Syracuse vs. Notre Dame Odds & Betting Predictions - November 22, 2025

Syracuse at Notre Dame

8:30 pm • NBC

Syracuse Orange

@

Notre Dame Fighting Irish

MatchupOpenSpreadTotalMoneyline
Syracuse 3-7	+34.5	+35.5-110	o50.5-112	N/A
Notre Dame 8-2	u51.5	-35.5-110	u50.5-107	N/A

location pin

Saturday 8:30 p.m.

November 22, 2025

Notre Dame StadiumSouth Bend

thermometer image

48°Fahrenheit

rain image

0%Rain

wind image

3Wind

No props found

NCAAF Public Betting

Notre Dame are 4-1 in their last 5 games.
Notre Dame are 4-1 in their last 5 games against the spread
Notre Dame are 2-2 in their road games against the spread
The totals have gone OVER in 4 of Notre Dame' last 5 games
The totals have gone OVER in 3 of Notre Dame' 6 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Notre Dame	5-5	3-3	2-2	5-5	N/A
Syracuse	4-5-1	1-3-1	3-1	0-1-1	3-4

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Notre Dame	5-5	3-3	2-2	5-5	N/A
Syracuse	5-5	1-4	3-1	0-2	4-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Notre Dame	8-2	N/A	N/A	8-2	N/A
Syracuse	3-7	N/A	N/A	1-1	1-6

date	opponent	score	spread	over/under	moneyline
Nov 15th	@PITT	W 37-15	-13.5 W	U 55.5	ND -477
Nov 9th	NAVY	W 49-10	-30.5 W	O 54.5	ND -5836
Nov 1st	@BC	W 25-10	-31.5 L	U 55.5	ND -8000
Oct 18th	USC	W 34-24	-10.5 L	U 60.5	ND -370
Oct 11th	NCST	W 36-7	-23.5 W	U 59.5	ND -2400

Total

Passing

2447

YDS

2657

204/361

Comps/Atts

185/272

6.78

YPA

9.77

17/12

TDs/INTs

21/6

31/228

Sacks/Yards

11/91

Rushing

1172

Rush Yards

1925

346

Attempts

367

3.39

YPC

5.25

10

TDs

28

Turnovers

Fumbles Lost

12

Interceptions

6

Efficiency

28/36 77.8%

Redzone

35/47 74.5%

49/141 0%

3rd Down

50/110 0%

13/27 0%

4th Down

13/27 0%

First Downs

203

Total

231

107

Pass

118

80

Rush

91

16

Penalty

22

Misc

/

Penalties/Yards

/

Could not load odds

See more NCAAF Odds

MatchupOverUnder
Syracuse 3-7	N/A	N/A
Notre Dame 8-2	N/A	N/A