Duke vs. Syracuse Odds & Betting Predictions - September 27, 2025
Duke at Syracuse
4:00 pm • ACC NetworkDuke at Syracuse Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
Duke 4-3 | -3.5 | -4.5-110 | o55.5-110 | -185 |
Syracuse 3-5 | u55.5 | +4.5-110 | u55.5-110 | +155 |

JMA Wireless DomeSyracuse
Duke vs. Syracuse Expert Picks
The Propfessor
Last 30d: 38-50-0 (+4.3u)
R.Collins o242.5 Pass Yds-115
1u
Jeremiah Rose
Last 30d: 26-26-0 (+0.1u)
SYR +4.5-114
0.4u
Collin Wilson
Last 30d: 84-65-1 (+15.9u)
Over 59-115
1.15u
Sir Lockselot
Last 30d: 30-61-0 (-18.9u)
SYR +160
3u
📚Player Profit
🔑 Syracuse ML +160 (Player Profit) 3u
Cuse is rolling rn, at home in a good home environment. 2 basketball schools playing some good football rn, i love Cuse here. Sharp money on them too, we love it.
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Ryan Sura
Last 30d: 89-101-1 (-8.7u)
DUKE -4-110
1u
Picks Office
Last 30d: 120-98-4 (+15.3u)
Over 60.5+100
1u
Brian Bitler
Last 30d: 70-76-2 (-27.4u)
DUKE -4-110
2.73u
Dan Gaspar
Last 30d: 39-41-2 (-7.1u)
D.Mensah o277.5 Pass Yds-115
1.15u
Mike Calabrese
Last 30d: 30-35-0 (-3.4u)
Under 60.5-110
1u
Manny Diaz is going to force Rickie Collins to win from the pocket. A lot of empty possessions are on deck for the 🍊
Babs .
Last 30d: 94-110-3 (-11.7u)
Over 58.5-113
1u
Duck
Last 30d: 61-64-4 (-6.4u)
DUKE -3.5-110
1u
Duke vs. Syracuse Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Duke vs. Syracuse Public Betting Percentages
Betting Trends
- Syracuse are 2-3 in their last 5 games.
- Syracuse are 3-2 in their last 5 games against the spread
- Syracuse are 2-1 in their road games against the spread
- The totals have gone OVER in 2 of Syracuse' last 5 games
- The totals have gone OVER in 1 of Syracuse' 4 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Team Stats
268
YDS
229
22/28
Comps/Atts
24/37
9.571428571428571
YPA
6.1891891891891895
2/0
TDs/INTs
0/1
2/23
Sacks/Yards
1/7
Duke vs. Syracuse Odds Comparison
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Duke at Syracuse Team Totals
MatchupOverUnder | ||
|---|---|---|
Duke 4-3 | o31.5-112 | u31.5-114 |
Syracuse 3-5 | o27.5-115 | u27.5-115 |






