Duke vs. Syracuse Odds & Betting Predictions - September 27, 2025
Duke at Syracuse
4:00 pm • ACC NetworkDuke at Syracuse Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
---|---|---|---|---|
![]() Duke 4-2 | -3.5 | -4.5-110 | o55.5-110 | -185 |
![]() Syracuse 3-3 | u55.5 | +4.5-110 | u55.5-110 | +155 |

JMA Wireless DomeSyracuse
Duke vs. Syracuse Expert Picks

The Propfessor
Last 30d: 32-47-2 (+4.3u)
R.Collins o242.5 Pass Yds-115
1u

Jeremiah Rose
Last 30d: 36-36-0 (-1.9u)
SYR +4.5-114
0.4u

Collin Wilson
Last 30d: 80-62-1 (+3.4u)
Over 59-115
1.15u

Sir Lockselot
Last 30d: 31-56-0 (-10.2u)
SYR +160
3u
📚Player Profit
🔑 Syracuse ML +160 (Player Profit) 3u
Cuse is rolling rn, at home in a good home environment. 2 basketball schools playing some good football rn, i love Cuse here. Sharp money on them too, we love it.
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Ryan Sura
Last 30d: 93-91-0 (+3.4u)
DUKE -4-110
1u

Picks Office
Last 30d: 60-70-2 (-6.4u)
Over 60.5+100
1u

Brian Bitler
Last 30d: 70-65-1 (+5.6u)
DUKE -4-110
2.73u

Dan Gaspar
Last 30d: 21-23-6 (-3.9u)
D.Mensah o277.5 Pass Yds-115
1.15u

Mike Calabrese
Last 30d: 18-32-0 (-16.0u)
Under 60.5-110
1u
Manny Diaz is going to force Rickie Collins to win from the pocket. A lot of empty possessions are on deck for the 🍊

Babs .
Last 30d: 76-75-0 (+1.9u)
Over 58.5-113
1u

Duck
Last 30d: 75-55-0 (+7.4u)
DUKE -3.5-110
1u
Duke vs. Syracuse Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Duke vs. Syracuse Public Betting Percentages
Betting Trends
- Syracuse are 2-3 in their last 5 games.
- Syracuse are 3-2 in their last 5 games against the spread
- Syracuse are 2-0 in their road games against the spread
- The totals have gone OVER in 3 of Syracuse' last 5 games
- The totals have gone OVER in 1 of Syracuse' 3 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Team Stats
268
YDS
229
22/28
Comps/Atts
24/37
9.571428571428571
YPA
6.1891891891891895
2/0
TDs/INTs
0/1
2/23
Sacks/Yards
1/7
Duke vs. Syracuse Odds Comparison
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Duke at Syracuse Team Totals
MatchupOverUnder | ||
---|---|---|
![]() Duke 4-2 | o31.5-112 | u31.5-114 |
![]() Syracuse 3-3 | o27.5-115 | u27.5-115 |