Syracuse vs. Clemson Odds & Betting Predictions - September 20, 2025

Syracuse at Clemson

4:00 pm • ESPN
34 - 21

Syracuse at Clemson Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Syracuse
3-3
+16.5
+17.5-108
o53.5-112
+600
Clemson
2-3
u55.5
-17.5-112
u53.5-110
-900
location pinSaturday 4:00 p.m.
September 20, 2025
Memorial Stadium (Clemson, SC)Clemson
Syracuse vs. Clemson Expert Picks
Collin Wilson
Collin Wilson
Last 30d: 101-72-4 (+14.0u)
CLEM +7.5 (Live)-115
1.15u
Capper Central
Capper Central
Last 30d: 90-60-1 (+15.5u)
CLEM -16.5-118
2.36u
Wags Wins
Wags Wins
Last 30d: 186-176-1 (-5.8u)
CLEM -16.5-118
1.25u
Brian Bitler
Brian Bitler
Last 30d: 74-79-1 (-24.3u)
CLEM -17-110
3u
Jeremiah Rose
Jeremiah Rose
Last 30d: 46-39-1 (+0.3u)
CLEM -16.5-115
0.25u
Boyd / FanDuel
💰🦡 Jake
💰🦡 Jake
Last 30d: 100-133-4 (+19.4u)
CLEM -9.5 (1H)-115
1.15u
Dan Gaspar
Dan Gaspar
Last 30d: 25-29-7 (-6.7u)
T.Moore o3.5 Recs+120
1.2u
Boomer Betz
Boomer Betz
Last 30d: 135-118-2 (+22.2u)
CLEM -17+100
1u

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Prop Odds Comparison

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Line Movement Tracker

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Syracuse vs. Clemson Public Betting Percentages

Away Logo

Syracuse

Public

62%

Bets%

38%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Clemson
1-40-31-11-4N/A
Syracuse
3-2-11-1-12-00-0-12-2

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Clemson
2-31-21-12-3N/A
Syracuse
3-31-21-10-12-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Clemson
2-3N/AN/A2-3N/A
Syracuse
3-3N/AN/A1-01-3

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 13th@GTL 21-24-3 LU 50.5GT -145
Sep 6thTROYW 27-16-30.5 LU 51.5CLEM -11946
Aug 30thLSUL 10-17-5 LU 55.5LSU -205
Dec 21st@TEXL 24-38+13.5 LO 49.5TEX +470
Dec 8th@SMUW 34-31+2.5 WO 56.5CLEM +111
Team Stats
433
Total Yards
503
77
Total Plays
83
5.623376623376624
Yards Per Play
6.0602409638554215
278
YDS
363
21/39
Comps/Atts
37/61
7.128205128205129
YPA
5.950819672131147
3/0
TDs/INTs
3/1
3/11
Sacks/Yards
1/1
155
Rush Yards
140
38
Attempts
22
4.078947368421052
YPC
6.363636363636363
1
TDs
0
0
Fumbles Lost
1
0
Interceptions
1

Efficiency

4/4 100%
Redzone
2/2 100%
3/15 0%
3rd Down
3/13 0%
2/2 0%
4th Down
1/5 0%

First Downs

24
Total
29
13
Pass
19
8
Rush
7
3
Penalty
3
7/52
Penalties/Yards
8/75

Syracuse vs. Clemson Odds Comparison

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Syracuse at Clemson Team Totals

MatchupOverUnder
Syracuse
3-3
o17.5-103
u17.5-127
Clemson
2-3
o35.5-114
u35.5-114