Tigers vs. Guardians Odds & Betting Predictions - September 23, 2025

Tigers at Guardians

10:40 pm • CLEG

Detroit Tigers

4-4

2 - 5

Cleveland Guardians

1-2

pitcher		team	era	w-l
G.Williams			3.06	12-5
T.Skubal			2.21	13-6

MatchupOpenSpreadTotalMoneyline
Tigers 4-4	-1.5	-1.5+114	o6.5-120	-164
Guardians 1-2	u6.5	+1.5-139	u6.5+100	+136

Tuesday 10:40 p.m.

September 23, 2025

Progressive FieldCleveland

Under 6.5-102

1.02u

Under 6.5-105

1.05u

Under 3.5 (F5)-125

This is an absolutely massive series and it should be treated like a playoff game. We’ll see quick hooks for the pitchers if they get into trouble early, which bodes well for the under. Tarik Skubal seemed to be good to go after an injury scare, cruising through 6 innings of 1-run ball against Cleveland in his last start. The Guardians rank bottom 5 in OPS, wOBA, and wRC+ vs. LHP since the start of August. Gavin Williams tossed 5 scoreless innings against Detroit in his last start. He’s allowed a total of 4 ERs in his last 4 outings. Williams draws a Tigers’ lineup that ranks 25th or worse in OPS, wOBA, and wRC+ vs. RHP over the past 30 days.

Under 3.5 (F5)-125

CLE +1.5-144

0.69u

G.Williams o1.5 BB-175

0.57u

@cowhitchurch https://myaction.app/AW9nNvaRTWb

T.Skubal u1.5 Earned Runs-140

1.07u

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No props found

MLB Public Betting

Guardians are 3-2 in their last 5 games.
Guardians are 1-4 in their last 5 games against the spread
Guardians are 47-34 in their road games against the spread
The totals have gone OVER in 2 of Guardians' last 5 games
The totals have gone OVER in 37 of Guardians' 81 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Guardians	86-76	39-42	47-34	33-36	51-38
Tigers	73-89	41-40	32-49	49-64	24-23

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Guardians	69-87-6	37-41-3	32-46-3	34-34-1	34-50-5
Tigers	83-72-7	41-35-5	42-37-2	58-49-6	24-22-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Guardians	88-74	45-36	43-38	44-25	43-46
Tigers	87-75	46-35	41-40	64-49	23-24

date	opponent	score	spread	over/under	moneyline
Sep 21st	@MIN	L 2-6	-1.5 L	U 8.5	MIN -143
Sep 20th	@MIN	W 8-0	-1.5 W	U 8.5	CLE -108
Sep 20th	@MIN	W 6-0	-	-	-
Sep 20th	@MIN	W 6-2	-1.5 W	O 7.5	CLE -113
Sep 18th	@DET	W 3-1	+1.5 W	U 7	CLE +196

Ben Lively
SP
Lively is out with elbow
Out
John Means
SP
Means is out with elbow
Out

Alex Cobb
SP
Cobb is out with hip
Out
Jose Urquidy
SP
Urquidy is out with arm
Out
Reese Olson
SP
Olson is out with shoulder
Out
Ty Madden
SP
Madden is out with shoulder
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
LT.Skubal, P	95	6	8	1
RT.Kahnle, P	14	0.2	2	1
RK.Finnegan, P	16	0.1	0	1
LB.Hurter, P	7	0.2	0	0
RR.Montero, P	5	0.1	0	0

HITTERS	H-AB	R	HR	RBI
1P.Meadows, CF	0-4	0	0	0
2G.Torres, 2B	0-4	0	0	0
3K.Carpenter, DH	1-4	0	0	0
4S.Torkelson, 1B	0-3	0	0	0
5R.Greene, LF	2-4	1	1	1
6D.Dingler, C	0-3	0	0	0
7Z.McKinstry, 3B	1-4	1	0	0
7Z.McKinstry, SS	1-4	1	0	0
8W.Perez, RF	1-3	0	0	1
9T.Sweeney, SS	0-2	0	0	0
9A.Ibanez, PH	0-1	0	0	0
9A.Ibanez, 3B	0-1	0	0	0

PITCHER	PC	IP	K	ER
RG.Williams, P	91	6	12	2
LE.Sabrowski, P	10	1	2	0
RH.Gaddis, P	19	1	3	0
RC.Smith, P	9	1	2	0

HITTERS	H-AB	R	RBI
1S.Kwan, LF	2-4	2	0
2A.Martinez, CF	1-2	1	0
2D.Schneemann, PH	1-1	0	2
2D.Schneemann, RF	1-1	0	2
3J.Ramirez, 3B	1-3	1	1
4D.Fry, DH	0-3	0	0
4G.Valera, PH	0-1	0	0
4G.Valera, DH	0-1	0	0
5G.Arias, SS	0-3	0	1
6K.Manzardo, 1B	1-3	0	0
6P.Halpin, CF	1-1	0	0
7J.Noel, RF	0-3	0	0
7J.Noel, 1B	0-3	0	0
8B.Rocchio, 2B	0-3	0	0
9A.Hedges, C	0-2	1	0