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Broncos vs. 49ers Odds & Betting Predictions - August 10, 2025

Broncos at 49ers

12:30 am • NFL+

Denver Broncos

1-0
30
30 - 9

San Francisco 49ers

1-1
9

Broncos at 49ers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Broncos
1-0
-6.5-109
o38.5-109
-280
49ers
1-1
+6.5-111
u38.5-110
+240
location pinSunday 12:30 a.m.
August 10, 2025
Levi's StadiumSanta Clara

Broncos vs. 49ers Previews & Analysis

  • Top Saturday Trends, Smart Money Picks article feature image

    Top Saturday Trends, Smart Money Picks

    Alex Kolodziej•
    Aug 9, 2025 UTC
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Broncos vs. 49ers Props

Prop Projections

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Line Movement Tracker

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Broncos vs. 49ers Public Betting Percentages

Away Logo

Broncos

Public

Home Logo

49ers

40%

Bets%

60%

Money%

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Betting Trends

  • 49ers are 2-3 in their last 5 games.
  • 49ers are 2-3 in their last 5 games against the spread
  • 49ers are 7-2 in their road games against the spread
  • The totals have gone OVER in 3 of 49ers' last 5 games
  • The totals have gone OVER in 4 of 49ers' 8 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
49ers		10-73-57-28-32-4
Broncos		7-105-42-53-94-1

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
49ers		10-74-46-37-43-3
Broncos		7-104-53-46-61-4

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
49ers		12-5N/AN/A10-12-4
Broncos		14-3N/AN/A10-24-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jan 5th@ARIL 24-47+5.5 LO 43.5ARI +195
Dec 31stDETL 34-40+4 LO 50.5DET +182
Dec 22nd@MIAL 17-29-1.5 LO 44MIA -125
Dec 13thLAL 6-12-3 LU 48.5LA -155
Dec 8thCHIW 38-13-3 WO 43.5SF -163

49ers vs. Broncos Injury Updates

49ers Injuries

  • George Kittle
    TE

    Kittle is out with achilles

    Out

  • Brandon Aiyuk
    WR

    Aiyuk is out with knee

    Out

  • Colton Dowell
    WR

    Dowell is out with knee

    Out

  • Jacob Cowing
    WR

    Cowing is out with hamstring

    Out

Broncos Injuries

  • J.K. Dobbins
    RB

    Dobbins is questionable with foot

    Questionable

  • Bo Nix
    QB

    Nix is out with ankle

    Out

  • Troy Franklin
    WR

    Franklin is doubtful with hamstring

    Doubtful

  • Pat Bryant
    WR

    Bryant is doubtful with concussion

    Doubtful

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Team Stats

Total

368
Total Yards
203
72
Total Plays
53
5.1
Yards Per Play
3.8

Passing

222
YDS
127
26/36
Comps/Atts
13/27
5.658
YPA
3.567
3/0
TDs/INTs
0/3
2/7
Sacks/Yards
3/20

Rushing

153
Rush Yards
96
34
Attempts
23
4.5
YPC
4.174
0
TDs
1

Turnovers

0
Fumbles Lost
1
0
Interceptions
3

Efficiency

2/3 66.67%
Redzone
1/1 100%
6/16 0%
3rd Down
1/12 0%
1/2 0%
4th Down
1/2 0%

First Downs

20
Total
11
12
Pass
5
7
Rush
3
1
Penalty
3

Misc

11/87
Penalties/Yards
9/67
36:58
Possession
23:02

Broncos vs. 49ers Odds Comparison

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Broncos at 49ers Team Totals

MatchupOverUnder
Broncos
1-0
o22.5-115
u22.5-110
49ers
1-1
o15.5-120
u15.5-105