Saturday's O/U Landing Market-Moving Action

Chargers vs. 49ers Props

Prop Projections

Prop Odds Comparison

Line Movement Tracker

Chargers vs. 49ers Public Betting Percentages

Chargers

Public

49ers

Bets%

Money%

Betting Trends

Matchup History

Against the Spread (ATS) History

Over/Under History

Straight-Up (ML) History

Last 5 Matchups

49ers vs. Chargers Injury Updates

49ers Injuries

Chargers Injuries

Chargers vs. 49ers Odds Comparison

Chargers at 49ers Team Totals