Guardians vs. Twins Odds & Betting Predictions - September 20, 2025

Guardians at Twins

12:10 am • CLEG

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Cleveland Guardians

@

Minnesota Twins

pitcher		team	era	w-l
P.Lopez			2.64	5-4
P.Messick			1.84	3-0

MatchupOpenSpreadTotalMoneyline
Guardians 80-71	+1.5	-1.5+168	o8-101	-101
Twins 66-86	u8	+1.5-207	u8-115	-120

location pin

Saturday 12:10 a.m.

September 20, 2025

Target FieldMinneapolis

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69°Fahrenheit

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44%Rain

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6Wind

CLE +105

0.5u

Bet to -102

No props found

MLB Public Betting

Twins are 1-4 in their last 5 games.
Twins are 2-3 in their last 5 games against the spread
Twins are 37-38 in their road games against the spread
The totals have gone OVER in 3 of Twins' last 5 games
The totals have gone OVER in 38 of Twins' 77 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Twins	73-79	36-41	37-38	36-50	35-28
Guardians	80-71	37-38	43-33	31-31	48-38

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Twins	72-74-6	38-36-3	34-38-3	42-41-3	28-32-3
Guardians	65-80-6	34-38-3	31-42-3	31-30-1	33-48-5

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Twins	66-86	37-40	29-46	41-45	24-39
Guardians	80-71	41-34	39-37	40-22	40-46

date	opponent	score	spread	over/under	moneyline
Sep 17th	NYY	L 5-10	+1.5 L	O 9.5	NYY +134
Sep 16th	NYY	L 9-10	+1.5 W	O 9	NYY +144
Sep 15th	NYY	W 7-0	+1.5 W	U 9	MIN +163
Sep 14th	ARI	L 4-6	-1.5 L	O 9.5	ARI -125
Sep 13th	ARI	L 2-5	-1.5 L	U 8.5	ARI -135

Ben Lively
SP
Lively is out with elbow
Out
John Means
SP
Means is out with elbow
Out

Alan Roden
LF
Roden is out with thumb
Out

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PITCHER		W-L	ERA	WHIP	K/9
LP.Messick, P		3-0	1.84	1.329	6.75

HITTERS	AVG	OBP	SLG	HR
1S.Kwan, LF	.275	.335	.377	10
2D.Schneemann, CF	.214	.293	.363	11
3J.Ramirez, 3B	.281	.357	.498	28
4K.Manzardo, 1B	.241	.323	.470	26
5B.Naylor, C	.188	.279	.360	12
6G.Arias, SS	.224	.279	.370	11
7N.Jones, RF	.211	.296	.305	5
8C.Kayfus, DH	.219	.291	.429	4
9B.Rocchio, 2B	.227	.288	.325	4

PITCHER		W-L	ERA	WHIP	K/9
RP.Lopez, P		5-4	2.64	1.102	8.92

HITTERS	AVG	OBP	SLG	HR
1B.Buxton, CF	.270	.333	.551	31
2A.Martin, LF	.296	.393	.392	1
3L.Keaschall, 2B	.311	.393	.449	4
4R.Lewis, 3B	.237	.287	.389	12
5C.McCusker, RF	.143	.143	.143	0
6B.Lee, SS	.242	.292	.379	15
7J.Pereda, C	.400	.455	.550	0
8K.Clemens, 1B	.218	.289	.458	19
9M.Gasper, DH	.165	.267	.242	2

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MatchupOverUnder
Guardians 80-71	N/A	N/A
Twins 66-86	N/A	N/A